Analyse der ästhetischen contemplation (malerei und plastik)

Vita.Inaug.-diss.--Zürich.Mode of access: Internet

[Materials on Stefan George].

This collection contains a manuscript by Edith Landmann "An die deutschen Juden, die zum geheimen Deutschland hielten;" letter regarding the Landmann manuscript; letter from Gerhard Jarecki to Frans Kobler regarding Jews in Palestine and a section regarding Stefan George.ClippingsPoet, 1868-1933The original German language inventory is available in the folder.Processed for digitizationRetitledSent for digitizationReturned from digitizationLinked to online manifestationdigitize

Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression

CD14 contributes to LPS signaling in leukocytes through formation of toll-like receptor 4/CD14 receptor complexes; however, a specific role for endogenous cell-surface CD14 in endothelial cells is unclear. We have found that suppression of glutathione peroxidase-1 (GPx-1) in human microvascular endothelial cells increases CD14 gene expression compared to untreated or siControl (siCtrl)-treated conditions. Following LPS treatment, GPx-1 deficiency augmented LPS-induced intracellular reactive oxygen species accumulation, CD14 expression, and intercellular adhesion molecule-1 (ICAM-1) mRNA and protein expression compared to LPS-treated control cells. GPx-1 deficiency also transiently augmented LPS-induced vascular cell adhesion molecule-1 (VCAM-1) expression. Adenoviral overexpression of GPx-1 significantly diminished LPS-mediated responses in adhesion molecule expression. Consistent with these findings, LPS responses were also greater in endothelial cells derived from GPx-1-knockout mice, whereas adhesion molecule expression was decreased in cells from GPx-1-overexpressing transgenic mice. Knockdown of CD14 attenuated LPS-mediated up-regulation of ICAM-1 and VCAM-1 mRNA and protein, and it mitigated the effects of GPx-1 deficiency on LPS-induced adhesion molecule expression. Taken together, these data suggest that GPx-1 modulates the endothelial cell response to LPS, in part, by altering CD14-mediated effects.—Lubos, E., Mahoney, C. E., Leopold, J. A., Zhang, Y.-Y., Loscalzo, J., Handy, D. E. Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression

Mosquito species collected across the study sites in Tana-River and Isiolo counties, Kenya.

<p>Mosquito species collected across the study sites in Tana-River and Isiolo counties, Kenya.</p

Map of vector sampling sites in Isiolo and Tana-River counties, Kenya.

<p>Map of vector sampling sites in Isiolo and Tana-River counties, Kenya.</p