Negation in Historical West Flemish and Hollandic: an Investigation of Resilient Preverbal Markers

PhD thesisThis thesis examines the development of negation in historical West Flemish and Hollandic, focussing on resilient preverbal markers within a socio-historical framework. In doing so, my study provides a more detailed discussion of the resilient preverbal marker ne/en than previous accounts have done, as well as an explanation of why certain negative markers developed the way they did in the history of West Flemish and Hollandic. The analysis is based on an extensive, purpose-built corpus that comprises data from six centuries – from the thirteenth until the eighteenth – and two dialect regions. The dataset, which is examined using a fine-grained, century-by-century approach, thus provides diachronic breadth as well as a contrastive view of dialectal variation. In the literature, six contexts have been identified in which preverbal ne/en remains resilient: exceptives, expletives, with certain verbs, with certain adjectives or adverbs, fragment answers, and rhetorical questions. The results will be analysed on the level of morphosyntax as well as on a sociohistorical level. Firstly, my study will offer an in-depth diachronic overview of the grammaticalisation of exceptives, will analyse expletive preverbal markers as NPIs that undergo analogical change, and discuss the fossilisation of fragment answers. Secondly, I argue that urbanisation in the thirteenth to fifteenth, and the seventeenth centuries, may explain the West Flemish development of ne/en in the context of adverbs and adjectives, as well as the shift from bipartite to single niet and the loss of expletive markers in the Hollandic data. In addition, I will show that standardisation and prescriptivism can account for the attestation patterns in fifteenth-century Hollandic and eighteenth-century West Flemish. Overall, my research argues against ‘one size fits all’ explanations for the development of negation, and instead emphasises the need for a multi-faceted approach, proposing individual analyses tailored to each type of negative marker in the data.Arts and Humanities Studentship awarded by Queen Mary University of LondonSchool of Language, Linguistics and Film at Queen Mary UniversityThe Philological Society of the U

Domain of Influence analysis: implications for Data Assimilation in space weather forecasting

Solar activity, ranging from the background solar wind to energetic coronal mass ejections (CMEs), is the main driver of the conditions in the interplanetary space and in the terrestrial space environment, known as space weather. A better understanding of the Sun-Earth connection carries enormous potential to mitigate negative space weather effects with economic and social benefits. Effective space weather forecasting relies on data and models. In this paper, we discuss some of the most used space weather models, and propose suitable locations for data gathering with space weather purposes. We report on the application of \textit{Representer analysis (RA)} and \textit{Domain of Influence (DOI) analysis} to three models simulating different stages of the Sun-Earth connection: the OpenGGCM and Tsyganenko models, focusing on solar wind - magnetosphere interaction, and the PLUTO model, used to simulate CME propagation in interplanetary space. Our analysis is promising for space weather purposes for several reasons. First, we obtain quantitative information about the most useful locations of observation points, such as solar wind monitors. For example, we find that the absolute values of the DOI are extremely low in the magnetospheric plasma sheet. Since knowledge of that particular sub-system is crucial for space weather, enhanced monitoring of the region would be most beneficial. Second, we are able to better characterize the models. Although the current analysis focuses on spatial rather than temporal correlations, we find that time-independent models are less useful for Data Assimilation activities than time-dependent models. Third, we take the first steps towards the ambitious goal of identifying the most relevant heliospheric parameters for modelling CME propagation in the heliosphere, their arrival time, and their geoeffectiveness at Earth.Comment: Accepted for publication at Frontiers in Astronomy and Space Science

The Dynamic Time Warping as a Means to Assess Solar Wind Time Series

During the last decades, international attempts have been made to develop realistic space weather prediction tools aiming to forecast the conditions on the Sun and in the interplanetary environment. These efforts have led to the development of appropriate metrics in order to assess the performance of those tools. Metrics are necessary to validate models, compare different models and monitor improvements of a certain model over time. In this work, we introduce the Dynamic Time Warping (DTW) as an alternative way to evaluate the performance of models and, in particular, to quantify differences between observed and modeled solar wind time series. We present the advantages and drawbacks of this method as well as applications to WIND observations and EUHFORIA predictions at Earth. We show that DTW can warp sequences in time, aiming to align them with the minimum cost by using dynamic programming. It can be applied in two ways for the evaluation of modeled solar wind time series. The first, calculates the sequence similarity factor (SSF), a number that provides a quantification of how good the forecast is, compared to an ideal and a non-ideal prediction scenarios. The second way quantifies the time and amplitude differences between the points that are best matched between the two sequences. As a result, DTW can serve as a hybrid metric between continuous measurements (e.g., the correlation coefficient), and point-by-point comparisons. It is a promising technique for the assessment of solar wind profiles providing at once the most complete evaluation portrait of a model.Comment: Accepted for publication in The Astrophysical Journal (ApJ) in January 2022. (Comment: Section 5 has been updated as well as a number of figures, compared to the previous version. None of them affected the final results and conclusions. Also, a number of typos have been corrected

