Methodical approaches to estimation of level of international competitiveness of regions

У роботі розглянуто основні підходи щодо оцінки конкурентоспроможності регіонів та світова практика регіонального бенчмаркетингу; висвітлено особливості міжнародних рейтингів конкурентоспроможності регіонів з урахуванням особливостей їхнього позиціювання на світових ринках як незалежних суб’єктів конкурентної боротьби.The basic approaches to the estimation of competitiveness of regions and world practice of regional benchmarking are highlighted; the features of the international rating of competitiveness of regions are reflected taking into account the features of their positioning on world markets as independent subjects of competitive activity

Optico-tactile method of speech rehabilitation in patients with motor aphasia: modern approach

The article deals with terminological and methodological aspects of logopedic work on overcoming speech disorders in adult patients with motor aphasia as a result of focal brain lesions and describes and analyzes the optico-tactile method in historical context.В статье рассматривается логопедическая работа по преодолению нарушений речи у больных с моторной афазией в результате очаговых поражений головного мозга

The problems of single legal field development in Russia of the early modern times (the end of the XV - the beginning of the XVII century)

The article deals with the problems associated with the peculiarities of a single legal field development in the Russian state during the epoch of the early modern era (traditionally associated in Russian historiography with the times of a single centralized state formation and development and the emergence of autocracy as a kind of early absolutism

Peculiarities of acid-base properties of peat formed in various agroclimatic zones of the Altai mountainous region

The results of the study of acid-base indicators of peat in the Altai mountainous region are presented. The natural factors that in the aggregate determine the peculiarities of the physicochemical properties of mountain peat of different agro-climatic zones of the Altai Mountains have been revealed. The variation in the acid values, total absorbed bases, adsorption capacity and the degree of saturation of raised-bog, transitional, fen peat, the number of exchangeable ions Са2+ and Mg2+ has been estimated. The interrelation among these indicators has been presented. For the first time, regression equations of the relationship between exchangeable acidity рНKCl and the degree of peat base saturation V, between total absorbed bases S and the degree of peat base saturation V have been obtained using nonlinear regression analysis. The adequacy and stability of the developed models have been verified. The calculated mean errors of approximation of regression models characterise the high accuracy of the forecast and are indicative of a good selection of models for the initial data

Human rights risks in the constitutions of the American Federal States

The article presents the results of a comparative legal analysis of the constitutions of American federal states (Argentina, Brazil, Venezuela, Canada, Mexico, and USA) with a view to identifying the norms that minimize human rights risk

Real-Time Measurement of F-Actin Remodelling during Exocytosis Using Lifeact-EGFP Transgenic Animals

F-actin remodelling is essential for a wide variety of cell processes. It is important in exocytosis, where F-actin coats fusing exocytic granules. The purpose of these F-actin coats is unknown. They may be important in stabilizing the fused granules, they may play a contractile role and promote expulsion of granule content and finally may be important in endocytosis. To elucidate these functions of F-actin remodelling requires a reliable method to visualize F-actin dynamics in living cells. The recent development of Lifeact-EGFP transgenic animals offers such an opportunity. Here, we studied the characteristics of exocytosis in pancreatic acinar cells obtained from the Lifeact-EGFP transgenic mice. We show that the time-course of agonist-evoked exocytic events and the kinetics of each single exocytic event are the same for wild type and Lifeact-EGFP transgenic animals. We conclude that Lifeact-EGFP animals are a good model to study of exocytosis and reveal that F-actin coating is dependent on the de novo synthesis of F-actin and that development of actin polymerization occurs simultaneously in all regions of the granule. Our insights using the Lifeact-EGFP mice demonstrate that F-actin coating occurs after granule fusion and is a granule-wide event

Distance education as viewed by students-defectologists

The rapidly changing reality of the modern world dictates its own rules. Out of the blue, information-technological opportunities have not just become a helping tool in the education process but, literally, a salvation in relocating education onto Internet platforms, thus actualizing the opportunities and specific features of distant education, its advantages and disadvantages, problem solutions and development trajectories. The article deals with these debatable issues in terms of the attitude to distance education of teachers and students. It contains the data obtained by the study of effectiveness of organization of the education process under the conditions of distance education carried out by the master's degree students of the Defecto-logical Faculty of Moscow State Peda-gogical University.В статье рассматривается восприятие дистанционного образования преподавателями и студентами Московского педагогического государственного университета