739 research outputs found
Library Search UX report summer 2016
During Summer 2016, Imperial College London's Library Information Systems team ran a round of user experience research into the information-seeking behaviour of undergraduate and postgraduate students with a specific focus on the use of the library catalogue and discovery interface. The purpose of the work was to understand user behaviours and preferences to target development of practical improvements to the Library Search interface
QCSP on reflexive tournaments
We give a complexity dichotomy for the Quantified Constraint Satisfaction Problem QCSP(H) when H is a reflexive tournament. It is well known that reflexive tournaments can be split into a sequence of strongly connected components H1,…,Hn so that there exists an edge from every vertex of Hi to every vertex of Hj if and only if
A combinatorial approach to knot recognition
This is a report on our ongoing research on a combinatorial approach to knot
recognition, using coloring of knots by certain algebraic objects called
quandles. The aim of the paper is to summarize the mathematical theory of knot
coloring in a compact, accessible manner, and to show how to use it for
computational purposes. In particular, we address how to determine colorability
of a knot, and propose to use SAT solving to search for colorings. The
computational complexity of the problem, both in theory and in our
implementation, is discussed. In the last part, we explain how coloring can be
utilized in knot recognition
The STAR MAPS-based PiXeL detector
The PiXeL detector (PXL) for the Heavy Flavor Tracker (HFT) of the STAR
experiment at RHIC is the first application of the state-of-the-art thin
Monolithic Active Pixel Sensors (MAPS) technology in a collider environment.
Custom built pixel sensors, their readout electronics and the detector
mechanical structure are described in detail. Selected detector design aspects
and production steps are presented. The detector operations during the three
years of data taking (2014-2016) and the overall performance exceeding the
design specifications are discussed in the conclusive sections of this paper
Treatment Options for Paediatric Anaplastic Large Cell Lymphoma (ALCL): Current Standard and beyond.
Anaplastic Lymphoma Kinase (ALK)-positive Anaplastic Large Cell Lymphoma (ALCL), remains one of the most curable cancers in the paediatric setting; multi-agent chemotherapy cures approximately 65-90% of patients. Over the last two decades, major efforts have focused on improving the survival rate by intensification of combination chemotherapy regimens and employing stem cell transplantation for chemotherapy-resistant patients. More recently, several new and 'renewed' agents have offered the opportunity for a change in the paradigm for the management of both chemo-sensitive and chemo-resistant forms of ALCL. The development of ALK inhibitors following the identification of the EML4-ALK fusion gene in Non-Small Cell Lung Cancer (NSCLC) has opened new possibilities for ALK-positive ALCL. The uniform expression of CD30 on the cell surface of ALCL has given the opportunity for anti-CD30 antibody therapy. The re-evaluation of vinblastine, which has shown remarkable activity as a single agent even in the face of relapsed disease, has led to the consideration of a revised approach to frontline therapy. The advent of immune therapies such as checkpoint inhibition has provided another option for the treatment of ALCL. In fact, the number of potential new agents now presents a real challenge to the clinical community that must prioritise those thought to offer the most promise for the future. In this review, we will focus on the current status of paediatric ALCL therapy, explore how new and 'renewed' agents are re-shaping the therapeutic landscape for ALCL, and identify the strategies being employed in the next generation of clinical trials
Effect of Tuned Parameters on a LSA MCQ Answering Model
This paper presents the current state of a work in progress, whose objective
is to better understand the effects of factors that significantly influence the
performance of Latent Semantic Analysis (LSA). A difficult task, which consists
in answering (French) biology Multiple Choice Questions, is used to test the
semantic properties of the truncated singular space and to study the relative
influence of main parameters. A dedicated software has been designed to fine
tune the LSA semantic space for the Multiple Choice Questions task. With
optimal parameters, the performances of our simple model are quite surprisingly
equal or superior to those of 7th and 8th grades students. This indicates that
semantic spaces were quite good despite their low dimensions and the small
sizes of training data sets. Besides, we present an original entropy global
weighting of answers' terms of each question of the Multiple Choice Questions
which was necessary to achieve the model's success.Comment: 9 page
Transapical miniaturized ventricular assist device: Design and initial testing
BackgroundLeft ventricular assist devices are increasingly used to treat patients with advanced and otherwise refractory heart failure as bridge to transplant or destination therapy. We evaluated a new miniaturized left ventricular assist device that requires minimal surgery for implantation, potentially allowing implantation in earlier stage heart failure.MethodsHeartWare (Miami Lakes, Fla) developed transapical miniaturized ventricular assist device. Acute (n = 4), 1-week (n = 2), and 30-day (n = 4) bovine model experiments evaluated hemodynamic efficacy and biocompatibility of the device, which was implanted through small left thoracotomy with single insertion at apex of left ventricle without cardiopulmonary bypass. The device outflow cannula was positioned across the aortic valve. The international normalized ratio was maintained between 2.0 and 2.5 with warfarin. Hemodynamic, echocardiographic, fluoroscopic, hematologic, and blood chemistry measurements were evaluated.ResultsThe device was successfully implanted through the left ventricular apex in all 10 animals. The device was operated at 15,000 ± 1000 rpm (power consumption, 3.5–6.0 W). The device maintained normal end-organ perfusion with no significant hemolysis (0–30 mg/dL). There were no pump failures or device-related complications. At autopsy, no abnormalities were seen in endocardium, aortic valve leaflets, or aortic root. There was no evidence of thromboembolism or abnormalities in any peripheral end organs.ConclusionsWe successfully demonstrated feasibility of a novel intraventricular assist device that can be completely implanted through left ventricular apex. This transapical surgical approach eliminates needs for sternotomy, device pocket, cardiopulmonary bypass, ventricular coring, and construction of an outflow graft anastomosis
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