Hypothesis: hair cover can protect against invasive melanoma on the head and neck (Australia)

The anatomic distribution of cutaneous melanoma reflects people’s levels and patterns of sun exposure. While examining trends of incident invasive melanomas by site in recent decades in Australia we noted significant increases in incidence on the ears but not the face or any other site in women younger than 40 years, by 6% (95% confidence interval [CI] 2–10%) per year, and 40–59 years by 7% (95% CI 4–10%) per year. Men of the same age showed no corresponding changes in ear melanoma. However incidence rates of ear melanoma in general were fourfold higher in males than females in Australia. Further, using data from the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) Program, rates of invasive melanoma on the ear were found to be sevenfold higher in males than females in the US population in the same period. Higher rates of scalp and neck melanomas were also seen in men and women in both populations. We therefore speculated that the isolated rises of ear melanoma in younger women in Australia, and the higher overall rates of ear, scalp and neck melanoma in men compared with women, reflect differences in hair coverage. We tested the specific hypothesis that hair cover reduces sun exposure of the ears using experimental manikins and found that hair cover of the ear reduced solar ultraviolet-B exposure by 81% [SE ±8] compared with uncovered ears. We conclude that hair cover can protect against invasive melanoma on the ear and may similarly protect on the scalp and neck. When discretionary, hair may be an important additional factor to be considered for melanoma prevention

Protection against ultraviolet radiation by commercial summer clothing: need for standardised testing and labelling

BACKGROUND: The use of clothing as a means of sun protection has been recommended in recent education campaigns. Contrary to popular opinion, however, some fabrics provide insufficient ultraviolet (UV) protection. MATERIAL AND METHODS: We investigated 236 apparel textiles of the spring/summer collections 2000 and 2001. In accordance with the forthcoming European standard the UV protection factor (UPF) of the fabrics was determined spectrophotometrically. RESULTS: Seventy-eight (33%) fabrics had UPF < 15, 45 (19%) had UPF = or > 15 and < 30, and 113 (48%) had UPF = or > 30 (30+). More than 70% of the wool, polyester, and fabric blends, and only less than 30% of the cotton, linen, and viscose fabrics had UPF values of 30+. Fabrics with black, navy-blue, white, green, or beige colours provided most frequently UPF values of 30+. CONCLUSIONS: It is difficult for the sun-aware consumer to choose the 'right' garment, with a third of summer clothing providing insufficient UV protection and only half of the fabrics having UPF 30+, the UPF recommended by the European standard. Therefore, apparel summer fabrics should be measured and labelled in accordance with a standard document

Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner.

Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [ &lt;sup&gt;18&lt;/sup&gt; F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [ &lt;sup&gt;18&lt;/sup&gt; F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (&lt;10 s) which allows for whole body scans with doses as low as 3 mGy. The mouse total-body PET subsystem uses a detector architecture based on continuous crystals, coupled to SiPM arrays and a readout based in rows and columns. The PET field of view is 150 mm axial and 80 mm transaxial. The high solid-angle coverage of the sample and the use of continuous crystals achieve a sensitivity of 9% (NEMA) that can be leveraged for use of low tracer doses and/or performing rapid scans. The low-dose imaging capabilities of the total-body PET subsystem were tested with NEMA phantoms, in tumor models, a mouse bone metabolism scan and a rat heart dynamic scan. The CT imaging capabilities were tested in mice and in a low contrast phantom. The PET low-dose phantom and animal experiments provide evidence that image quality suitable for preclinical PET studies is achieved. Furthermore, CT image contrast using low dose scan settings was suitable as a reference for PET scans. Total-body mouse PET/CT studies could be completed with total doses of &lt;10 mGy

The use of germicidal ultraviolet light, vaporised hydrogen peroxide and dry heat to decontaminate face masks and filtering respirators contaminated with a SARS-CoV-2 surrogate virus

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