Transport Analysis of Copper in Boac River Marinduque, Philippines

In 1996, over 1.6 million cubic meters of mine tailings were released along Boac River, Marinduque, Philippines declaring it biologically dead.  Numerous studies found traces of heavy metals along this river, and bioaccumulation became a problem. Several heavy metals contaminating the river were reported to be ingestible by humans; one of which is Copper (Cu). With that, this study investigated Cu dispersion in the downstream area of Boac River.  This was first done by coordinating with the “Development of Health Index: Vulnerability to Extreme Environmental Events for Marinduque island.” (D-HIVE) project in collecting the water quality data, rainfall data, and digital elevation models (DEMs).  Using the Hydrologic Engineering Center’s River Analysis System (HEC-RAS) 6.2, the analyses were conducted by inputting the collected data.  The flood hazard maps showed minimal spread in high-elevation areas and distinct spread in low-lying areas.  The highest flood velocity was in the starting and middle points of the watershed, indicating these areas have the highest potential to lift Cu content and transport it into the downstream area and floodplain. The spatial variability maps showed that pH increases while Cu content decreases as water flows toward the downstream area. Overall, this study successfully determined the dispersion of Cu along Boac River

Transport Analysis of Copper in Boac River Marinduque, Philippines

In 1996, over 1.6 million cubic meters of mine tailings were released along Boac River, Marinduque, Philippines declaring it biologically dead.  Numerous studies found traces of heavy metals along this river, and bioaccumulation became a problem. Several heavy metals contaminating the river were reported to be ingestible by humans; one of which is Copper (Cu). With that, this study investigated Cu dispersion in the downstream area of Boac River.  This was first done by coordinating with the “Development of Health Index: Vulnerability to Extreme Environmental Events for Marinduque island.” (D-HIVE) project in collecting the water quality data, rainfall data, and digital elevation models (DEMs).  Using the Hydrologic Engineering Center’s River Analysis System (HEC-RAS) 6.2, the analyses were conducted by inputting the collected data.  The flood hazard maps showed minimal spread in high-elevation areas and distinct spread in low-lying areas.  The highest flood velocity was in the starting and middle points of the watershed, indicating these areas have the highest potential to lift Cu content and transport it into the downstream area and floodplain. The spatial variability maps showed that pH increases while Cu content decreases as water flows toward the downstream area. Overall, this study successfully determined the dispersion of Cu along Boac River

Ground-Based Measurements and Validation Protocols for Flex

The upcoming ESA Fluorescence Explorer (FLEX) mission will incorporate ground-based validations for fluorescence parameters and reflectance indices, drawing on an international network of sensors located at eddy covariance tower sites. A program has been initiated by the OPTIMISE program to develop methods and protocols for this network. A sensor system suite under evaluation by OPTIMISE includes the FLoX hyperspectral spectroradiometers. The NASA team at GSFC is participating in this experiment and we report first results from the 2017 summer measurements made above the canopy at the USDA/ARS Beltsville cornfield using the DFLoX and two other leaf-level measurement systems, the MONI-PAM and the FluoWat

The Ursinus Weekly, December 17, 1969

Special centennial issue: Ursinus College\u27s 100th Anniversary, 1869-1969 • Editorial: The first hundred years • Focus: Nora Shuler Helfferich, Ursinus College\u27s oldest living alumnus • Reprinted articles: Pa. Governor Martin salutes President McClure and college at ceremony commemorating seventy-fifth anniversary; Ursinus adopts a war time program; Ursinus recipient of new gateway; Apology for peace; Freshman coed evaluates customs, finds friendly spirit on U.C. campus; Customs are savored; Chaperon, Why? Who?; WSGA is frowning on dungarees, slacks for Ursinus campus wear; When Shriner shrieks Ursinus sheiks come dashing from each dorm; Freshman President snatched by Sophs; Ursinus offers special class • Freeland Hall: Don\u27t let it be forgot • Ursinus raises $2,350,000;$550,000 still needed • Search into history substantiates claim of second oldest graduate that Freeland was everything • Ursinus administrators analyze past, present, and future • 1969 season climaxes 76 years • Mangan wins little All-American mention • Bears\u27 football since 1893 • Ray Gurzynski pilots Bear Harriers to 45-4 mark, two championships • Fifty years of girls\u27 field hockey at UC: Bearites to Snell-belles and champs • Albert leads UC Harriers to MAC championship • Footmen end season with 6-win record • 1969 MAC grid statistics • Concise history of Ursinus College: 1869 - present • Ursinus College: One century old, before and afterhttps://digitalcommons.ursinus.edu/weekly/1153/thumbnail.jp

