Sur quelques dédicataires et personnages des poésies de Maynard

Lassalle Jean-Louis. Sur quelques dédicataires et personnages des poésies de Maynard. In: Cahiers de la littérature du XVIIe siècle, n°1, 1979. pp. 55-63

Long-term outcome of patients hospitalized in intensive care units with central or extrapontine myelinolysis*

International audienc

Documents authentiques sur les biens de la famille d'Orléans, recueillis par Alexandre de Lassalle et Louis de La Roque

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Mouse differentiating spermatogonia can generate germinal stem cells in vivo.

International audienceIn adults, stem cells are responsible for the maintenance of many actively renewing tissues, such as haematopoietic, skin, gut and germinal tissues. These stem cells can self-renew or be committed to becoming progenitors. Stem-cell commitment is thought to be irreversible but in male and female Drosophila melanogaster, it was shown recently that differentiating germ cells can revert to functional stem cells that can restore germinal lineage. Whether progenitors are also able to generate stem cells in mammals remains unknown. Here we show that purified mouse spermatogonial progenitors committed to differentiation can generate functional germinal stem cells that can repopulate germ-cell-depleted testes when transplanted into adult mice. We found that GDNF, a key regulator of the stem-cell niche, and FGF2 are able to reprogram in vitro spermatogonial progenitors for reverse differentiation. This study supports the emerging concept that the stem-cell identity is not restricted in adults to a definite pool of cells that self-renew, but that stemness could be acquired by differentiating progenitors after tissue injury and throughout life

Eur J Radiol

To appraise the performances of an AI trained to detect and localize skeletal lesions and compare them to the routine radiological interpretation. We retrospectively collected all radiographic examinations with the associated radiologists' reports performed after a traumatic injury of the limbs and pelvis during 3 consecutive months (January to March 2017) in a private imaging group of 14 centers. Each examination was analyzed by an AI (BoneView, Gleamer) and its results were compared to those of the radiologists' reports. In case of discrepancy, the examination was reviewed by a senior skeletal radiologist to settle on the presence of fractures, dislocations, elbow effusions, and focal bone lesions (FBL). The lesion-wise sensitivity of the AI and the radiologists' reports was compared for each lesion type. This study received IRB approval (CRM-2106-177). A total of 4774 exams were included in the study. Lesion-wise sensitivity was 73.7% for the radiologists' reports vs. 98.1% for the AI (+24.4 points) for fracture detection, 63.3% vs. 89.9% (+26.6 points) for dislocation detection, 84.7% vs. 91.5% (+6.8 points) for elbow effusion detection, and 16.1% vs. 98.1% (+82 points) for FBL detection. The specificity of the radiologists' reports was always 100% whereas AI specificity was 88%, 99.1%, 99.8%, 95.6% for fractures, dislocations, elbow effusions, and FBL respectively. The NPV was measured at 99.5% for fractures, 99.8% for dislocations, and 99.9% for elbow effusions and FBL. AI has the potential to prevent diagnosis errors by detecting lesions that were initially missed in the radiologists' reports

When subsistence fishing meets conservation issues: Survey of a small fishery in a neotropical river with high biodiversity value

International audienceThe inland fisheries sector is central for subsistence in many regions worldwide. The exploitation of fish resources is expected to increase along with the growing human population, with underlying conservation issues in regions with high biodiversity value. The small fishery of the Maroni River, French Guiana, is a hotspot of biodiversity and endemism where resource depletion is suspected. We surveyed 754 boat landings in seven villages located in the upper half of the watershed, representing > 6300 fish during the study period (November 2013 - September 2014). Fishers used canoes with outboard engines almost exclusively (75 %) and fished within 32 km of their villages. Most fish were caught in trammel nets (81 %); the 20 most-landed species represented more than 87 % of catches. Depending on the village, daily catches and biomass averaged 6–14 fish and 1.7−13 kg per boat landing, respectively. Seven control sites located outside of the fishing grounds were fished to identify potential differences in catch per unit effort and fish size. Per 100 m2 of trammel net, mean catches ranged from 4 to 13 and 8–29 fish in the villages and control sites, respectively, while fish biomass ranged from 0.9 to 4 and 3.2−7 kg in villages and control sites, respectively. For all species combined, fish caught at control sites were bigger than those landed in villages. This difference was significant for nine of the most-landed species. Differences in fishing techniques and fish catches between villages illustrated the gradual disappearance of the ancestral subsistence fishing. Our results support indications that the fish community in the upper Maroni River is harvested intensively, address the issue of sustainability of the fishery there, and call attention to the need to conserve the river’s remarkable biodiversity

Observation of the Long-term Effects of Lifestyle Intervention during Balneotherapy in Metabolic Syndrome

Objective. Estimate the effect of lifestyle adjustment activities in patients with metabolic syndrome treated by prescribed balneotherapy. Methods. Observational pilot cohort study with 12-month follow-up after multidimensional lifestyle training (physical, dietary, educational) during 3-week standard stay in the spa town of Eugénie-les-Bains. Results. Of 145 eligible patients, 97 were included; 63 were followed and analysable. At inclusion all had ≥3 National cholesterol education program-Adult treatment panel III (NCEP-ATPIII) criteria defining metabolic syndrome, 76.2% were female, mean age was 61.2 years. At the end of follow-up (median:10.4 months, Inter-Quartile Range: [6.7;11.4]), 48 of these 63 patients (76.2%) no longer had metabolic syndrome (95%CI [65.7;86.7]). These 48 patients without metabolic syndrome at the end of follow-up represented 49.5% of the 97 included (95%CI [39.5;59.4]). Conclusions. Future studies of lifestyle interventions taking advantage of the spa environment can be expected to find least one third of patients free of metabolic syndrome at the end of 12-month follow-up in the intervention group