Linear growth of spiral SASI modes in core-collapse supernovae

Two-dimensional axisymmetric simulations have shown that the post-bounce accretion shock in core collapse supernovae is subject to the Spherical Accretion Shock Instability, or SASI. Recent three-dimensional simulations have revealed the existence of a non-axisymmetric mode of the SASI as well, where the postshock flow displays a spiral pattern. Here we investigate the growth of these spiral modes using two-dimensional simulations of the post-bounce accretion flow in the equatorial plane of a core-collapse supernova. By perturbing a steady-state model we are able to excite both one, two and three-armed spiral modes that grow exponentially with time, demonstrating that these are linearly unstable modes closely related to the original axisymmetric sloshing modes. By tracking the distribution of angular momentum, we show that these modes are able to efficiently separate the angular momentum of the accretion flow (which maintains a net angular momentum of zero), leading to a significant spin-up of the underlying accreting proto-neutron star.Comment: To be published in The Astrophysical Journa

Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients.

Neoantigen vaccines involving multi-peptides and poly-epitope-encoding RNA or DNA have undergone early phase clinical testing with modest reported antitumor effects [ 1]. The less-than-expected activity of these neoantigenic vaccines may correspond with the development of immune escape mechanisms. One permutation on neoantigen vaccines, which may counter or prevent these adaptive immune escape mechanisms, are 'personalized' oncolytic viruses that encode one or more tumor-specific transgenes. Herein, positive therapeutic effects for MY-NEOVAX™, personalized neoantigen-enhanced oncolytic adenoviruses, are described for two heavily pretreated end-stage patients, one with high-grade metastatic neuroendocrine carcinoma of the pancreas and the other with colorectal cancer metastatic to the brain, liver and lungs. To date, treatment benefit has exceeded 12 months without dose-limiting toxicities or related serious adverse events and with documented radiologic stabilization and improved performance status

Spatio-temporal cluster analysis of county-based human West Nile virus incidence in the continental United States

<p>Abstract</p> <p>Background</p> <p>West Nile virus (WNV) is a vector-borne illness that can severely affect human health. After introduction on the East Coast in 1999, the virus quickly spread and became established across the continental United States. However, there have been significant variations in levels of human WNV incidence spatially and temporally. In order to quantify these variations, we used Kulldorff's spatial scan statistic and Anselin's Local Moran's I statistic to uncover spatial clustering of human WNV incidence at the county level in the continental United States from 2002–2008. These two methods were applied with varying analysis thresholds in order to evaluate sensitivity of clusters identified.</p> <p>Results</p> <p>The spatial scan and Local Moran's I statistics revealed several consistent, important clusters or hot-spots with significant year-to-year variation. In 2002, before the pathogen had spread throughout the country, there were significant regional clusters in the upper Midwest and in Louisiana and Mississippi. The largest and most consistent area of clustering throughout the study period was in the Northern Great Plains region including large portions of Nebraska, South Dakota, and North Dakota, and significant sections of Colorado, Wyoming, and Montana. In 2006, a very strong cluster centered in southwest Idaho was prominent. Both the spatial scan statistic and the Local Moran's I statistic were sensitive to the choice of input parameters.</p> <p>Conclusion</p> <p>Significant spatial clustering of human WNV incidence has been demonstrated in the continental United States from 2002–2008. The two techniques were not always consistent in the location and size of clusters identified. Although there was significant inter-annual variation, consistent areas of clustering, with the most persistent and evident being in the Northern Great Plains, were demonstrated. Given the wide variety of mosquito species responsible and the environmental conditions they require, further spatio-temporal clustering analyses on a regional level is warranted.</p

Implementation of an Adaptive Controller System from Concept to Flight Test

The National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California) is conducting ongoing flight research using adaptive controller algorithms. A highly modified McDonnell-Douglas NF-15B airplane called the F-15 Intelligent Flight Control System (IFCS) was used for these algorithms. This airplane has been modified by the addition of canards and by changing the flight control systems to interface a single-string research controller processor for neural network algorithms. Research goals included demonstration of revolutionary control approaches that can efficiently optimize aircraft performance for both normal and failure conditions, and to advance neural-network-based flight control technology for new aerospace systems designs. Before the NF-15B IFCS airplane was certified for flight test, however, certain processes needed to be completed. This paper presents an overview of these processes, including a description of the initial adaptive controller concepts followed by a discussion of modeling formulation and performance testing. Upon design finalization, the next steps are: integration with the system interfaces, verification of the software, validation of the hardware to the requirements, design of failure detection, development of safety limiters to minimize the effect of erroneous neural network commands, and creation of flight test control room displays to maximize human situational awareness

