Visual contrast response functions in Parkinson's disease: evidence from electroretinograms, visually evoked potentials and psychophysics

Objectives: Visual contrast detection thresholds and suprathreshold contrast discrimination thresholds were compared to luminance and flash/pattern electroretinograms (ERG) and visually evoked potentials (VEP) in patients with Parkinson's disease (n=31), patients with multiple system atrophy (n=6), patients with progressive supranuclear palsy (n=6) and control patients without central nervous disease (n=33). Methods: The stimuli were luminance modulated full-field (flash) or horizontally oriented sinewave gratings (pattern), the latter having either a low (0.5 cycles/deg) or medium (4.0 cycles/deg) spatial frequency. Stimulus contrast ranged from 10 to 80% so that contrast response functions could be derived. Results: Contrast thresholds were higher in the patients with Parkinson's disease than in the control patients. Contrast discrimination thresholds were also somewhat elevated in patients with Parkinson's disease. Pattern ERG amplitudes were significantly reduced in patients with Parkinson's disease for the medium spatial frequency stimulus, but less for the low spatial frequency and flash stimuli. Conclusions: Our results suggest that Parkinson’s disease impairs contrast processing in the retina. VEP amplitudes did not significantly differ between the groups for the conditions tested. Patients with progressive supranuclear palsy also showed impaired contrast perception and reduced ERG amplitudes, whereas patients with multiple system atrophy were less impaired

Fractal Conductance Fluctuations in Gold--Nanowires

A detailed analysis of magneto-conductance fluctuations of quasiballistic gold-nanowires of various lengths is presented. We find that the variance $=$ when analyzed for $\Delta B$ much smaller than the correlation field $B_c$ varies according to $<(\Delta G)^2>\propto \Delta B^{\gamma}$ with $\gamma < 2$ indicating that the graph of $G$ vs. $B$ is fractal. We attribute this behavior to the existence of long-lived states arising from chaotic trajectories trapped close to regular classical orbits. We find that $\gamma$ decreases with increasing length of the wires.Comment: 5 pages, Revtex with epsf, 4 Postscript figures, final version accepted as Phys. Rev. Let

Lattice deformation at the sub-micron scale: X-ray nanobeam measurements of elastic strain in electron shuttling devices

The lattice strain induced by metallic electrodes can impair the functionality of advanced quantum devices operating with electron or hole spins. Here we investigate the deformation induced by CMOS-manufactured titanium nitride electrodes on the lattice of a buried, 10 nm-thick Si/SiGe Quantum Well by means of nanobeam Scanning X-ray Diffraction Microscopy. We were able to measure TiN electrode-induced local modulations of the strain tensor components in the range of $2 - 8 \times 10^{-4}$ with ~60 nm lateral resolution. We have evaluated that these strain fluctuations are reflected into local modulations of the potential of the conduction band minimum larger than 2 meV, which is close to the orbital energy of an electrostatic quantum dot. We observe that the sign of the strain modulations at a given depth of the quantum well layer depends on the lateral dimensions of the electrodes. Since our work explores the impact of device geometry on the strain-induced energy landscape, it enables further optimization of the design of scaled CMOS-processed quantum devices.Comment: 16 pages, 6 figure

Regulatory Model for AAL

Proceedings of: 6th International Conference on Soft Computing Models in Industrial and Environmental Applications (SOCO 2011). Salamanca, April 6-8, 2011Abstract: In this work, authors define a set of principles that should be contained in context-aware applications (including biometric sensors) to accomplish the legal aspect in Europe and USA. Paper presents the necessity to consider legal aspect, related with pri-vacy or human rights, into the development of the incipient context based services. Clearly, context based services and Ambient Intelligence (and the most promising work area in Europe that is Ambient Assisted Living, ALL) needs a great effort in research new identification procedures.Publicad

Search for Θ+(1540)\Theta^+(1540) pentaquark in high statistics measurement of γp→Kˉ0K+n\gamma p \to \bar K^0 K^+ n at CLAS

The exclusive reaction $\gamma p \to \bar K^0 K^+ n$ was studied in the photon energy range between 1.6-3.8 GeV searching for evidence of the exotic baryon $\Theta^+(1540)\to nK^+$. The decay to $nK^+$ requires the assignment of strangeness $S=+1$ to any observed resonance. Data were collected with the CLAS detector at the Thomas Jefferson National Accelerator Facility corresponding to an integrated luminosity of 70 $pb^{-1}$. No evidence for the $\Theta^+$ pentaquark was found. Upper limits were set on the production cross section as function of center-of-mass angle and $nK^+$ mass. The 95% CL upper limit on the total cross section for a narrow resonance at 1540 MeV was found to be 0.8 nb.Comment: Submitted to Physical Review Letter

