A stereoselective, catalytic strategy for the in-flow synthesis of advanced precursors of rasagiline and tamsulosin

The diastereoselective, trichlorosilane-mediate reduction of imines, bearing different and removable chiral auxiliaries, in combination either with achiral bases or catalytic amounts of chiral Lewis bases, was investigated to afford immediate precursors of chiral APIs (Active Pharmaceutical Ingredients). The carbon-nitrogen double bond reduction was successfully performed in batch and in flow mode, in high yields and almost complete stereocontrol. By this metal-free approach, the formal synthesis of rasagiline and tamsulosin was successfully accomplished in micro(meso) flow reactors, under continuous flow conditions. The results of these explorative studies represent a new, important step towards the development of automated processes for the preparation of enantiopure biologically active compound

NASA GRC Compass Team Conceptual Point Design and Trades of a Hybrid Solar Electric Propulsion (SEP)/Chemical Propulsion Human Mars Deep Space Transport (DST) Vehicle

NASA has long been conducting studies which apply different in-space propulsion technology assumptions to the mission of sending humans to Mars. Two of the technologies under study that are considered to be the most near-term with respect to technology readiness level (TRL) are traditional chemical propulsion systems and high-power Solar Electric Propulsion (SEP) systems. The benefit of relatively low trip times inherent in using impulsive chemical propulsion systems to perform the full round-trip delta V is hampered by the large propellant mass required to perform these burns for human Mars missions. SEP systems offer the benefit of much lower propellant requirements to perform the same round-trip missions, at the cost of longer trip times. Traditionally, impulsive chemical systems are better suited than SEP when used in a gravity well, and SEP systems are more efficient than traditional impulsive systems when used in interplanetary space. A mission to Mars includes both of these scenarios, and thus several NASA architecture studies performed over the last few years have looked to combine the use of both SEP and chemical propulsion systems where they are the most beneficial to human Mars missions. This combined propulsion system concept has been referred to as a SEP/Chem hybrid Mars Transfer Vehicle and is currently shown as the concept Deep Space Transport (DST) in the March 2017 NASA presentation to the National Aerospace Council (NAC)

Spatial Orientation And Distribution Of Reservoir Fractures From Scattered Seismic Energy

Shortened title: Fracture characterization from coda wavesWe present the details of a new method for determining the reflection and scattering characteristics of seismic energy from subsurface fractured formations. The method is based upon observations we have made from 3D finite difference modeling of the reflected and scattered seismic energy over discrete systems of vertical fractures. Regularly spaced, discrete vertical fractures impart a ringing coda type signature to any seismic energy which is transmitted through or reflected off of them. This signature varies in amplitude and coherence as a function of several parameters including: 1) the difference in angle between the orientation of the fractures and the acquisition direction, 2) the fracture spacing, 3) the wavelength of the illuminating seismic energy, and 4) the compliance, or stiffness, of the fractures. This coda energy is the most coherent when the acquisition direction is parallel to the strike of the fractures. It has the largest amplitude when the seismic wavelengths are tuned to the fracture spacing, and when the fractures have low stiffness. Our method uses surface seismic reflection traces to derive a transfer function which quantifies the change in an apparent source wavelet before and after propagating through a fractured interval. The transfer function for an interval with no or low amounts of scattering will be more spike-like and temporally compact. The transfer function for an interval with high scattering will ring and be less temporally compact. When a 3D survey is acquired with a full range of azimuths, the variation in the derived transfer functions allows us to identify subsurface areas with high fracturing and determine the strike of those fractures. We calibrated the method with model data and then applied it to the Emilio field with a fractured reservoir giving results which agree with known field measurements and previously published fracture orientations derived from PS anisotropy.Eni S.p.A. (Firm)United States. Dept. of Energy (Grant number DE-FC26-02NT15346)Massachusetts Institute of Technology. Earth Resources Laborator

Miniaturized data loggers and computer programming improve seabird risk and damage assessments for marine oil spills in Atlantic Canada

