Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration.

Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear. The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool. By using a lineage tracing approach, we show that after injury, quiescent adult Pax7(+) cells enter the cell cycle; a subpopulation returns to quiescence to replenish the satellite cell compartment, while others contribute to muscle fiber formation. We demonstrate that Sprouty1 (Spry1), a receptor tyrosine kinase signaling inhibitor, is expressed in quiescent Pax7(+) satellite cells in uninjured muscle, downregulated in proliferating myogenic cells after injury, and reinduced as Pax7(+) cells re-enter quiescence. We show that Spry1 is required for the return to quiescence and homeostasis of the satellite cell pool during repair. Our results therefore define a role for Spry1 in adult muscle stem cell biology and tissue repair

Primary gas thermometry by means of laser-absorption spectroscopy: Determination of the Boltzmann constant

We report on a new optical implementation of primary gas thermometry based on laser absorption spectrometry in the near infrared. The method consists in retrieving the Doppler broadening from highly accurate observations of the line shape of the R(12) $\nu_{1} + 2 \nu_{2}^{\phantom{1}0} + \nu_{3}$ transition in CO$_{2}$ gas at thermodynamic equilibrium. Doppler width measurements as a function of gas temperature, ranging between the triple point of water and the gallium melting point, allowed for a spectroscopic determination of the Boltzmann constant with a relative accuracy of $\sim1.6\times10^{-4}$.Comment: Submitted to Physical Review Letter

New Relations for Gauge-Theory Amplitudes

We present an identity satisfied by the kinematic factors of diagrams describing the tree amplitudes of massless gauge theories. This identity is a kinematic analog of the Jacobi identity for color factors. Using this we find new relations between color-ordered partial amplitudes. We discuss applications to multi-loop calculations via the unitarity method. In particular, we illustrate the relations between different contributions to a two-loop four-point QCD amplitude. We also use this identity to reorganize gravity tree amplitudes diagram by diagram, offering new insight into the structure of the KLT relations between gauge and gravity tree amplitudes. This can be used to obtain novel relations similar to the KLT ones. We expect this to be helpful in higher-loop studies of the ultraviolet properties of gravity theories.Comment: 40 pages, 7 figures, RevTex, v2 minor correction

Relation between the pole and the minimally subtracted mass in dimensional regularization and dimensional reduction to three-loop order

We compute the relation between the pole quark mass and the minimally subtracted quark mass in the framework of QCD applying dimensional reduction as a regularization scheme. Special emphasis is put on the evanescent couplings and the renormalization of the epsilon-scalar mass. As a by-product we obtain the three-loop on-shell renormalization constants Zm(OS) and Z2(OS) in dimensional regularization and thus provide the first independent check of the analytical results computed several years ago.Comment: 22 page

Precise mass-dependent QED contributions to leptonic g-2 at order alpha^2 and alpha^3

Improved values for the two- and three-loop mass-dependent QED contributions to the anomalous magnetic moments of the electron, muon, and tau lepton are presented. The Standard Model prediction for the electron (g-2) is compared with its most precise recent measurement, providing a value of the fine-structure constant in agreement with a recently published determination. For the tau lepton, differences with previously published results are found and discussed. An updated value of the fine-structure constant is presented in "Note added after publication."Comment: 6 pages, 1 figure. v2: New determination of alpha presented (based on the recent electron g-2 measurement). v3: New formulae added in Sec.IIB. v4: Updated value of alpha presente

Heavy-to-heavy quark decays at NNLO

Details of a recent calculation of O(alpha_s^2) corrections to the decay b -> c,l,nu_l, taking into account the c-quark mass, are described. Construction of the expansion in the mass ratio m_c/m_b as well as the evaluation of new four-loop master integrals are presented. The same techniques are applicable to the muon decay, mu -> e,nu_mu,anti-nu_e. Analytical results are presented, for the physical cases as well as for a model with purely-vector couplings.Comment: 11 page

QCD Corrections to the Radiative Decay B -> X_s gamma

In this short review, the calculation of the next-to-next-to-leading order QCD corrections to the inclusive radiative decay B -> X_s gamma is described. I summarize the salient features of the calculational framework adopted, discuss the results obtained in the last few years, and indicate the technical tools that made the NNLO calculations possible. I conclude by comparing the current NNLO theoretical estimate for the branching ratio with the experimental measurement and by briefly discussing the size and origin of the residual theoretical uncertainty.Comment: 18 pages, 7 figures. Invited review for Modern Physics Letters