A Physical Limit to the Magnetic Fields of T Tauri Stars

Recent estimates of magnetic field strengths in T Tauri stars yield values $B=1$--$4\,{\rm kG}$. In this paper, I present an upper limit to the photospheric values of $B$ by computing the equipartition values for different surface gravities and effective temperatures. The values of $B$ derived from the observations exceed this limit, and I examine the possible causes for this discrepancy

Milne-Eddington inversion of the Fe I line pair at 630~nm

The iron lines at 630.15 and 630.25 nm are often used to determine the physical conditions of the solar photosphere. A common approach is to invert them simultaneously under the Milne-Eddington approximation. The same thermodynamic parameters are employed for the two lines, except for their opacities, which are assumed to have a constant ratio. We aim at investigating the validity of this assumption, since the two lines are not exactly the same. We use magnetohydrodynamic simulations of the quiet Sun to examine the behavior of the ME thermodynamic parameters and their influence on the retrieval of vector magnetic fields and flow velocities. Our analysis shows that the two lines can be coupled and inverted simultaneously using the same thermodynamic parameters and a constant opacity ratio. The inversion of two lines is significantly more accurate than single-line inversions because of the larger number of observables.Comment: Accepted for publication in Astronomy and Astrophysics (Research Note

Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets

The activation of human platelets by α-thrombin is mediated at least in part by cleavage of protease-activated G-protein-coupled receptors, PAR-1 and PAR-4. Platelet glycoprotein Ibα also has a high affinity binding site for α-thrombin, and this interaction contributes to platelet activation through a still unknown mechanism. In the present study the hypothesis that GpIbα may contribute to platelet activation by modulating the hydrolysis of PAR-1 on the platelet membrane was investigated. Gel-filtered platelets from normal individuals were stimulated by α-thrombin, and the kinetics of PAR-1 hydrolysis by enzyme was followed with flow cytometry using an anti-PAR-1 monoclonal antibody (SPAN 12) that recognizes only intact PAR-1 molecules. This strategy allowed measurement of the apparentk cat/K m value for thrombin hydrolysis of PAR-1 on intact platelets, which was equal to 1.5 ± 0.1 × 107 m −1sec−1. The hydrolysis rate of PAR-1 by thrombin was measured under conditions in which thrombin binding to GpIb was inhibited by different strategies, with the following results. 1) Elimination of GpIbα on platelet membranes by mocarhagin treatment reduced the k cat/K m value by about 6-fold. 2) A monoclonal anti-GpIb antibody reduced the apparent k cat/K m value by about 5-fold. 3) An oligonucleotide DNA aptamer, HD22, which binds to the thrombin heparin-binding site (HBS) and inhibits thrombin interaction with GpIbα, reduced the apparentk cat/K m value by about 5-fold. 4) Displacement of α-thrombin from the binding site on GpIb using PPACK-thrombin reduced the apparentk cat/K m value by about 5-fold, and 5) mutation at the HBS of thrombin (R98A) caused a 5-fold reduction of the apparentk cat/K m value of PAR-1 hydrolysis. Altogether these results show that thrombin interaction with GpIb enhances the specificity of thrombin cleavage of PAR-1 on intact platelets, suggesting that GpIb may function as a “cofactor” for PAR-1 activation by thrombin

The Immune Response to Tumors as a Tool toward Immunotherapy

Until recently cancer medical therapy was limited to chemotherapy that could not differentiate cancer cells from normal cells. More recently with the remarkable mushroom of immunology, newer tools became available, resulting in the novel possibility to attack cancer with the specificity of the immune system. Herein we will review some of the recent achievement of immunotherapy in such aggressive cancers as melanoma, prostatic cancer, colorectal carcinoma, and hematologic malignancies. Immunotherapy of tumors has developed several techniques: immune cell transfer, vaccines, immunobiological molecules such as monoclonal antibodies that improve the immune responses to tumors. This can be achieved by blocking pathways limiting the immune response, such as CTLA-4 or Tregs. Immunotherapy may also use cytokines especially proinflammatory cytokines to enhance the activity of cytotoxic T cells (CTLs) derived from tumor infiltrating lymphocytes (TILs). The role of newly discovered cytokines remains to be investigated. Alternatively, an other mechanism consists in enhancing the expression of TAAs on tumor cells. Finally, monoclonal antibodies may be used to target oncogenes

Time-Dependent Behavior of Linear Polarization in Unresolved Photospheres, With Applications for The Hanle Effect

Aims: This paper extends previous studies in modeling time varying linear polarization due to axisymmetric magnetic fields in rotating stars. We use the Hanle effect to predict variations in net line polarization, and use geometric arguments to generalize these results to linear polarization due to other mechanisms. Methods: Building on the work of Lopez Ariste et al., we use simple analytic models of rotating stars that are symmetric except for an axisymmetric magnetic field to predict the polarization lightcurve due to the Hanle effect. We highlight the effects for the variable line polarization as a function of viewing inclination and field axis obliquity. Finally, we use geometric arguments to generalize our results to linear polarization from the weak transverse Zeeman effect. Results: We derive analytic expressions to demonstrate that the variable polarization lightcurve for an oblique magnetic rotator is symmetric. This holds for any axisymmetric field distribution and arbitrary viewing inclination to the rotation axis. Conclusions: For the situation under consideration, the amplitude of the polarization variation is set by the Hanle effect, but the shape of the variation in polarization with phase depends largely on geometrical projection effects. Our work generalizes the applicability of results described in Lopez Ariste et al., inasmuch as the assumptions of a spherical star and an axisymmetric field are true, and provides a strategy for separating the effects of perspective from the Hanle effect itself for interpreting polarimetric lightcurves.Comment: 6 pages; 4 figures. Includes an extra figure found only in this preprint versio

Analytical maximum likelihood estimation of stellar magnetic fields

The polarised spectrum of stellar radiation encodes valuable information on the conditions of stellar atmospheres and the magnetic fields that permeate them. In this paper, we give explicit expressions to estimate the magnetic field vector and its associated error from the observed Stokes parameters. We study the solar case where specific intensities are observed and then the stellar case, where we receive the polarised flux. In this second case, we concentrate on the explicit expression for the case of a slow rotator with a dipolar magnetic field geometry. Moreover, we also give explicit formulae to retrieve the magnetic field vector from the LSD profiles without assuming mean values for the LSD artificial spectral line. The formulae have been obtained assuming that the spectral lines can be described in the weak field regime and using a maximum likelihood approach. The errors are recovered by means of the hermitian matrix. The bias of the estimators are analysed in depth.Comment: accepted for publication in MNRA