Obtaining useful information on marine birds that can aid in oil spill (and other hydrocarbon release) risk and damage assessments in offshore environments is challenging. Technological innovations in miniaturization have allowed archival data loggers to be deployed successfully on marine birds vulnerable to hydrocarbons on water. A number of species, including murres (both Common, Uria aalge, and Thick-billed, U. lomvia) have been tracked using geolocation devices in eastern Canada, increasing our knowledge of the seasonality and colony-specific nature of their susceptibility to oil on water in offshore hydrocarbon production areas and major shipping lanes. Archival data tags are starting to resolve questions around behaviour of vulnerable seabirds at small spatial scales relevant to oil spill impact modelling, specifically to determine the duration and frequency at which birds fly at sea. Advances in data capture methods using voice activated software have eased the burden on seabird observers who are collecting increasingly more detailed information on seabirds during ship-board and aerial transects. Computer programs that integrate seabird density and bird behaviour have been constructed, all with a goal of creating more credible seabird oil spill risk and damage assessments. In this paper, we discuss how each of these technological and computing innovations can help define critical inputs into seabird risk and damage assessments, and when combined, can provide a more realistic understanding of the impacts to seabirds from any hydrocarbon release

Low Thrust Cis-Lunar Transfers Using a 40 kW-Class Solar Electric Propulsion Spacecraft

This paper captures trajectory analysis of a representative low thrust, high power Solar Electric Propulsion (SEP) vehicle to move a mass around cis-lunar space in the range of 20 to 40 kW power to the Electric Propulsion (EP) system. These cis-lunar transfers depart from a selected Near Rectilinear Halo Orbit (NRHO) and target other cis-lunar orbits. The NRHO cannot be characterized in the classical two-body dynamics more familiar in the human spaceflight community, and the use of low thrust orbit transfers provides unique analysis challenges. Among the target orbit destinations documented in this paper are transfers between a Southern and Northern NRHO, transfers between the NRHO and a Distant Retrograde Orbit (DRO) and a transfer between the NRHO and two different Earth Moon Lagrange Point 2 (EML2) Halo orbits. Because many different NRHOs and EML2 halo orbits exist, simplifying assumptions rely on previous analysis of orbits that meet current abort and communication requirements for human mission planning. Investigation is done into the sensitivities of these low thrust transfers to EP system power. Additionally, the impact of the Thrust to Weight ratio of these low thrust SEP systems and the ability to transit between these unique orbits are investigated

Patients' Choices for Return of Exome Sequencing Results to Relatives in the Event of Their Death

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116009/1/jlme12290.pd

Radiocarbon evidence for the stability of polar ocean overturning during the Holocene

Funding: T.C. acknowledges support from the Strategic Priority Research Program of Chinese Academy of Sciences (XDB40010200), Fundamental Research Funds for the Central Universities (020614380116) and National Natural Science Foundation of China (41991325, 41822603 and 42021001). L.F.R. acknowledges support from the Natural Environment Research Council (NE/S001743/1, NE/R005117/1, NE/N003861/1 and NE/X00127X/1).Proxy-based studies have linked the pre-industrial atmospheric pCO2 rise of ∼20 ppmv in the mid- to late Holocene to an inferred increase in the Southern Ocean overturning and associated biogeochemical changes. However, the history of polar ocean overturning and ventilation through the Holocene remains poorly constrained, leaving important gaps in the assessment of the feedbacks between changes in ocean circulation and the carbon cycle in a warm climate state. The deep-ocean radiocarbon content, which provides a measure of ventilation, responds to circulation changes on centennial to millennial time scales. Here we present absolutely dated deep-sea coral radiocarbon records from the Drake Passage, between South America and Antarctica, and Reykjanes Ridge, south of Iceland, over the Holocene. Our data suggest that ventilation in the Antarctic circumpolar waters and North Atlantic Deep Water is surprisingly invariant within proxy uncertainties at our sampling resolution. Our findings indicate that long-term, large-scale polar ocean overturning has not been disturbed to a level resolvable by radiocarbon and is probably not responsible for the millennial atmosphere pCO2 evolution through the Holocene. Instead, continuous nutrient and carbon redistribution within the water column following deglaciation, as well as changes in land organic carbon stock, might have regulated atmospheric CO2 budget during this period.Publisher PDFPeer reviewe