The mysterious story of self- control

A brochure originally designed for an event as part of the ESRC Social Science Festival.Are you interested in learning how you can train your brain to control your impulses and urges? Everyday life is full of temptations, and we need good self-control to resist them. But every now and then, our self-control fails and we can no longer suppress our urges; we take risks we shouldn’t take, or make impulsive decisions that we later regret. We will tell you the mysterious story of self-control. We study how the human mind controls behaviour, introduces people to the mechanisms involved in resisting temptations. In addition, we explore how self-control may be strengthened via novel training tasks.ESRC, ERC, BBSRC, Welcome Trust Seed Corn Fundin

A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome

BACKGROUNDWolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Although there is no treatment for Wolfram syndrome, preclinical studies in cell and rodent models suggest that therapeutic strategies targeting ER calcium homeostasis, including dantrolene sodium, may be beneficial.METHODSBased on results from preclinical studies on dantrolene sodium and ongoing longitudinal studies, we assembled what we believe is the first-ever clinical trial in pediatric and adult Wolfram syndrome patients with an open-label phase Ib/IIa trial design. The primary objective was to assess the safety and tolerability of dantrolene sodium in adult and pediatric Wolfram syndrome patients. Secondary objectives were to evaluate the efficacy of dantrolene sodium on residual pancreatic β cell functions, visual acuity, quality-of-life measures related to vision, and neurological functions.RESULTSDantrolene sodium was well tolerated by Wolfram syndrome patients. Overall, β cell functions were not significantly improved, but there was a significant correlation between baseline β cell functions and change in β cell responsiveness (R2, P = 0.004) after 6-month dantrolene therapy. Visual acuity and neurological functions were not improved by 6-month dantrolene sodium. Markers of inflammatory cytokines and oxidative stress, such as IFN-γ, IL-1β, TNF-α, and isoprostane, were elevated in subjects.CONCLUSIONThis study justifies further investigation into using dantrolene sodium and other small molecules targeting the ER for treatment of Wolfram syndrome.TRIAL REGISTRATIONClinicalTrials.gov identifier NCT02829268FUNDINGNIH/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK112921, DK113487, DK020579), NIH/National Center for Advancing Translational Sciences (NCATS) (TR002065, TR000448), NIH training grant (F30DK111070), Silberman Fund, Ellie White Foundation, Snow Foundation, Unravel Wolfram Syndrome Fund, Stowe Fund, Eye Hope Foundation, Feiock Fund, Washington University Institute of Clinical and Translational Sciences grant UL1TR002345 from NIH/NCATS, Bursky Center for Human Immunology & Immunotherapy Programs

EuPathDB: the eukaryotic pathogen genomics database resource

The Eukaryotic Pathogen Genomics Database Resource (EuPathDB, http://eupathdb.org) is a collection of databases covering 170+ eukaryotic pathogens (protists & fungi), along with relevant free-living and non-pathogenic species, and select pathogen hosts. To facilitate the discovery of meaningful biological relationships, the databases couple preconfigured searches with visualization and analysis tools for comprehensive data mining via intuitive graphical interfaces and APIs. All data are analyzed with the same workflows, including creation of gene orthology profiles, so data are easily compared across data sets, data types and organisms. EuPathDB is updated with numerous new analysis tools, features, data sets and data types. New tools include GO, metabolic pathway and word enrichment analyses plus an online workspace for analysis of personal, non-public, large-scale data. Expanded data content is mostly genomic and functional genomic data while new data types include protein microarray, metabolic pathways, compounds, quantitative proteomics, copy number variation, and polysomal transcriptomics. New features include consistent categorization of searches, data sets and genome browser tracks; redesigned gene pages; effective integration of alternative transcripts; and a EuPathDB Galaxy instance for private analyses of a user's data. Forthcoming upgrades include user workspaces for private integration of data with existing EuPathDB data and improved integration and presentation of host–pathogen interactions

Consensus Statement on Bone Conduction Devices and Active Middle Ear Implants in Conductive and Mixed Hearing Loss

Nowadays, several options are available to treat patients with conductive or mixed hearing loss. Whenever surgical intervention is not possible or contra-indicated, and amplification by a conventional hearing device (e.g., behind-the-ear device) is not feasible, then implantable hearing devices are an indispensable next option. Implantable bone-conduction devices and middle-ear implants have advantages but also limitations concerning complexity/invasiveness of the surgery, medical complications, and effectiveness. To counsel the patient, the clinician should have a good overview of the options with regard to safety and reliability as well as unequivocal technical performance data. The present consensus document is the outcome of an extensive iterative process including ENT specialists, audiologists, health-policy scientists, and representatives/technicians of the main companies in this field. This document should provide a first framework for procedures and technical characterization to enhance effective communication between these stakeholders, improving health care