Electronic ground states of Fe2+_2^+ and Co2+_2^+ as determined by x-ray absorption and x-ray magnetic circular dichroism spectroscopy

The $^6\Pi$ electronic ground state of the Co$_2^+$ diatomic molecular cation has been assigned experimentally by x-ray absorption and x-ray magnetic circular dichroism spectroscopy in a cryogenic ion trap. Three candidates, $^6\Phi$, $^8\Phi$, and $^8\Gamma$, for the electronic ground state of Fe$_2^+$ have been identified. These states carry sizable orbital angular momenta that disagree with theoretical predictions from multireference configuration interaction and density functional theory. Our results show that the ground states of neutral and cationic diatomic molecules of $3d$ transition elements cannot generally be assumed to be connected by a one-electron process

Genomic insights into the causes of type 2 diabetes.

Genome-wide association studies have implicated around 250 genomic regions in predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for several of these regions. Understanding of the underlying mechanisms, including the interplay between β-cell failure, insulin sensitivity, appetite regulation, and adipose storage has been facilitated by the integration of multidimensional data for diabetes-related intermediate phenotypes, detailed genomic annotations, functional experiments, and now multiomic molecular features. Studies in diverse ethnic groups and examples from population isolates have shown the value and need for a broad genomic approach to this global disease. Transethnic discovery efforts and large-scale biobanks in diverse populations and ancestries could help to address some of the Eurocentric bias. Despite rapid progress in the discovery of the highly polygenic architecture of type 2 diabetes, dominated by common alleles with small, cumulative effects on disease risk, these insights have been of little clinical use in terms of disease prediction or prevention, and have made only small contributions to subtype classification or stratified approaches to treatment. Successful development of academia-industry partnerships for exome or genome sequencing in large biobanks could help to deliver economies of scale, with implications for the future of genomics-focused research

Direct Observation of High-Spin States in Manganese Dimer and Trimer Cations by X-ray Magnetic Circular Dichroism Spectroscopy in an Ion Trap

The electronic structure and magnetic moments of free Mn$_2^+$ and Mn$_3^+$ are characterized by $2p$ x-ray absorption and x-ray magnetic circular dichroism spectroscopy in a cryogenic ion trap that is coupled to a synchrotron radiation beamline. Our results show directly that localized magnetic moments of 5 $\mu_B$ are created by $3d^5 (^6\mathrm{S})$ states at each ionic core, which are coupled in parallel to form molecular high-spin states via indirect exchange that is mediated in both cases by a delocalized valence electron in a singly-occupied $4s$ derived orbital with an unpaired spin. This leads to total magnetic moments of 11 $\mu_B$ for Mn$_2^+$ and 16 $\mu_B$ for Mn$_3^+$, with no contribution of orbital angular momentum

The internal Josephson effect in a Fermi gas near a Feshbach resonance

We consider a two-component system of Fermi atoms and molecular bosons in the vicinity of a Feshbash resonance. We derive an effective action for the system, which has a term describing coherent tunneling of the molecular bosons into Cooper pairs and vice versa. In the equilibrium state, global phase coherence may be destroyed by thermal or quantum phase fluctuations. In the non-equilibrium regime, the system may show an internal AC Josephson effect leading to real time oscillations in the number of molecular bosons.Comment: 5 pages, 2 figure

Phase Modulated Thermal Conductance of Josephson Weak Links

We present a theory for quasiparticle heat transport through superconducting weak links. The thermal conductance depends on the phase difference ($\phi$) of the superconducting leads. Branch conversion processes, low-energy Andreev bound states near the contact and the suppression of the local density of states near the gap edge are related to phase-sensitive transport processes. Theoretical results for the influence of junction transparency, temperature and disorder, on the phase modulation of the conductance are reported. For high-transmission weak links, $D\to 1$, the formation of an Andreev bound state at $\epsilon_{\text{\tiny b}}=\Delta\cos(\phi/2)$ leads to suppression of the density of states for the continuum excitations that transport heat, and thus, to a reduction in the conductance for $\phi\simeq\pi$. For low-transmission ($D\ll 1$) barriers resonant scattering at energies $\epsilon\simeq(1+D/2)\Delta$ leads to an increase in the thermal conductance as $T$ drops below $T_c$ (for phase differences near $\phi=\pi$).Comment: 4 pages, 3 figures Expanded discussion of boundary conditions for Ricatti amplitude

Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches.

