127 research outputs found
Entanglement of Assistance is not a bipartite measure nor a tripartite monotone
The entanglement of assistance quantifies the entanglement that can be
generated between two parties, Alice and Bob, given assistance from a third
party, Charlie, when the three share a tripartite state and where the
assistance consists of Charlie initially performing a measurement on his share
and communicating the result to Alice and Bob through a one-way classical
channel. We argue that if this quantity is to be considered an operational
measure of entanglement, then it must be understood to be a tripartite rather
than a bipartite measure. We compare it with a distinct tripartite measure that
quantifies the entanglement that can be generated between Alice and Bob when
they are allowed to make use of a two-way classical channel with Charlie. We
show that the latter quantity, which we call the entanglement of collaboration,
can be greater than the entanglement of assistance. This demonstrates that the
entanglement of assistance (considered as a tripartite measure of
entanglement), and its multipartite generalizations such as the localizable
entanglement, are not entanglement monotones, thereby undermining their
operational significance.Comment: 5 pages, revised, title changed, added a discussion explaining why
entanglement of assistance can not be considered as a bipartite measure, to
appear in Phys. Rev.
Deterministic Entanglement of Assistance and Monogamy Constraints
Certain quantum information tasks require entanglement of assistance, namely
a reduction of a tripartite entangled state to a bipartite entangled state via
local measurements. We establish that 'concurrence of assistance' (CoA)
identifies capabilities and limitations to producing pure bipartite entangled
states from pure tripartite entangled states and prove that CoA is an
entanglement monotone for -dimensional pure states.
Moreover, if the CoA for the pure tripartite state is at least as large as the
concurrence of the desired pure bipartite state, then the former may be
transformed to the latter via local operations and classical communication, and
we calculate the maximum probability for this transformation when this
condition is not met.Comment: 5 pages, no figure
Organ-specific responses during brain death:increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys
Hepatic and renal energy status prior to transplantation correlates with graft survival. However, effects of brain death (BD) on organ-specific energy status are largely unknown. We studied metabolism, perfusion, oxygen consumption, and mitochondrial function in the liver and kidneys following BD. BD was induced in mechanically-ventilated rats, inflating an epidurally-placed Fogarty-catheter, with sham-operated rats as controls. A 9.4T-preclinical MRI system measured hourly oxygen availability (BOLD-related R2*) and perfusion (T1-weighted). After 4 hrs, tissue was collected, mitochondria isolated and assessed with high-resolution respirometry. Quantitative proteomics, qPCR, and biochemistry was performed on stored tissue/plasma. Following BD, the liver increased glycolytic gene expression (Pfk-1) with decreased glycogen stores, while the kidneys increased anaerobic- (Ldha) and decreased gluconeogenic-related gene expression (Pck-1). Hepatic oxygen consumption increased, while renal perfusion decreased. ATP levels dropped in both organs while mitochondrial respiration and complex I/ATP synthase activity were unaffected. In conclusion, the liver responds to increased metabolic demands during BD, enhancing aerobic metabolism with functional mitochondria. The kidneys shift towards anaerobic energy production while renal perfusion decreases. Our findings highlight the need for an organ-specific approach to assess and optimise graft quality prior to transplantation, to optimise hepatic metabolic conditions and improve renal perfusion while supporting cellular detoxification
Entanglement in Many-Body Systems
The recent interest in aspects common to quantum information and condensed
matter has prompted a prosperous activity at the border of these disciplines
that were far distant until few years ago. Numerous interesting questions have
been addressed so far. Here we review an important part of this field, the
properties of the entanglement in many-body systems. We discuss the zero and
finite temperature properties of entanglement in interacting spin, fermionic
and bosonic model systems. Both bipartite and multipartite entanglement will be
considered. At equilibrium we emphasize on how entanglement is connected to the
phase diagram of the underlying model. The behavior of entanglement can be
related, via certain witnesses, to thermodynamic quantities thus offering
interesting possibilities for an experimental test. Out of equilibrium we
discuss how to generate and manipulate entangled states by means of many-body
Hamiltonians.Comment: 61 pages, 29 figure
Many body physics from a quantum information perspective
The quantum information approach to many body physics has been very
successful in giving new insight and novel numerical methods. In these lecture
notes we take a vertical view of the subject, starting from general concepts
and at each step delving into applications or consequences of a particular
topic. We first review some general quantum information concepts like
entanglement and entanglement measures, which leads us to entanglement area
