Core Competencies and Christian Education: An Integrative Approach to Education in Marriage and Family Therapy Programs

For educating marriage and family therapy (MFT) students, there has been an increasing emphasis on their ability to demonstrate a series of core competencies as identified by the American Associate for Marriage and Family (AAMFT) (Nelson et al., 2007). This type of therapist education from outcome-based education (OBE) fosters the characteristics or worldview associated with educational institutions and the profession. At the most general level, OBE is education or socialization into the professional MFT worldview. As a corrective to this, there is a need to seek this moral character in a Christian worldview which emphasizes a metanarrative informed by the Bible as well as Christian tradition. Therefore, moral character must be identified and developed in a Christian moral community. This Christian moral education and participation in moral community encourage Christian virtues such as faith, hope, and love

CoA protects against the deleterious effects of caloric overload in Drosophila

We developed a Drosophila model of T2D in which high sugar (HS) feeding leads to insulin resistance. In this model, adipose TG storage is protective against fatty acid toxicity and diabetes. Initial biochemical and gene expression studies suggested that deficiency in CoA might underlie reduced TG synthesis in animals during chronic HS feeding. Focusing on the Drosophila fat body (FB), which is specialized for TG storage and lipolysis, we undertook a series of experiments to test the hypothesis that CoA could protect against the deleterious effects of caloric overload. Quantitative metabolomics revealed a reduction in substrate availability for CoA synthesis in the face of an HS diet. Further reducing CoA synthetic capacity by expressing FB-specific RNAi targeting pantothenate kinase (PK orfumble) or phosphopantothenoylcysteine synthase (PPCS) exacerbated HS-diet-induced accumulation of FFAs. Dietary supplementation with pantothenic acid (vitamin B5, a precursor of CoA) was able to ameliorate HS-diet-induced FFA accumulation and hyperglycemia while increasing TG synthesis. Taken together, our data support a model where free CoA is required to support fatty acid esterification and to protect against the toxicity of HS diets

A Framework for Reducing the College Success Gap and Promoting Success for All

Policymakers, practitioners, and scholars have directed tremendous attention to the goal of improving “student success.” Based on a review of largely discrete existing bodies of literature, this report proposes an overarching framework that policymakers, practitioners, and researchers can use to develop, implement, and evaluate policies and practices for addressing persistent racial/ethnic and socioeconomic gaps in student success. The framework brings order to the wide array of theoretical and methodological approaches that, when considered together, provide a comprehensive understanding of the ways policymakers and practitioners can intervene more effectively to promote student success. The framework was intended to describe avenues and approaches to effective development, implementation, and evaluation of policy related to student success, eschewing the identification of a “single bullet” theory, method, policy, or practice. After defining student success and explaining our procedures, this report describes the results of a multidisciplinary examination of the theoretical and methodological approaches that researchers have used to inform knowledge and understanding across a range of student success outcomes. Then, the report presents and describes the proposed conceptual model that ties this work together and provides recommended uses of the model for policy, practice, and further research

A genetic and molecular model for flower development in Arabidopsis thaliana

Cells in developing organisms do not only differentiate, they differentiate in defined patterns. A striking example is the differentiation of flowers, which in most plant families consist of four types of organs: sepals, petals, stamens and carpels, each composed of characteristic cell types. In the families of flowering plants in which these organs occur, they are patterned with the sepals in the outermost whorl or whorls of the flower, with the petals next closest to the center, the stamens even closer to the center, and the carpels central. In each species of flowering plant the disposition and number (or range of numbers) of these organs is also specified, and the floral 'formula' is repeated in each of the flowers on each individual plant of the species. We do not know how cells in developing plants determine their position, and in response to this determination differentiate to the cell types appropriate for that position. While there have been a number of speculative proposals for the mechanism of organ specification in flowers (Goethe, 1790; Goebel, 1900; Heslop-Harrison, 1964; Green, 1988), recent genetic evidence is inconsistent with all of them, at least in the forms in which they were originally presented (Bowman et al. 1989; Meyerowitz et al. 1989). We describe here a preliminary model, based on experiments with Arabidopsis thaliana. The model is by and large consistent with existing evidence, and has predicted the results of a number of genetic and molecular experiments that have been recently performed

Similar effects of high-fructose and high-glucose feeding in a Drosophila model of obesity and diabetes

As in mammals, high-sucrose diets lead to obesity and insulin resistance in the model organism Drosophila melanogaster (called Drosophila hereafter). To explore the relative contributions of glucose and fructose, sucrose’s component monosaccharides, we compared their effects on larval physiology. Both sugars exhibited similar effects to sucrose, leading to obesity and hyperglycemia. There were no striking differences resulting from larvae fed high glucose versus high fructose. Some small but statistically significant differences in weight and gene expression were observed that suggest Drosophila is a promising model system for understanding monosaccharide-specific effects on metabolic homeostasis.</div

Activity-dependent trafficking of lysosomes in dendrites and dendritic spines.

In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily reside in somatic and axonal compartments, but there is little understanding of their distribution and function in dendrites. Here, we used conventional and two-photon imaging and electron microscopy to show that lysosomes traffic bidirectionally in dendrites and are present in dendritic spines. We find that lysosome inhibition alters their mobility and also decreases dendritic spine number. Furthermore, perturbing microtubule and actin cytoskeletal dynamics has an inverse relationship on the distribution and motility of lysosomes in dendrites. We also find trafficking of lysosomes is correlated with synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors. Strikingly, lysosomes traffic to dendritic spines in an activity-dependent manner and can be recruited to individual spines in response to local activation. These data indicate the position of lysosomes is regulated by synaptic activity and thus plays an instructive role in the turnover of synaptic membrane proteins

The Very Light Jet Arrives: Stakeholders and Their Perceptions

This article summarizes the initial results of a systematic study that addressed issues related to the direct and indirect market impact of very light jet (VLJ) aircraft. Although reports in the popular press offer wide-ranging estimates of the impact that these new jets will have on existing air travel, no systematic data exists that may be of use to all potential stakeholders. This introductory study serves to describe potential VLJ users and their perceptions of this new type of aircraft