1,065 research outputs found
Theory of pressure acoustics with boundary layers and streaming in curved elastic cavities
The acoustic fields and streaming in a confined fluid depend strongly on the
acoustic boundary layer forming near the wall. The width of this layer is
typically much smaller than the bulk length scale set by the geometry or the
acoustic wavelength, which makes direct numerical simulations challenging.
Based on this separation in length scales, we extend the classical theory of
pressure acoustics by deriving a boundary condition for the acoustic pressure
that takes boundary-layer effects fully into account. Using the same
length-scale separation for the steady second-order streaming, and combining it
with time-averaged short-range products of first-order fields, we replace the
usual limiting-velocity theory with an analytical slip-velocity condition on
the long-range streaming field at the wall. The derived boundary conditions are
valid for oscillating cavities of arbitrary shape and wall motion as long as
the wall curvature and displacement amplitude are both sufficiently small.
Finally, we validate our theory by comparison with direct numerical simulation
in two examples of two-dimensional water-filled cavities: The well-studied
rectangular cavity with prescribed wall actuation, and the more generic
elliptical cavity embedded in an externally actuated rectangular elastic glass
block.Comment: 18 pages, 5 figures, pdfLatex, RevTe
Acoustic radiation- and streaming-induced microparticle velocities determined by micro-PIV in an ultrasound symmetry plane
We present micro-PIV measurements of suspended microparticles of diameters
from 0.6 um to 10 um undergoing acoustophoresis in an ultrasound symmetry plane
in a microchannel. The motion of the smallest particles are dominated by the
Stokes drag from the induced acoustic streaming flow, while the motion of the
largest particles are dominated by the acoustic radiation force. For all
particle sizes we predict theoretically how much of the particle velocity is
due to radiation and streaming, respectively. These predictions include
corrections for particle-wall interactions and ultrasonic thermoviscous
effects, and they match our measurements within the experimental uncertainty.
Finally, we predict theoretically and confirm experimentally that the ratio
between the acoustic radiation- and streaming-induced particle velocities is
proportional to the square of the particle size, the actuation frequency and
the acoustic contrast factor, while it is inversely proportional to the
kinematic viscosity.Comment: 11 pages, 9 figures, RevTex 4-
Attosecond electron-spin dynamics in Xe 4d photoionization
The photoionization of xenon atoms in the 70-100 eV range reveals several
fascinating physical phenomena such as a giant resonance induced by the dynamic
rearrangement of the electron cloud after photon absorption, an anomalous
branching ratio between intermediate Xe states separated by the spin-orbit
interaction and multiple Auger decay processes. These phenomena have been
studied in the past, using in particular synchrotron radiation, but without
access to real-time dynamics. Here, we study the dynamics of Xe 4d
photoionization on its natural time scale combining attosecond interferometry
and coincidence spectroscopy. A time-frequency analysis of the involved
transitions allows us to identify two interfering ionization mechanisms: the
broad giant dipole resonance with a fast decay time less than 50 as and a
narrow resonance at threshold induced by spin-flip transitions, with much
longer decay times of several hundred as. Our results provide new insight into
the complex electron-spin dynamics of photo-induced phenomena
Ultrasonography and color Doppler in juvenile idiopathic arthritis: diagnosis and follow-up of ultrasound-guided steroid injection in the wrist region. A descriptive interventional study
<p>Abstract</p> <p>Background</p> <p>The wrist region is one of the most complex joints of the human body. It is prone to deformity and functional impairment in juvenile idiopathic arthritis (JIA), and is difficult to examine clinically. The aim of this study was to evaluate the role of ultrasonography (US) with Doppler in diagnosis of synovitis, guidance of steroid injections, and follow-up examinations of the wrist in JIA.</p> <p>Methods</p> <p>In 11 patients (median age 12.5 years, range 2-16), 15 wrists with clinically active arthritis were assessed clinically by US and color Doppler (Logiq 9, GE, 16-4 MHz linear transducer) prior to and 1 and 4 weeks after US-guided steroid injection.</p> <p>Results</p> <p>US detected synovitis in the radio-carpal joints, the midcarpal joints, and the tendon sheaths in 87%, 53% and 33% of the wrists, respectively. Multiple compartments were involved in 67%. US-guidance allowed accurate placement of steroid in all 21 injected compartments, with a low rate of subcutaneous atrophy. Synovial hypertrophy was normalized in 86% of the wrists, hyperemia in 91%, and clinically active arthritis in 80%.</p> <p>Conclusions</p> <p>US enabled detection of synovial inflammation in compartments that are difficult to evaluate clinically and exact guidance of injections, and it was valuable for follow-up examinations. Normalization of synovitis was achieved in most cases, which supports the notion that US is an important tool in management of wrist involvement in JIA.</p
