25,112 research outputs found
Measurements in the Turbulent Boundary Layer at Constant Pressure in Subsonic and Supersonic Flow. Part 2: Laser-Doppler Velocity Measurements
A description of both the mean and the fluctuating components of the flow, and of the Reynolds stress as observed using a dual forward scattering laser-Doppler velocimeter is presented. A detailed description of the instrument and of the data analysis techniques were included in order to fully document the data. A detailed comparison was made between the laser-Doppler results and those presented in Part 1, and an assessment was made of the ability of the laser-Doppler velocimeter to measure the details of the flows involved
The moduli space of hypersurfaces whose singular locus has high dimension
Let be an algebraically closed field and let and be integers with
and Consider the moduli space of
hypersurfaces in of fixed degree whose singular locus is
at least -dimensional. We prove that for large , has a unique
irreducible component of maximal dimension, consisting of the hypersurfaces
singular along a linear -dimensional subspace of . The proof
will involve a probabilistic counting argument over finite fields.Comment: Final version, including the incorporation of all comments by the
refere
Quantum critical behaviour of the plateau-insulator transition in the quantum Hall regime
High-field magnetotransport experiments provide an excellent tool to
investigate the plateau-insulator phase transition in the integral quantum Hall
effect. Here we review recent low-temperature high-field magnetotransport
studies carried out on several InGaAs/InP heterostructures and an InGaAs/GaAs
quantum well. We find that the longitudinal resistivity near the
critical filling factor ~ 0.5 follows the universal scaling law
, where . The critical exponent equals ,
which indicates that the plateau-insulator transition falls in a non-Fermi
liquid universality class.Comment: 8 pages, accepted for publication in Proceedings of the Yamada
Conference LX on Research in High Magnetic Fields (August 16-19, 2006,
Sendai
Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.
Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care. Here, we compared The Cancer Genome Atlas (TCGA) and the Genomics Evidence Neoplasia Information Exchange (GENIE) breast cancer genomic datasets (array and next generation sequencing (NGS) data) in detecting genomic alterations in clinically relevant genes. We performed an in silico analysis to determine the concordance in the frequencies of actionable mutations and copy number alterations/aberrations (CNAs) in the two most common breast cancer histologies, invasive lobular and invasive ductal carcinoma. We found that targeted sequencing identified a larger number of mutational hotspots and clinically significant amplifications that would have been missed by WES and SNP arrays in many actionable genes such as PIK3CA, EGFR, AKT3, FGFR1, ERBB2, ERBB3 and ESR1. The striking differences between the number of mutational hotspots and CNAs generated from these platforms highlight a number of factors that should be considered in the interpretation of array and NGS-based genomic data for precision medicine. Targeted panel sequencing was preferable to WES to define the full spectrum of somatic mutations present in a tumor
Ferroelectric properties of charge-ordered alpha-(BEDT-TTF)2I3
A detailed investigation of the out-of-plane electrical properties of
charge-ordered alpha-(BEDT-TTF)2I3 provides clear evidence for
ferroelectricity. Similar to multiferroic alpha-(BEDT-TTF)2Cu[N(CN)2]Cl, the
polar order in this material is ascribed to the occurrence of bond- and
site-centered charge order. Dielectric response typical for relaxor
ferroelectricity is found deep in the charge-ordered state. We suggest an
explanation in terms of the existence of polar and nonpolar stacks of the
organic molecules in this material, preventing long-range ferroelectricity. The
results are discussed in relation to the formation or absence of electronic
polar order in related charge-transfer salts.Comment: 8 pages, 4 figures. Revised version as accepted for publication in
Phys. Rev.
X-ray fluoresced high-Z (up to Z = 82) K-x-rays produced by LiNbO3 and LiTaO3 pyroelectric crystal electron accelerators
High-energy bremsstrahlung and K X-rays were used to produce nearly
background-free K X-ray spectra of up to 87 keV (Pb) via X-ray fluorescence.
The fluorescing radiation was produced by electron accelerators, consisting of
heated and cooled cylindrical LiTaO3 and LiNbO3 crystals at mTorr pressures.
The newly discovered process of gas amplification whereby the ambient gas
pressure is optimized to maximize the electron energy was used to produce
energetic electrons which when incident on a W/Bi target gave rise to a
radiation field consisting of high-energy bremsstrahlung as well as W and Bi K
X-rays. These photons were used to fluoresce Ta and Pb K X-rays.Comment: 6 pages, 6 figures, PD
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