PURPOSE OF THE REVIEW: Causality has been demonstrated for few of the many putative risk factors for type 2 diabetes (T2D) emerging from observational epidemiology. Genetic approaches are increasingly being used to infer causality, and in this review, we discuss how genetic discoveries have shaped our understanding of the causal role of factors associated with T2D. RECENT FINDINGS: Genetic discoveries have led to the identification of novel potential aetiological factors of T2D, including the protective role of peripheral fat storage capacity and specific metabolic pathways, such as the branched-chain amino acid breakdown. Consideration of specific genetic mechanisms contributing to overall lipid levels has suggested that distinct physiological processes influencing lipid levels may influence diabetes risk differentially. Genetic approaches have also been used to investigate the role of T2D and related metabolic traits as causal risk factors for other disease outcomes, such as cancer, but comprehensive studies are lacking. Genome-wide association studies of T2D and metabolic traits coupled with high-throughput molecular phenotyping and in-depth characterisation and follow-up of individual loci have provided better understanding of aetiological factors contributing to T2D

Coordination-driven magnetic-to-nonmagnetic transition in manganese doped silicon clusters

The interaction of a single manganese impurity with silicon is analyzed in a combined experimental and theoretical study of the electronic, magnetic, and structural properties of manganese-doped silicon clusters. The structural transition from exohedral to endohedral doping coincides with a quenching of high-spin states. For all geometric structures investigated, we find a similar dependence of the magnetic moment on the manganese coordination number and nearest neighbor distance. This observation can be generalized to manganese point defects in bulk silicon, whose magnetic moments fall within the observed magnetic-to-nonmagnetic transition, and which therefore react very sensitively to changes in the local geometry. The results indicate that high spin states in manganese-doped silicon could be stabilized by an appropriate lattice expansion

Postural control and head stability during natural gaze behaviour in 6- to 12-year-old children

We investigated how the influence of natural exploratory gaze behaviour on postural control develops from childhood into adulthood. In a cross-sectional design, we compared four age groups: 6-, 9-, 12-year-olds and young adults. Two experimental trials were performed: quiet stance with a fixed gaze (fixed) and quiet stance with natural exploratory gaze behaviour (exploratory). The latter was elicited by having participants watch an animated short film on a large screen in front of them. 3D head rotations in space and centre of pressure (COP) excursions on the ground plane were measured. Across conditions, both head rotation and COP displacement decreased with increasing age. Head movement was greater in the exploratory condition in all age groups. In all children—but not in adults—COP displacement was markedly greater in the exploratory condition. Bivariate correlations across groups showed highly significant positive correlations between COP displacement in ML direction and head rotation in yaw, roll, and pitch in both conditions. The regularity of COP displacements did not show a clear developmental trend, which indicates that COP dynamics were qualitatively similar across age groups. Together, the results suggest that the contribution of head movement to eye-head saccades decreases with age and that head instability—in part resulting from such gaze-related head movements—is an important limiting factor in children's postural control. The lack of head stabilisation might particularly affect children in everyday activities in which both postural control and visual exploration are require

Indizierte Prävention von Alkoholabhängigkeit und –missbrauch:Motivational Interviewing versus Feedback only ; eine randomisierte kontrollierte Studie

Die randomisierte kontrollierte Studie untersucht, ob die isolierten oder kombinierten Kurzinterventionen Motivational Interviewing und Feedback erfolgreich den riskanten Alkoholkonsum oder die daraus resultierenden Konsequenzen reduzieren können. Die Überlegenheit der Interventionen gegenüber einer Kontrollgruppe wurde unter strenger Kontrolle der Manualtreue überprüft. Die Teilnehmer (N = 98) absolvierten nach einem standardisiertem Screening ein umfangreiches Assessment und nahmen an einer der folgenden Interventionen teil: (1) Feedback, (2) MI, (3) Feedback + MI, (4) Kontrollgruppe. Die Follow-up-Untersuchungen zeigten nach 4 und 8 Wochen eine signifikante Reduktion des Alkoholkonsums in allen Gruppen (N = 90), nicht aber eine Reduktion der Konsequenzen des Konsums. Gründe für die mangelnde Überlegenheit der Kurzinterventionen gegenüber der Kontrollgruppe können im Screening, dem umfangreichen Assessment, der Stichprobe oder den Interventionen selber liegen