Pre-Existing Superbubbles as the Sites of Gamma-Ray Bursts

According to recent models, gamma-ray bursts apparently explode in a wide variety of ambient densities ranging from ~ 10^{-3} to 30 cm^{-3}. The lowest density environments seem, at first sight, to be incompatible with bursts in or near molecular clouds or with dense stellar winds and hence with the association of gamma-ray bursts with massive stars. We argue that low ambient density regions naturally exist in areas of active star formation as the interiors of superbubbles. The evolution of the interior bubble density as a function of time for different assumptions about the evaporative or hydrodynamical mass loading of the bubble interior is discussed. We present a number of reasons why there should exist a large range of inferred afterglow ambient densities whether gamma-ray bursts arise in massive stars or some version of compact star coalescence. We predict that many gamma-ray bursts will be identified with X-ray bright regions of galaxies, corresponding to superbubbles, rather than with blue localized regions of star formation. Massive star progenitors are expected to have their own circumstellar winds. The lack of evidence for individual stellar winds associated with the progenitor stars for the cases with afterglows in especially low density environments may imply low wind densities and hence low mass loss rates combined with high velocities. If gamma-ray bursts are associated with massive stars, this combination might be expected for compact progenitors with atmospheres dominated by carbon, oxygen or heavier elements, that is, progenitors resembling Type Ic supernovae.Comment: 14 pages, no figures, submitted to The Astrophysical Journa

The development of a position-sensitive CZT detector with orthogonal co-planar anode strips

We report on the simulation, construction, and performance of prototype CdZnTe imaging detectors with orthogonal coplanar anode strips. These detectors employ a novel electrode geometry with non-collecting anode strips in one dimension and collecting anode pixels, interconnected in rows, in the orthogonal direction. These detectors retain the spectroscopic and detection efficiency advantages of single carrier (electron) sensing devices as well as the principal advantage of conventional strip detectors with orthogonal anode and cathode strips, i.e. an N×N array of imaging pixels are with only 2N electronic channels. Charge signals induced on the various electrodes of a prototype detector with 8×8 unit cells (1×1×5 mm3)are compared to the simulations. Results of position and energy resolution measurements are presented and discussed

Resolving the Formation of Protogalaxies. I. Virialization

(Abridged) Galaxies form in hierarchically assembling dark matter halos. With cosmological three dimensional adaptive mesh refinement simulations, we explore in detail the virialization of baryons in the concordance cosmology, including optically thin primordial gas cooling. We focus on early protogalaxies with virial temperatures of 10^4 K and their progenitors. Without cooling, virial heating occurs in shocks close to the virial radius for material falling in from voids. Material in dense filaments penetrates deeper to about half that radius. With cooling the virial shock position shrinks and also the filaments reach scales as small as a third the virial radius. The temperatures in protogalaxies found in adiabatic simulations decrease by a factor of two from the center and show flat entropy cores. In cooling halos the gas reaches virial equilibrium with the dark matter potential through its turbulent velocities. We observe turbulent Mach numbers ranging from one to three in the cooling cases. This turbulence is driven by the large scale merging and interestingly remains supersonic in the centers of these early galaxies even in the absence of any feedback processes. The virial theorem is shown to approximately hold over 3 orders of magnitude in length scale with the turbulent pressure prevailing over the thermal energy. The turbulent velocity distributions are Maxwellian and by far dominate the small rotation velocities associated with the total angular momentum of the galaxies. Decomposing the velocity field using the Cauchy-Stokes theorem, we show that ample amounts of vorticity are present around shocks even at the very centers of these objects.Comment: 13 pages, 6 figures. Submitted to ApJ on 8 March 2007. Revised manuscript. Comments welcom