Twenty-Five Years of Convoluted Health Reforms in Mexico
Núria Homedes and Antonio Ugalde discuss 25 years of reform to the Mexican health care system and argue that although costs and accessibility have increased, health inequities, efficiency, productivity, and quality of care have not improved
Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue
Five-year survival for patients with oral cancer has been disappointingly stable during the last decades, creating a demand for new biomarkers and treatment targets. Lately, much focus has been set on immunomodulation as a possible treatment or an adjuvant increasing sensitivity to conventional treatments. The objective of this study was to evaluate the prognostic importance of response to radiotherapy in tongue carcinoma patients as well as the expression of the CXC-chemokines in correlation to radiation response in the same group of tumours. Thirty-eight patients with tongue carcinoma that had received radiotherapy followed by surgery were included. The prognostic impact of pathological response to radiotherapy, N-status, T-stage, age and gender was evaluated using Cox's regression models, Kaplan-Meier survival curves and chi-square test. The expression of 23 CXC-chemokine ligands and their receptors were evaluated in all patients using microarray and qPCR and correlated with response to treatment using logistic regression. Pathological response to radiotherapy was independently associated to overall survival with a 2-year survival probability of 81 % for patients showing a complete pathological response, while patients with a non-complete response only had a probability of 42 % to survive for 2 years (p = 0.016). The expression of one CXC-chemokine, CXCL10, was significantly associated with response to radiotherapy and the group of patients with the highest CXCL10 expression responded, especially poorly (p = 0.01). CXCL10 is a potential marker for response to radiotherapy and overall survival in patients with squamous cell carcinoma of the tongue
Integrated acoustic immunoaffinity-capture (IAI) platform for detection of PSA from whole blood samples.
On-chip detection of low abundant protein biomarkers is of interest to enable point-of-care diagnostics. Using a simple form of integration, we have realized an integrated microfluidic platform for the detection of prostate specific antigen (PSA), directly in anti-coagulated whole blood. We combine acoustophoresis-based separation of plasma from undiluted whole blood with a miniaturized immunoassay system in a polymer manifold, demonstrating improved assay speed on our Integrated Acoustic Immunoaffinity-capture (IAI) platform. The IAI platform separates plasma from undiluted whole blood by means of acoustophoresis and provides cell free plasma of clinical quality at a rate of 10 uL/min for an online immunoaffinity-capture of PSA on a porous silicon antibody microarray. The whole blood input (hematocrit 38-40%) rate was 50 μl min(-1) giving a plasma volume fraction yield of ≈33%. PSA was immunoaffinity-captured directly from spiked female whole blood samples at clinically significant levels of 1.7-100 ng ml(-1) within 15 min and was subsequently detected via fluorescence readout, showing a linear response over the entire range with a coefficient of variation of 13%
Ultra-stable and versatile high-energy resolution setup for attosecond photoelectron spectroscopy
Attosecond photoelectron spectroscopy is often performed with interferometric
experimental setups that require outstanding stability. We demonstrate and
characterize in detail an actively stabilized, versatile, high spectral
resolution attosecond beamline. The active-stabilization system can remain
ultra-stable for several hours with an RMS stability of 13 as and a total
pump-probe delay scanning range of \sim 400 fs. A tunable femtosecond laser
source to drive high-order harmonic generation allows for precisely addressing
atomic and molecular resonances. Furthermore, the interferometer includes a
spectral shaper in 4f-geometry in the probe arm as well as a tunable bandpass
filter in the pump arm, which offer additional high flexibility in terms of
tunability as well as narrowband or polychromatic probe pulses. We show that
spectral phase measurements of photoelectron wavepackets with the rainbow
RABBIT technique (reconstruction of attosecond beating by two photon
transitions) with narrowband probe pulses can significantly improve the
photoelectron energy resolution. In this setup, the temporal-spectral
resolution of photoelectron spectroscopy can reach a new level of accuracy and
precision
- …