The advertising and marketing of the Edwardian prize book: Gender for sale

This article uses the prize book catalogues of six major British religious and secular publishers of the Edwardian era to explore the advertisement and marketing of gender in the early twentieth century. In particular, it is concerned with how boys and girls were framed by advertisements and whether differences existed according to the beliefs of each publishing house. It also investigates attitudes towards books and their context of use, as well as their strategy of appeal and the values invoked by phrasing. It demonstrates that through their linguistic choices, stereotyping and ideologies, both secular and religious publishers played a key role in the development of a distinct boys’ culture and girls’ culture in Edwardian Britain. While girls were cast into submissive roles based on righteousness and respectability, boys were marketed as the superior sex who had a moral responsibility to advocate Britishness, imperialism and heroism. The analysis shows how mail-order catalogues acted as a precursor to modern mass media, suggesting continuity rather than change in the world of advertisin

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

A PrPC-caveolin-Lyn complex negatively controls neuronal GSK3β and serotonin 1B receptor

The cellular prion protein, PrP(C), is a glycosylphosphatidylinositol-anchored protein, abundant in lipid rafts and highly expressed in the brain. While PrP(C) is much studied for its involvement under its abnormal PrP(Sc) isoform in Transmissible Spongiform Encephalopathies, its physiological role remains unclear. Here, we report that GSK3β, a multifunctional kinase whose inhibition is neuroprotective, is a downstream target of PrP(C) signalling in serotonergic neuronal cells. We show that the PrP(C)-dependent inactivation of GSK3β is relayed by a caveolin-Lyn platform located on neuronal cell bodies. Furthermore, the coupling of PrP(C) to GSK3β potentiates serotonergic signalling by altering the distribution and activity of the serotonin 1B receptor (5-HT(1B)R), a receptor that limits neurotransmitter release. In vivo, our data reveal an increased GSK3β kinase activity in PrP-deficient mouse brain, as well as sustained 5-HT(1B)R activity, whose inhibition promotes an anxiogenic behavioural response. Collectively, our data unveil a new facet of PrP(C) signalling that strengthens neurotransmission