81 research outputs found
Hypoxia-inducible factor (HIF1α) gene expression in human shock states.
International audienceABSTRACT: INTRODUCTION: Hypoxia-inducible factor-1 (HIF1) controls the expression of genes involved in the cellular response to hypoxia. No information is available on its expression in critically ill patients. Thus, we designed the first clinical study in order to evaluate the role of HIF1α as a prognosis marker in patients suffering from shock. METHODS: Fifty consecutive adult patients with shock and 11 healthy volunteers were prospectively enrolled in the study. RNA was extracted from whole blood samples and expression of HIF1α was assessed over the first four hours of shock. The primary objective was to assess HIF1α as a prognostic marker in shock. Secondary objectives were to evaluate the role of HIF1α as a diagnostic and follow-up marker. Patient survival was evaluated at day 28. RESULTS: The causes of shock were sepsis (78%), hemorrhage (18%), and cardiac dysfunction (4%). HIF1α expression was significantly higher in the shock patients than in the healthy volunteers (121 (range: 72-168) versus 48 (range: 38-54) normalized copies, P <0.01), whatever the measured isoforms. It was similar in non-survivors and survivors (108 (range 84-183) versus 121(range 72-185) normalized copies, P = 0.92), and did not significantly change within the study period. CONCLUSIONS: The present study is the first to demonstrate an increased expression of HIF1α in patients with shock. Further studies are needed to clarify the potential association with outcome. Our findings reinforce the value of monitoring plasma lactate levels to guide the treatment of shock
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus.
COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung
ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging,
diagnosis and medical management of COVID-19 patients. The expert panel from 27 countries and 6 continents with
considerable experience of direct application of PoCUS on COVID-19 patients presents evidence-based consensus
using GRADE methodology for the quality of evidence and an expedited, modified-Delphi process for the strength of
expert consensus. The use of ultrasound is suggested in many clinical situations related to respiratory, cardiovascular
and thromboembolic aspects of COVID-19, comparing well with other imaging modalities. The limitations due to
insufficient data are highlighted as opportunities for future research.post-print2.282 K
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus
COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 countries and 6 continents with considerable experience of direct application of PoCUS on COVID-19 patients presents evidence-based consensus using GRADE methodology for the quality of evidence and an expedited, modified-Delphi process for the strength of expert consensus. The use of ultrasound is suggested in many clinical situations related to respiratory, cardiovascular and thromboembolic aspects of COVID-19, comparing well with other imaging modalities. The limitations due to insufficient data are highlighted as opportunities for future research
Diaphragmatic ultrasound cannot replace medical reasoning
IF 1.542International audienc
A picture’s worth a thousand words: speckle tracking for quantification and assessment of lung sliding
International audienc
Beta-blockers in septic shock: a magnifying glass on the relation heart vessel
International audienceno abstrac
Antimicrobial prophylaxis is critical for preventing surgical site infection
International audienc
Concordance of longitudinal strain and MRI in a case of myocardial contusion in a patient with normal conventional 2D echocardiography
International audienc
Semi-quantitative ultrasound grading system to discriminate between low and high gastric fluid volume in third-trimester pregnant women
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