Semantic Web Services: State of the Art

ABSTRACT Service-oriented architectures (SOA) built on Web services were a first attempt to streamline and automate business processes in order to increase productivity but the utopian promise of uniform service interface standards, metadata, and universal service registries, in the form of the SOAP, WSDL and UDDI standards has proven elusive. Furthermore, the RPC-oriented model of those traditional Web services is not Web-friendly. Thus more and more prominent Web service providers opted to expose their services based on the REST architectural style. Nevertheless there are still problems on formal describing, finding, and orchestrating RESTful services. While there are already a number of different approaches none so far has managed to break out of its academic confines. This paper focuses on an extensive survey comparing the existing state-of-the-art technologies for semantically annotated Web services as a first step towards a proposal designed specifically for RESTful services

Lightning accidents in the Austrian alps - a 10-year retrospective nationwide analysis

Background: Lightning strikes are rare but potentially lethal. The risk for suffering a lightning strike in a mountain environment is unknown. The aim of this nationwide study was to analyse all lightning accidents in the Austrian Alps from 2005 to 2015, to assess the circumstances of the accident, the injury pattern as well as the outcome. Methods: From 2005 to 2015, data from the national Austrian Alpine Police database as well as the Clinical Information System of Innsbruck Medical University Hospital were searched for the keywords lightning injury, lightning strike, lightning as well as ICD-10 Code T75.0. Additionally, the archive data of Innsbruck Medical University Hospital was searched manually. Results: The Austrian Alpine Police database, containing 109.168 patients for the years 2005-2015, was screened for lightning accidents. Sixty-four patients had been hit by lightning in the Austrian Alps, 54 were male. Four persons died on scene;survival rate was 93.8%. Two deceased persons were hunters, who were killed by the same lightning strike. Sixty-three patients suffered a lightning strike while doing a recreational activity, mostly hiking (n = 55), a few hunting and only one doing occupational timberwork. Sixty-three patients suffered a lightning strike between June and August with nearly half (46.9%) of the accidents happening on a Saturday or Sunday, and mainly (95.3%) between 12:00 and 22:00 h. Discussion: Persons who perform recreational outdoor and occupational activities in an alpine environment during summer and after noon incur a higher risk of sustaining a lightning strike. The primary risk group includes young male mountaineers and hunters. The mortality rate was low

Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial

International audienceAbstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, placebo-controlled trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients with severe/critical COVID-19 were randomised to Baricitinib 4 mg once daily or placebo, added to standard of care. The primary endpoint was all-cause mortality within 60 days. Participants were remotely followed to day 90 for safety and patient related outcome measures. Results Two hundred ninety-nine patients were screened, 284 randomised, and 275 received study drug or placebo and were included in the modified intent-to-treat analyses (139 receiving baricitinib and 136 placebo). Median age was 60 (IQR 49–69) years, 77% were male and 35% had received at least one dose of SARS-CoV2 vaccine. There were 21 deaths at day 60 in each group, 15.1% in the baricitinib group and 15.4% in the placebo group (adjusted absolute difference and 95% CI − 0.1% [− 8·3 to 8·0]). In sensitivity analysis censoring observations after drug discontinuation or rescue therapy (tocilizumab/increased steroid dose), proportions of death were 5.8% versus 8.8% (− 3.2% [− 9.0 to 2.7]), respectively. There were 148 serious adverse events in 46 participants (33.1%) receiving baricitinib and 155 in 51 participants (37.5%) receiving placebo. In subgroup analyses, there was a potential interaction between vaccination status and treatment allocation on 60-day mortality. In a subsequent post hoc analysis there was a significant interaction between vaccination status and treatment allocation on the occurrence of serious adverse events, with more respiratory complications and severe infections in vaccinated participants treated with baricitinib. Vaccinated participants were on average 11 years older, with more comorbidities. Conclusion This clinical trial was prematurely stopped for external evidence and therefore underpowered to conclude on a potential survival benefit of baricitinib in severe/critical COVID-19. We observed a possible safety signal in vaccinated participants, who were older with more comorbidities. Although based on a post-hoc analysis, these findings warrant further investigation in other trials and real-world studies. Trial registration Bari-SolidAct is registered at NCT04891133 (registered May 18, 2021) and EUClinicalTrials.eu ( 2022-500385-99-00 )

Test of electical resistivity and current diffusion modelling on MAST and JET

Experiments have been carried out on the MAST and JET tokamaks intended to compare the electrical resistivity of the plasma with theoretical formulations. The tests consist of obtaining motional stark effect (MSE) measurements in MHD-free plasmas during plasma current ramp-up (JET and MAST), ramp-down (MAST) and in stationary state (JET and MAST). Simulations of these plasmas are then performed in which the current profile evolution is calculated according to the poloidal field diffusion equation (PFDE) with classical or neoclassical resistivity. Synthetic MSE data are produced in the simulations for direct comparison with the experimental data. It is found that the toroidal current profile evolution modelled using neoclassical resistivity did not match the experimental observations on either device during current ramp-up or ramp-down as concluded from comparison of experimental and synthetic MSE profiles. In these phases, use of neoclassical resistivity in the modelling systematically overestimates the rate of current profile evolution. During the stationary state however, the modelled toroidal current profile matched experimental observations to a high degree of accuracy on both devices using neoclassical resistivity. Whilst no solution to the mismatch in the dynamic phases of the plasma is proposed, it is suggested that some physical process other than MHD which is not captured by the simple diffusive model of current profile evolution is responsible