Measurements in the Turbulent Boundary Layer at Constant Pressure in Subsonic and Supersonic Flow. Part 2: Laser-Doppler Velocity Measurements

A description of both the mean and the fluctuating components of the flow, and of the Reynolds stress as observed using a dual forward scattering laser-Doppler velocimeter is presented. A detailed description of the instrument and of the data analysis techniques were included in order to fully document the data. A detailed comparison was made between the laser-Doppler results and those presented in Part 1, and an assessment was made of the ability of the laser-Doppler velocimeter to measure the details of the flows involved

The moduli space of hypersurfaces whose singular locus has high dimension

Let $k$ be an algebraically closed field and let $b$ and $n$ be integers with $n\geq 3$ and $1\leq b \leq n-1.$ Consider the moduli space $X$ of hypersurfaces in $\mathbb{P}^n_k$ of fixed degree $l$ whose singular locus is at least $b$-dimensional. We prove that for large $l$, $X$ has a unique irreducible component of maximal dimension, consisting of the hypersurfaces singular along a linear $b$-dimensional subspace of $\mathbb{P}^n$. The proof will involve a probabilistic counting argument over finite fields.Comment: Final version, including the incorporation of all comments by the refere

Quantum critical behaviour of the plateau-insulator transition in the quantum Hall regime

High-field magnetotransport experiments provide an excellent tool to investigate the plateau-insulator phase transition in the integral quantum Hall effect. Here we review recent low-temperature high-field magnetotransport studies carried out on several InGaAs/InP heterostructures and an InGaAs/GaAs quantum well. We find that the longitudinal resistivity $\rho_{xx}$ near the critical filling factor $\nu_{c}$ ~ 0.5 follows the universal scaling law $\rho_{xx}(\nu, T) \propto exp[-\Delta \nu/(T/T_{0})^{\kappa}]$, where $\Delta \nu =\nu -\nu_{c}$. The critical exponent $\kappa$ equals $0.56 \pm 0.02$, which indicates that the plateau-insulator transition falls in a non-Fermi liquid universality class.Comment: 8 pages, accepted for publication in Proceedings of the Yamada Conference LX on Research in High Magnetic Fields (August 16-19, 2006, Sendai

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care. Here, we compared The Cancer Genome Atlas (TCGA) and the Genomics Evidence Neoplasia Information Exchange (GENIE) breast cancer genomic datasets (array and next generation sequencing (NGS) data) in detecting genomic alterations in clinically relevant genes. We performed an in silico analysis to determine the concordance in the frequencies of actionable mutations and copy number alterations/aberrations (CNAs) in the two most common breast cancer histologies, invasive lobular and invasive ductal carcinoma. We found that targeted sequencing identified a larger number of mutational hotspots and clinically significant amplifications that would have been missed by WES and SNP arrays in many actionable genes such as PIK3CA, EGFR, AKT3, FGFR1, ERBB2, ERBB3 and ESR1. The striking differences between the number of mutational hotspots and CNAs generated from these platforms highlight a number of factors that should be considered in the interpretation of array and NGS-based genomic data for precision medicine. Targeted panel sequencing was preferable to WES to define the full spectrum of somatic mutations present in a tumor

Ferroelectric properties of charge-ordered alpha-(BEDT-TTF)2I3

A detailed investigation of the out-of-plane electrical properties of charge-ordered alpha-(BEDT-TTF)2I3 provides clear evidence for ferroelectricity. Similar to multiferroic alpha-(BEDT-TTF)2Cu[N(CN)2]Cl, the polar order in this material is ascribed to the occurrence of bond- and site-centered charge order. Dielectric response typical for relaxor ferroelectricity is found deep in the charge-ordered state. We suggest an explanation in terms of the existence of polar and nonpolar stacks of the organic molecules in this material, preventing long-range ferroelectricity. The results are discussed in relation to the formation or absence of electronic polar order in related charge-transfer salts.Comment: 8 pages, 4 figures. Revised version as accepted for publication in Phys. Rev.

X-ray fluoresced high-Z (up to Z = 82) K-x-rays produced by LiNbO3 and LiTaO3 pyroelectric crystal electron accelerators

High-energy bremsstrahlung and K X-rays were used to produce nearly background-free K X-ray spectra of up to 87 keV (Pb) via X-ray fluorescence. The fluorescing radiation was produced by electron accelerators, consisting of heated and cooled cylindrical LiTaO3 and LiNbO3 crystals at mTorr pressures. The newly discovered process of gas amplification whereby the ambient gas pressure is optimized to maximize the electron energy was used to produce energetic electrons which when incident on a W/Bi target gave rise to a radiation field consisting of high-energy bremsstrahlung as well as W and Bi K X-rays. These photons were used to fluoresce Ta and Pb K X-rays.Comment: 6 pages, 6 figures, PD