laws. We then continue with one of the most famous examples of area-law abiding
states: matrix product states, and tensor product states in general. Of these,
we choose one example (classical superposition states) to introduce recent
developments on a novel quantum many body approach: quantum kinetic Ising
models. We conclude with a brief outlook of the field.Comment: Lectures from the Les Houches School on "Modern theories of
correlated electron systems". Improved version new references adde
Recommended from our members
Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros
This study describes the discovery and characterisation of a novel aminopeptidase A from the venom of B. g. rhinoceros and highlights its potential biological importance. Similar to mammalian aminopeptidases, rhiminopeptidase A might be capable of playing roles in altering the blood pressure and brain function of victims. Furthermore, it could have additional effects on the biological functions of other host proteins by cleaving their N-terminal amino acids. This study points towards the importance of complete analysis of individual components of snake venom in order to develop effective therapies for snake bites
Ultracold atomic gases in optical lattices: mimicking condensed matter physics and beyond
We review recent developments in the physics of ultracold atomic and
molecular gases in optical lattices. Such systems are nearly perfect
realisations of various kinds of Hubbard models, and as such may very well
serve to mimic condensed matter phenomena. We show how these systems may be
employed as quantum simulators to answer some challenging open questions of
condensed matter, and even high energy physics. After a short presentation of
the models and the methods of treatment of such systems, we discuss in detail,
which challenges of condensed matter physics can be addressed with (i)
disordered ultracold lattice gases, (ii) frustrated ultracold gases, (iii)
spinor lattice gases, (iv) lattice gases in "artificial" magnetic fields, and,
last but not least, (v) quantum information processing in lattice gases. For
completeness, also some recent progress related to the above topics with
trapped cold gases will be discussed.Comment: Review article. v2: published version, 135 pages, 34 figure
Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI
BACKGROUND:
Phase-contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood flow values across studies is large, most likely due to differences in PC-MRI acquisition and processing. Standardized acquisition and processing protocols are therefore needed to minimize this variability and maximize the potential of renal PC-MRI as a clinically useful tool.
PURPOSE:
To build technical recommendations for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and facilitate the comparability of results across scanners and in multicenter clinical studies.
STUDY TYPE:
Systematic consensus process using a modified Delphi method.
POPULATION:
Not applicable.
SEQUENCE FIELD/STRENGTH:
Renal fast gradient echo-based 2D PC-MRI.
ASSESSMENT:
An international panel of 27 experts from Europe, the USA, Australia, and Japan with 6 (interquartile range 4–10) years of experience in 2D PC-MRI formulated consensus statements on renal 2D PC-MRI in two rounds of surveys. Starting from a recently published systematic review article, literature-based and data-driven statements regarding patient preparation, hardware, acquisition protocol, analysis steps, and data reporting were formulated.
STATISTICAL TESTS:
Consensus was defined as ≥75% unanimity in response, and a clear preference was defined as 60–74% agreement among the experts.
RESULTS:
Among 60 statements, 57 (95%) achieved consensus after the second-round survey, while the remaining three showed a clear preference. Consensus statements resulted in specific recommendations for subject preparation, 2D renal PC-MRI data acquisition, processing, and reporting.
DATA CONCLUSION:
These recommendations might promote a widespread adoption of renal PC-MRI, and may help foster the set-up of multicenter studies aimed at defining reference values and building larger and more definitive evidence, and will facilitate clinical translation of PC-MRI.
LEVEL OF EVIDENCE:
1
TECHNICAL EFFICACY STAGE:
Tracer input for kinetic modelling of liver physiology determined without sampling portal venous blood in pigs
A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency
The established causal genes in Alzheimer’s disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. Mutations in SORL1, encoding the endosome recycling receptor SORLA, are found in 2%–3% of individuals with early-onset AD, and SORL1 haploinsufficiency appears to be causal for AD. To test whether SORL1 can function as an AD causal gene, we use CRISPR-Cas9-based gene editing to develop a model of SORL1 haploinsufficiency in Göttingen minipigs, taking advantage of porcine models for biomarker investigations. SORL1 haploinsufficiency in young adult minipigs is found to phenocopy the preclinical in vivo profile of AD observed with APP, PSEN1, and PSEN2, resulting in elevated levels of β-amyloid (Aβ) and tau preceding amyloid plaque formation and neurodegeneration, as observed in humans. Our study provides functional support for the theory that SORL1 haploinsufficiency leads to endosome cytopathology with biofluid hallmarks of autosomal dominant AD
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