An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e.g., Alzheimer disease, Parkinson disease, multiple sclerosis, motor neuron disease, ischemia and traumatic brain injury, depression, and autism spectrum disorder] nervous systems. The existence of extensive lines of communication between the nervous system and immune system represents a fundamental principle underlying neuroinflammation. Immune cell-derived inflammatory molecules are critical for regulation of host responses to inflammation. Although these mediators can originate from various non-neuronal cells, important sources in the above neuropathologies appear to be microglia and mast cells, together with astrocytes and possibly also oligodendrocytes. Understanding neuroinflammation also requires an appreciation that non-neuronal cell-cell interactions, between both glia and mast cells and glia themselves, are an integral part of the inflammation process. Within this context the mast cell occupies a key niche in orchestrating the inflammatory process, from initiation to prolongation. This review will describe the current state of knowledge concerning the biology of neuroinflammation, emphasizing mast cell-glia and glia-glia interactions, then conclude with a consideration of how a cell's endogenousmechanisms might be leveraged to provide a therapeutic strategy to target neuroinflammation

Some notes on outro in Portuguese

This paper studies the syntactic behavior of outro(s) in Brazilian and European Portuguese. Starting from the syntax of its Italian counterpart un altro/(degli) altri, we argue that outro(s) in prenominal position is neither an adjective nor a determiner, but an existential quantifier and that the presence of the indefinite article, um outro/uns outros, gives rise to a complex existential quantifier, like the corresponding Italian form. We also argue that outro(s) and um outro/uns outros do not specialize for different interpretations since they both substantially show the same ambiguity (one/some more or a/some different one(s)) and behave in the same way in relation to possible semantic interpretations typical of existential quantifiers

Rethinking Lyric Communities

From the circulation of poetic forms across different languages and traditions around the globe, through the envisioning of national and transnational discursive communities, to the use of poetry in contemporary episodes of political resistance and its dissemination on social media, lyric poetry seems to be a privileged site for an inquiry into community formation and its politics. Various theoretical approaches cast poetry in this peculiar role, from French and French-oriented political philosophy, (exemplified in the famous exchange between Maurice Blanchot and Jean-Luc Nancy begun in the 1980s), to the reevaluations — in reader-response criticism as well as in postcolonial and decolonial studies — of poetry’s roots in orality and performance. This workshop aims to bring the investigation of historical poetic communities into dialogue with recent developments in the theory of the lyric and in theories of community. While discussing a variety of poetic phenomena in modern European poetry that have been at the center of the critical debate — the poetics of the fragment, the unworking or désœuvrement of the work, the obscurity or polysemy of language, a change of aesthetic regime —, the workshop will also explore the lyric, in its longer history and transnational features, as a particular discursive mode that may offer alternative models of community formation. This symposium consists of three parts: an Oxford session at the Christ Church Research Centre, on 23 June 2022, a Berlin session at the ICI Berlin, on 5 July, and a poetry event, also on 5 July, at the ICI Berlin with Vahni Anthony Capildeo, Christian Hawkey, and Daniel Tiffany, who will read a selection of their poetry and offer their reflections on poetry, community and translation.Rethinking Lyric Communities, symposium, ICI Berlin, 5 July 2022 <https://doi.org/10.25620/e220705

Dynamic load balancing in parallel processing on non-homogeneous clusters

This paper analyzes the dynamic and static balancing of non-homogenous cluster architectures, simultaneously analyzing the theoretical parallel Speedup as well as the Speedup experimentally obtained. Three interconnected clusters have been used in which the machines within each cluster have homogeneous processors although different among clusters. Thus, the set can be seen as a 25-processor heterogeneous cluster or as a multi-cluster scheme with subsets of homogeneous processors. A classical application (Parallel N-Queens) with a parallel solution algorithm, where processing predominates upon communication, has been chosen so as to go deep in the load balancing aspects (dynamic or static) without distortion of results caused by communication overhead. At the same time, three forms of load distribution in the processors (Direct Static, Predictive Static and Dynamic by Demand) have been studied, analyzing in each case parallel Speedup and load unbalancing regarding problem size and the processors used.Facultad de Informátic

Parallelization of the N-queens problem : Load unbalance analysis.

The paper presents an analysis of three parallelization structures of the N-queens problem, taking into account N processors. The focus has been set on investigating the adaptation of the architecture structure to the proposed algorithm type, so as to study the load unbalance in each case, for which two different metrics have been established. The experimental results and the efficient implementation of the algorithms are discussed together with the related current research lines.Eje: Procesamiento distribuido y paralelo (PDP)Red de Universidades con Carreras en Informática (RedUNCI

A Study of Hardware Performance Counters Selection for Cross Architectural GPU Power Modeling

In the exascale race where huge corporations are spending billions of dollars on designing highly efficient heterogeneous supercomputers, the real need to reduce power envelopes forces current technologies to face crucial challenges as well as it demands the scientific community to evaluate and optimize the performance-power ratio. While energy consumption continues to climb up, the viability of these massive systems becomes a growing concern. In this context, the relevance of specific power-related research works turns into a priority. So we here develop an exhaustive step-by-step process for selecting a comprehensive set of hardware performance counters to serve as an input in an eventual GPU cross-architectural power consumption model. Our experiments show a high power-performance correlation between shared GPU events. Also, we present a set of events that delivers exclusive performance information in order to predict accurately GPU power fluctuations.XX Workshop Procesamiento Distribuido y Paralelo.Red de Universidades con Carreras en Informátic

Parallelization of image similarity analysis

The algorithmical architecture and structure is presented for the parallelization of image similarity analysis, based on obtaining multiple digital signatures for each image, in which each "signature" is composed by the most representative coefficients of the wavelet transform of the corresponding image area. In the present paper, image representation by wavelet transform coefficients is analyzed, as well as the convenience/necessity of using multiple coefficients for the study of similarity of images which may have transferred components, with change of sizes, color or texture. The complexity of the involved computation justifies parallelization, and the suggested solution constitutes a combination of a multiprocessors "pipelining", being each of them an homogeneous parallel architecture which obtains signature coefficients (wavelet). Partial reusability of computations for successive signatures makes these architectures pipelining compulsory.Facultad de Informátic

A Study of Hardware Performance Counters Selection for Cross Architectural GPU Power Modeling

In the exascale race where huge corporations are spending billions of dollars on designing highly efficient heterogeneous supercomputers, the real need to reduce power envelopes forces current technologies to face crucial challenges as well as it demands the scientific community to evaluate and optimize the performance-power ratio. While energy consumption continues to climb up, the viability of these massive systems becomes a growing concern. In this context, the relevance of specific power-related research works turns into a priority. So we here develop an exhaustive step-by-step process for selecting a comprehensive set of hardware performance counters to serve as an input in an eventual GPU cross-architectural power consumption model. Our experiments show a high power-performance correlation between shared GPU events. Also, we present a set of events that delivers exclusive performance information in order to predict accurately GPU power fluctuations.XX Workshop Procesamiento Distribuido y Paralelo.Red de Universidades con Carreras en Informátic