The Switch: Engaging Cultural Identity through Connection Between Communities

The purpose of this thesis is to study the relationships between people in the City of Memphis, whether they are part of the community or visitors. Each individual’s experience with the city starts somewhere, and the continued experience shapes local, regional, national, and international perceptions of the City of Memphis.Creating spaces that encourage interaction with the surrounding community can help foster positive relationships and understanding of the culture in the city. This thesis strives to create these spaces and to provide amenities to all, while embracing the values that reflect both the history of the city and the progressive movement towards a healthier, more sustainable city

Holography for the practical person

This article opens with a pedagogical discussion of holography aimed at calculating the thermodynamics and transport coefficients in condensed matter systems. Therein, we will discuss the duality of thermodynamics to classical field theory, construct the associated dual action at the field theory's boundary, and divulge the numerical techniques of the Einstein-DeTurck equations. The latter allows a numerical treatment of linear response theory in highly nontrivial gravitational backgrounds. We will use these techniques in the analysis of two major problems. In the first, we will discuss the specific implementation of the numerical methodology in the exploration of holographic lattices. Particularly, we construct generalizations of AdS-Reissner-Nordstr\"om that interpolate between those used in two previous studies --- one that reports power-law scaling for the mid-frequency regime of the optical conductivity and one that does not. We find no evidence for power-law scaling of the conductivity, thereby corroborating the previous negative result that gravitational crystals are insufficient to generate the power-law mid-infrared conductivity observed in cuprate superconductors. In the second problem, we present the full charge and energy diffusion coefficients for the Einstein-Maxwell dilaton (EMD) action for Lifshitz spacetime characterized by a dynamical critical exponent $z$. We compute the fully renormalized static Lifshitz thermodynamic potential explicitly, which confirms the forms of all thermodynamic quantities including the Bekenstein-Hawking and Smarr-like relationships. For transport, we target our analysis at finite chemical potential and include axion fields to generate momentum dissipation. Beyond analysis of the bounds, we find deviation from universal transport obtains when either the chemical potential or momentum dissipation are large relative to temperature, an echo of strong thermoelectric interactions. We also find that regardless of what is diffusing, energy or charge, the diffusion constant is independent of matter content when $z=2$. This state of affairs obtains because the diffusion equation is scale invariant when $z=2$

A simple checklist, that is all it takes: a cluster randomized controlled field trial on improving the treatment of suspected terrorists by the police

Funder: University of CambridgeAbstract: Objectives: When it comes to interviewing suspected terrorists, global evidence points to harsh interrogation procedures, despite the likelihood of false positives. How can the state maintain an effective counterterrorism policy while simultaneously protecting civil rights? Until now, the shroud of secrecy of “national security” practices has thwarted attempts by researchers to test apparatuses that engender fair interrogation procedures. The present study aims to test one approach: the use of a “procedural justice checklist” (PJ Checklist) in interviews of suspected terrorists by counterterrorism police officers in port settings. Methods: Using a clustered randomized controlled field test in a European democracy, we measure the effect of implementing Procedural Justice (PJ) Checklists in counterterrorism police settings. With 65 teams of officers randomly-assigned into treatment and control conditions, we compare post-interrogation surveys of suspects (n = 1418) on perceptions of legitimacy; obligations to obey the law; willingness to cooperate with the police; effectiveness of counterterrorism measures; distributive justice; feelings of social resistance to the state; and PJ. A series of multi-level linear, logistic, and ordered logit regression models are used to estimate the treatment effect, with Hedges’ g and odds ratios used for effect sizes. Results: When compared with control conditions, implementing a policy of PJ Checklist causes statistically significant and large enhancement in all measured dimensions, including the willingness of suspects to obey the law (g = 1.022 [0.905, 1.138]), to cooperate with the police (g = 1.118 [0.999, 1.238]), distributive justice (g = 0.993 [0.880, 1.106]), effectiveness (g = 1.077 [0.959, 1.195]), procedural justice (g = 1.044 [0.930, 1.158]), and feelings of resistance towards the state (g = − 0.370 [− 0.259, − 0.482]). Conclusions: PJ checklists offer a simple, scalable means of improving how state agents interact with terrorism suspects. The police can use what is evidently a cost-effective tool to enhance legitimacy and cooperation with the police, even in a counterterrorism environment