Light Vector Mesons in the Nuclear Medium

The light vector mesons ($\rho$, $\omega$, and $\phi$) were produced in deuterium, carbon, titanium, and iron targets in a search for possible in-medium modifications to the properties of the $\rho$ meson at normal nuclear densities and zero temperature. The vector mesons were detected with the CEBAF Large Acceptance Spectrometer (CLAS) via their decays to $e^{+}e^{-}$. The rare leptonic decay was chosen to reduce final-state interactions. A combinatorial background was subtracted from the invariant mass spectra using a well-established event-mixing technique. The $\rho$ meson mass spectrum was extracted after the $\omega$ and $\phi$ signals were removed in a nearly model-independent way. Comparisons were made between the $\rho$ mass spectra from the heavy targets ($A > 2$) with the mass spectrum extracted from the deuterium target. With respect to the $\rho$-meson mass, we obtain a small shift compatible with zero. Also, we measure widths consistent with standard nuclear many-body effects such as collisional broadening and Fermi motion.Comment: 15 pages, 18 figures, 3 table

Electroproduction of ϕ(1020)\phi(1020) mesons at 1.4≤Q2≤1.4\leq Q^2\leq GeV2^2 measured with the CLAS spectrometer

Electroproduction of exclusive $\phi$ vector mesons has been studied with the CLAS detector in the kinematical range $1.4\leq Q^2\leq 3.8$ GeV$^{2}$, $0.0\leq t^{\prime}\leq 3.6$ GeV$^{2}$, and $2.0\leq W\leq 3.0$ GeV. The scaling exponent for the total cross section as $1/(Q^2+M_{\phi}^2)^n$ was determined to be $n=2.49\pm 0.33$. The slope of the four-momentum transfer $t'$ distribution is $b_{\phi}=0.98 \pm 0.17$ GeV$^{-2}$. Under the assumption of s-channel helicity conservation (SCHC), we determine the ratio of longitudinal to transverse cross sections to be $R=0.86 \pm 0.24$. A 2-gluon exchange model is able to reproduce the main features of the data.Comment: Phys Rev C, 15 pages, 18 figure

Measurement of the Polarized Structure Function σLT′\sigma_{LT^\prime} for p(e⃗,e′π+)np(\vec{e},e'\pi^+)n in the Δ(1232)\Delta(1232) Resonance Region

The polarized longitudinal-transverse structure function $\sigma_{LT^\prime}$ has been measured using the $p(\vec e,e'\pi^+)n$ reaction in the $\Delta(1232)$ resonance region at $Q^2=0.40$ and 0.65 GeV$^2$. No previous $\sigma_{LT^\prime}$ data exist for this reaction channel. The kinematically complete experiment was performed at Jefferson Lab with the CEBAF Large Acceptance Spectrometer (CLAS) using longitudinally polarized electrons at an energy of 1.515 GeV. A partial wave analysis of the data shows generally better agreement with recent phenomenological models of pion electroproduction compared to the previously measured $\pi^0 p$ channel. A fit to both $\pi^0 p$ and $\pi^+ n$ channels using a unitary isobar model suggests the unitarized Born terms provide a consistent description of the non-resonant background. The $t$-channel pion pole term is important in the $\pi^0 p$ channel through a rescattering correction, which could be model-dependent.Comment: 6 pages, LaTex, 5 eps figures: Submitted to PRC/Brief Reports v2: Updated referenc

Quantitative 3-Dimensional Imaging of Murine Neointimal and Atherosclerotic Lesions by Optical Projection Tomography

Traditional methods for the analysis of vascular lesion formation are labour intensive to perform - restricting study to ‘snapshots’ within each vessel. This study was undertaken to determine the suitability of optical projection tomographic (OPT) imaging for the 3-dimensional representation and quantification of intimal lesions in mouse arteries. = 0.85), confirming both the accuracy of this methodology and its non-destructive nature. It was also possible to record volumetric measurements of lesion and lumen and these were highly reproducible between scans (coefficient of variation = 5.36%, 11.39% and 4.79% for wire- and ligation-injury and atherosclerosis, respectively).These data demonstrate the eminent suitability of OPT for imaging of atherosclerotic and neointimal lesion formation, providing a much needed means for the routine 3-dimensional analysis of vascular morphology in studies of this type