Particle Detection in Superfluid Helium: R&D for Low Energy Solar Neutrinos

This report presents a summary of the results from R&D conducted as a feasibility study in the Department of Physics of Brown University for detection of low energy solar neutrinos utilizing a superfluid helium target. The report outlines the results in several areas: 1) development of experimental facilities, 2) energy deposition by electrons and alphas in superfluid helium, 3) development of wafer and metallic magnetic calorimeters, 4) background studies, 5) coded apertures and conceptual design, 6) Detection of single electrons and 7) a simulation of expected performance of a full scale device. Recommendations for possible future work are also presented. A bibliography of published papers and unpublished doctoral theses is included

Arguments for a "U.S. Kamioka": SNOLab and its Implications for North American Underground Science Planning

We argue for a cost-effective, long-term North American underground science strategy based on partnership with Canada and initial construction of a modest U.S. Stage I laboratory designed to complement SNOLab. We show, by reviewing the requirements of detectors now in the R&D phase, that SNOLab and a properly designed U.S. Stage I facility would be capable of meeting the needs of North America's next wave of underground experiments. We discuss one opportunity for creating a Stage I laboratory, the Pioneer tunnel in Washington State, a site that could be developed to provide dedicated, clean, horizontal access. This unused tunnel, part of the deepest (1040 m) tunnel system in the U.S., would allow the U.S. to establish, at low risk and low cost, a laboratory at a depth (2.12 km.w.e., or kilometers of water equivalent) quite similar to that of the Japanese laboratory Kamioka (2.04 km.w.e.). We describe studies of cosmic ray attenuation important to properly locating such a laboratory, and the tunnel improvements that would be required to produce an optimal Stage I facility. We also discuss possibilities for far-future Stage II (3.62 km.w.e.) and Stage III (5.00 km.w.e.) developments at the Pioneer tunnel, should future North American needs for deep space exceed that available at SNOLab.Comment: 23 pages, 10 figures; revised version includes discusion about neutrino-factory magic baseline

Enhancement of Radiation Effect on Cancer Cells by Gold-pHLIP

Previous research has shown that gold nanoparticles can increase the effectiveness of radiation on cancer cells. Improved radiation effectiveness would allow lower radiation doses given to patients, reducing adverse effects; alternatively, it would provide more cancer killing at current radiation doses. Damage from radiation and gold nanoparticles depends in part on the Auger effect, which is very localized; thus, it is important to place the gold nanoparticles on or in the cancer cells. In this work, we use the pH-sensitive, tumor-targeting agent, pH Low-Insertion Peptide (pHLIP), to tether 1.4-nm gold nanoparticles to cancer cells. We find that the conjugation of pHLIP to gold nanoparticles increases gold uptake in cells compared with gold nanoparticles without pHLIP, with the nanoparticles distributed mostly on the cellular membranes. We further find that gold nanoparticles conjugated to pHLIP produce a statistically significant decrease in cell survival with radiation compared with cells without gold nanoparticles and cells with gold alone. In the context of our previous findings demonstrating efficient pHLIP-mediated delivery of gold nanoparticles to tumors, the obtained results serve as a foundation for further preclinical evaluation of dose enhancement

Deep Underground Science and Engineering Laboratory - Preliminary Design Report

The DUSEL Project has produced the Preliminary Design of the Deep Underground Science and Engineering Laboratory (DUSEL) at the rehabilitated former Homestake mine in South Dakota. The Facility design calls for, on the surface, two new buildings - one a visitor and education center, the other an experiment assembly hall - and multiple repurposed existing buildings. To support underground research activities, the design includes two laboratory modules and additional spaces at a level 4,850 feet underground for physics, biology, engineering, and Earth science experiments. On the same level, the design includes a Department of Energy-shepherded Large Cavity supporting the Long Baseline Neutrino Experiment. At the 7,400-feet level, the design incorporates one laboratory module and additional spaces for physics and Earth science efforts. With input from some 25 science and engineering collaborations, the Project has designed critical experimental space and infrastructure needs, including space for a suite of multidisciplinary experiments in a laboratory whose projected life span is at least 30 years. From these experiments, a critical suite of experiments is outlined, whose construction will be funded along with the facility. The Facility design permits expansion and evolution, as may be driven by future science requirements, and enables participation by other agencies. The design leverages South Dakota's substantial investment in facility infrastructure, risk retirement, and operation of its Sanford Laboratory at Homestake. The Project is planning education and outreach programs, and has initiated efforts to establish regional partnerships with underserved populations - regional American Indian and rural populations

ISSN exercise & sport nutrition review: research & recommendations

Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients