When I Meet MacKay

Contains advertisements and/or short musical examples of pieces being sold by publisher.https://digitalcommons.library.umaine.edu/mmb-vp/7135/thumbnail.jp

Variation of tow force with velocity during offshore ploughing in granular materials

Pipeline plough behaviour has been investigated by means of reduced scale physical model testing. A testing programme was devised to investigate the influence of permeability, relative density, and plough depth on the associated tow force measured during ploughing over a range of velocities in saturated granular material. An increase in tow force with velocity was found during all of the tests and the results have been compared to previously developed analytical models. A new empirical equation has been developed to describe the change in tow force with velocity for a variety of model siliceous sand conditions. Application of this new approach to full-scale ploughing requires consideration of scaling effects and the use of appropriate input parameters determined to replicate field conditions. </jats:p

The influence of incorporating a forecutter on the performance of offshore pipeline ploughs

AbstractInstallation of offshore pipelines in the seabed can be efficiently achieved using pipeline ploughs. Increased efficiency may be achievable through incorporating a smaller forecutter in advance of the main plough share. Currently guidance is limited and conflicting as to the advantages or disadvantages of incorporating a forecutter. To investigate the effect of forecutter inclusion model tests were undertaken at 1/50th scale under laboratory conditions in sand beds prepared at different relative densities in both dry and saturated conditions. Dry sand tests were used to determine the effect of the forecutter on the static or passive components of plough tow force. The currently adopted passive pressure coefficient (Cs) did not appear to vary with relative density to the same degree as previously suggested and the forecutter increased the magnitude of the passive or static resistance to ploughing. Saturated tests were used to determine the effects of the forecutter on the rate dependant component of ploughing resistance and allow verification of a dimensionless form of rate effect representation. The forecutter acts to reduce the rate effect component of plough tow force in both fine sand (low permeability) and to a lesser extent in medium sand (higher permeability). In fine and silty sands, however, incorporating a forecutter would seem highly beneficial at all ploughing depths and soil densities but in medium sand (higher permeability) the benefits of incorporation are limited to an operating window at shallower trench depths and lower relative density

Trixie from Dixie

Illustration of five men in various types of clothing.https://scholarsjunction.msstate.edu/cht-sheet-music/1431/thumbnail.jp

Accounting for Accountability: A Discourse Analysis of Psychiatric Nurses’ Experience of a Patient Suicide

Whilst the experience of a patient suicide is likely to have a significant impact upon the nurses who had been providing care, little work has actually explored this experience in any depth. In this article we explore how two psychiatric nurses construct and orient to accountability when talking of their experiences of a patient suicide. Discourse analysis was used to explore particular phases that the nurses oriented to in their accounts: scene setting; risk assessment; attributing for the suicide. Findings highlight the different, sometimes contradictory, ways the nurses attended to interactional concerns relating to implicit accountability and potential inferences of blame. Analysis of the nurses’ talk can make a valuable contribution to understanding the nature and the impact of ‘accountability’ in a mental health setting and so help nurses and other professionals gain an insight into their practice. The results from this study suggest that as a consequence of internalising fundamentally unrealisable expectations regarding suicide prevention, nurses can hold themselves to blame raising significant concerns around their needs in terms of support, which may not be recognised. This paper also makes a valuable contribution to our methodological understanding and the value of using discourse analysis in this setting

Evaluation of Flying Start NHS

Introduction In January 2006 “Flying Start NHS”, a national web-based educational resource to support the transition from student to qualified practitioner for all newly qualified nurses, midwives and allied health professionals (NMAHP) joining NHS Scotland was launched. This report brings together the findings from a two-year evaluation which focussed on the impact and effectiveness of Flying Start NHS in supporting the recruitment, confidence and skills development of newly qualified nurses, midwives and allied health professionals within NHS Scotland. The evaluation was carried out be a research team from the University of the West of Scotland, the University of Stirling, and the University of Dundee

Effects of non-uniform stiffness on the swimming performance of a passively-flexing, fish-like foil model

Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of IOP Science for personal use, not for redistribution. The definitive version was published in Bioinspiration & Biomimetics 10 (2015): 056019, doi:10.1088/1748-3190/10/5/056019.Simple mechanical models emulating fish have been used recently to enable targeted study of individual factors contributing to swimming locomotion without the confounding complexity of the whole fish body. Yet, unlike these uniform models, the fish body is notable for its non-uniform material properties. In particular, flexural stiffness decreases along the fish’s anterior-posterior axis. To identify the role of non-uniform bending stiffness during fish-like propulsion, we studied four foil model configurations made by adhering layers of plastic sheets to produce discrete regions of high (5.5x10-5 Nm2) and low (1.9x10-5 Nm2) flexural stiffness of biologically-relevant magnitudes. This resulted in two uniform control foils and two foils with anterior regions of high stiffness and posterior regions of low stiffness. With a mechanical flapping foil controller, we measured forces and torques in three directions and quantified swimming performance under both heaving (no pitch) and constant 0o angle of attack programs. Foils self-propelled at Reynolds number 21,000-115,000 and Strouhal number ~0.20-0.25, values characteristic of fish locomotion. Although previous models have emphasized uniform distributions and heaving motions, the combination of non-uniform stiffness distributions and 0o angle of attack pitching program was better able to reproduce the kinematics of freely-swimming fish. This combination was likewise crucial in maximizing swimming performance and resulted in high self-propelled speeds at low costs of transport and large thrust coefficients at relatively high efficiency. Because these metrics were not all maximized together, selection of the “best” stiffness distribution will depend on actuation constraints and performance goals. These improved models enable more detailed, accurate analyses of fish-like swimming.This work was supported by an NSF Graduate Research Fellowship under grant DGE-1144152 to KNL and by ONR MURI Grant N000141410533 monitored by Dr Bob Brizzolara to GVL.2016-10-0

Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells

Type 2–associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase-1 (15LO1) is induced by the type 2 cytokine IL-13 in human airway epithelial cells (HAECs) in vitro and is increased in fresh asthmatic HAECs ex vivo. 15LO1 generates a variety of products, including 15-hydroxyeicosatetraenoic acid (15-HETE), 15-HETE-phosphatidylethanolamine (15-HETE-PE), and 13-hydroxyoctadecadienoic acid (13-HODE). In this study, we investigated the 15LO1 metabolite profile at baseline and after IL-13 treatment, as well as its influence on goblet cell differentiation in HAECs. Primary HAECs obtained from bronchial brushings of asthmatic and healthy subjects were cultured under air–liquid interface culture supplemented with arachidonic acid and linoleic acid (10 μM each) and exposed to IL-13 for 7 days. Short interfering RNA transfection and 15LO1 inhibition were applied to suppress 15LO1 expression and activity. IL-13 stimulation induced expression of 15LO1 and preferentially generated 15-HETE-PE in vitro, both of which persisted after removal of IL-13. 15LO1 inhibition (by short interfering RNA and chemical inhibitor) decreased IL-13–induced forkhead box protein A3 (FOXA3) expression and enhanced FOXA2 expression. These changes were associated with reductions in both mucin 5AC and periostin. Exogenous 15-HETE-PE stimulation (alone) recapitulated IL-13–induced FOXA3, mucin 5AC, and periostin expression. The results of this study confirm the central importance of 15LO1 and its primary product, 15-HETE-PE, for epithelial cell remodeling in HAEC