Toolkit for exploring ethical aspects of digital social and affective touch interactions

In this hands-on demonstration, people are invited to use a newly developed toolkit to scrutinize their attitude and preferences towards digital social and affective touch interactions

Toolkit for exploring ethical aspects of digital social and affective touch interactions

In this hands-on demonstration, people are invited to use a newly developed toolkit to scrutinize their attitude and preferences towards digital social and affective touch interactions

Toolkit for exploring ethical aspects of digital social and affective touch interactions

In this hands-on demonstration, people are invited to use a newly developed toolkit to scrutinize their attitude and preferences towards digital social and affective touch interactions

The artist as host

In this publication you will find:Hosting the hybrid cityThis is a text in which Hermen Maat and Karen Lancel provide insights into the meaning of the word ‘role’ and into the position of the role of the ‘host’ in their own artistic practice. Their artistic research into this role was the starting point for both research modulesThe artist as host: on theories and interactive networked mushrooms.In the second text Hermen Maat clarifies how he translated this concept into two teaching modules. He explains how in one module the focus of the search was interesting examples of artist’s roles, and how in the other module technical issues shed a different light on the relationship between artist and audience.Student researchAfter this, you will find the work of students, introduced by Hermen Maat. Contributions from the theme class:Anna Weyer, Germany; Chan Lai Kuen, Malaysia; Katrina Jongsma, Canada; Rosemarie Pringle, Germany; Angie Daniels, South Africa/Germany; Niya Konstantinova, Bulgaria; Gothards Prieditis, Latvia; Ruben Jager,Netherlands. Contributions from the interactive media class: Helena Van Zuylen, Netherlands; Suzanne Vellema, Netherlands; Vanina Tsvetkova, Bulgaria; Jorine Homan, Netherlands; Cindy Wegner, Germany; Lotte Middendorp, Netherlands; Sander Bos, Netherlands; Chan Lai Kuen, Malaysia; Iris Leenknegt, Netherlands.The urgency of the role of the host In the afterword Anke Coumans, professor of the research group Image in Context, talks about the importance of this research for the work of the Centre of Applied Research and Innovation Art & Society into the new roles of artists and designers in society

CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

International audienceIn addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardiovascular diseases and type-2 diabetes development, two pathologies associated with impaired hepatic lipid metabolism. Although p16 was recently shown to control hepatic glucose homeostasis, it is unknown whether p16 also controls hepatic lipid metabolism. Using a combination of in vivo and in vitro approaches, we found that p16 modulates fasting-induced hepatic fatty acid oxidation (FAO) and lipid droplet accumulation. In primary hepatocytes, p16-deficiency was associated with elevated expression of genes involved in fatty acid catabolism. These transcriptional changes led to increased FAO and were associated with enhanced activation of PPARα through a mechanism requiring the catalytic AMPKα2 subunit and SIRT1, two known activators of PPARα. By contrast, p16 overexpression was associated with triglyceride accumulation and increased lipid droplet numbers in vitro, and decreased ketogenesis and hepatic mitochondrial activity in vivo. Finally, gene expression analysis of liver samples from obese patients revealed a negative correlation between CDKN2A expression and PPARA and its target genes. Our findings demonstrate that p16 represses hepatic lipid catabolism during fasting and may thus participate in the preservation of metabolic flexibility

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

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