Coherent control of a superconducting qubit using light

Quantum science and technology promise the realization of a powerful computational resource that relies on a network of quantum processors connected with low loss and low noise communication channels capable of distributing entangled states [1,2]. While superconducting microwave qubits (3-8 GHz) operating in cryogenic environments have emerged as promising candidates for quantum processor nodes due to their strong Josephson nonlinearity and low loss [3], the information between spatially separated processor nodes will likely be carried at room temperature via telecommunication photons (200 THz) propagating in low loss optical fibers. Transduction of quantum information [4-10] between these disparate frequencies is therefore critical to leverage the advantages of each platform by interfacing quantum resources. Here, we demonstrate coherent optical control of a superconducting qubit. We achieve this by developing a microwave-optical quantum transducer that operates with up to 1.18% conversion efficiency (1.16% cooperativity) and demonstrate optically-driven Rabi oscillations (2.27 MHz) in a superconducting qubit without impacting qubit coherence times (800 ns). Finally, we discuss outlooks towards using the transducer to network quantum processor nodes

Modeling interactions between transposable elements and the plant epigenetic response: a surprising reliance on element retention

Transposable elements (TEs) compose the majority of angiosperm DNA. Plants counteract TE activity by silencing them epigenetically. One form of epigenetic silencing requires 21-22 nt small interfering RNAs that act to degrade TE mRNA and may also trigger DNA methylation. DNA methylation is reinforced by a second mechanism, the RNA-dependent DNA methylation (RdDM) pathway. RdDM relies on 24 nt small interfering RNAs and ultimately establishes TEs in a quiescent state. These host factors interact at a systems level, but there have been no system level analyses of their interactions. Here, we define a deterministic model that represents the propagation of active TEs, aspects of the host response and the accumulation of silenced TEs. We describe general properties of the model and also fit it to biological data in order to explore two questions. The first is why two overlapping pathways are maintained, given that both are likely energetically expensive. Under our model, RdDM silenced TEs effectively even when the initiation of silencing was weak. This relationship implies that only a small amount of RNAi is needed to initiate TE silencing, but reinforcement by RdDM is necessary to efficiently counter TE propagation. Second, we investigated the reliance of the host response on rates of TE deletion. The model predicted that low levels of deletion lead to few active TEs, suggesting that silencing is most efficient when methylated TEs are retained in the genome, thereby providing one explanation for the large size of plant genomes

Renal systems biology of patients with systemic inflammatory response syndrome

A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this we examined the metabolome, proteome, and transcriptome of 150 patients with critical illness, stratified by renal function. Quantification of plasma metabolites indicated greater change as renal function declined, with the greatest derangements in patients receiving chronic HD. Specifically, 6 uremic retention molecules, 17 other protein catabolites, 7 modified nucleosides, and 7 pentose phosphate sugars increased as renal function declined, consistent with decreased excretion or increased catabolism of amino acids and ribonucleotides. Similarly, the proteome showed increased levels of low-molecular weight proteins and acute phase reactants. The transcriptome revealed a broad-based decrease in mRNA levels among patients on HD. Systems integration revealed an unrecognized association between plasma RNASE1 and several RNA catabolites and modified nucleosides. Further, allantoin, N1-methyl-4-pyridone-3-carboxamide, and n-acetylaspartate were inversely correlated with the majority of significantly down-regulated genes. Thus, renal function broadly affected the plasma metabolome, proteome, and peripheral blood transcriptome during critical illness; changes not effectively mitigated by hemodialysis. These studies allude to several novel mechanisms whereby renal dysfunction contributes to critical illness