862 research outputs found
Why material slow light does not improve cavity-enhanced atom detection
We discuss the prospects for enhancing absorption and scattering of light
from a weakly coupled atom in a high-finesse optical cavity by adding a medium
with large, positive group index of refraction. The slow-light effect is known
to narrow the cavity transmission spectrum and increase the photon lifetime,
but the quality factor of the cavity may not be increased in a metrologically
useful sense. Specifically, detection of the weakly coupled atom through either
cavity ringdown measurements or the Purcell effect fails to improve with the
addition of material slow light. A single-atom model of the dispersive medium
helps elucidate why this is the case.Comment: 11 pages, 4 figures; QuTiP python file included. This version:
changed title and added several references; results are unchanged. Accepted
for open access publication in a special issue of Journal of Modern Optics in
memory of Prof Danny Segal. Publisher's version available at
http://dx.doi.org/10.1080/09500340.2017.138451
Early handling and repeated cross-fostering have opposite effect on mouse emotionality
Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders. Animal models of postnatal stress have been developed in rodents to explore molecular mechanisms responsible for the observed short and long lasting neurobiological effects of such manipulations. The main aim of this study was to compare the behavioral and hormonal phenotype of young and adult animals exposed to different postnatal treatments. Outbred mice were exposed to (i) the classical Handling protocol (H: 15 min-day of separation from the mother from day 1 to 14 of life) or to (ii) a Repeated Cross-Fostering protocol (RCF: adoption of litters from day 1 to 4 of life by different dams). Handled mice received more maternal care in infancy and showed the already described reduced emotionality at adulthood. Repeated cross fostered animals did not differ for maternal care received, but showed enhanced sensitivity to separation from the mother in infancy and altered respiratory response to 6% CO2 in breathing air in comparison with controls. Abnormal respiratory responses to hypercapnia are commonly found among humans with panic disorders (PD), and point to RCF-induced instability of the early environment as a valid developmental model for PD. The comparisons between short-and long-term effects of postnatal handling vs. RCF indicate that different types of early adversities are associated with different behavioral profiles, and evoke psychopathologies that can be distinguished according to the neurobiological systems disrupted by early-life manipulation
Antimicrobial activity of biogenically produced spherical Se-nanomaterials embedded in organic material against Pseudomonas aeruginosa and Staphylococcus aureus strains on hydroxyapatite-coated surfaces
In an effort to prevent the formation of pathogenic biofilms on hydroxyapatite (HA)-based clinical devices and surfaces, we present a study evaluating the antimicrobial efficacy of Spherical biogenic Se-Nanostructures Embedded in Organic material (Bio Se-NEMO-S) produced by Bacillus mycoides SelTE01 in comparison with two different chemical selenium nanoparticle (SeNP) classes. These nanomaterials have been studied as potential antimicrobials for eradication of established HA-grown biofilms, for preventing biofilm formation on HA-coated surfaces and for inhibition of planktonic cell growth of Pseudomonas aeruginosa NCTC 12934 and Staphylococcus aureus ATCC 25923. Bio Se-NEMO resulted more efficacious than those chemically produced in all tested scenarios. Bio Se-NEMO produced by B. mycoides SelTE01 after 6 or 24 h of Na 2 SeO 3 exposure show the same effective antibiofilm activity towards both P. aeruginosa and S. aureus strains at 0.078 mg ml â1 (Bio Se-NEMO 6 ) and 0.3125 mg ml â1 (Bio Se-NEMO 24 ). Meanwhile, chemically synthesized SeNPs at the highest tested concentration (2.5 mg ml â1 ) have moderate antimicrobial activity. The confocal laser scanning micrographs demonstrate that the majority of the P. aeruginosa and S. aureus cells exposed to biogenic SeNPs within the biofilm are killed or eradicated. Bio Se-NEMO therefore displayed good antimicrobial activity towards HA-grown biofilms and planktonic cells, becoming possible candidates as new antimicrobials
Biomolecular composition of capping layer and stability of biogenic selenium nanoparticles synthesized by five bacterial species
Biogenic metal/metalloid nanoparticles of microbial origin retain a functional biomolecular capping layer that confers structural stability. Little is known about the composition of such capping material. In this study, selenium nanoparticles (SeNPs) synthesized by five different bacterial strains underwent comparative analysis with newly proposed protocols for quantifying the concentration of carbohydrates, proteins and lipids present in capping layers. SeNPs were therefore treated with two different detergents to remove portions of the surrounding caps in order to assess the resulting effects. Capping material quantification was carried out along with the measure of parameters such as hydrodynamic diameter, polydispersity and surface charge. SeNPs from the five strains showed differences in their distinct biomolecule ratios. On the other hand, structural changes in the nanoparticles induced by detergents did not correlate with the amounts of capping matrix removed. Thus, the present investigation suggests a hypothesis to describe capping layer composition of the bacterial SeNPs: some biomolecules are bound more strongly than others to the core metalloid matrix, so that the diverse capping layer components differentially contribute to the overall structural characteristics of the nanoparticles. Furthermore, the application of the approach here in combining quantification of cap-associated biomolecules with the measurement of structural integrity-related parameters can give the biogenic nanomaterial field useful information to construct a data bank on biogenically synthesized nanostructures
Parameterized Compilation Lower Bounds for Restricted CNF-formulas
We show unconditional parameterized lower bounds in the area of knowledge
compilation, more specifically on the size of circuits in decomposable negation
normal form (DNNF) that encode CNF-formulas restricted by several graph width
measures. In particular, we show that
- there are CNF formulas of size and modular incidence treewidth
whose smallest DNNF-encoding has size , and
- there are CNF formulas of size and incidence neighborhood diversity
whose smallest DNNF-encoding has size .
These results complement recent upper bounds for compiling CNF into DNNF and
strengthen---quantitatively and qualitatively---known conditional low\-er
bounds for cliquewidth. Moreover, they show that, unlike for many graph
problems, the parameters considered here behave significantly differently from
treewidth
Introducing a relocation service for one-way carsharing with a first-in first-served policy
In one-way carsharing users are allowed to return cars to locations different from those where they were picked up. but directional imbalances in their requests result in the accumulation of unnecessary cars in some areas, whereas other areas face car shortages. To correct tins situation, we investigate the introduction of a new relocation service by a staff equipped with foldable motorcycles: They are driven to move to unused cars and are put inside cars, which are driven by the staff where they are requested. Although the relocation staff size can be determined by a state-of-The-Art model, it tends to overestimate the manpower maximizing the overall system profitability in a first-in first served policy. Tins paper presents an optimization model correcting this drawback. Tins model can be used to investigate how different manpower levels change the percentage of satisfied user bookings and determine the most profitable staff size configuration
Charge density waves enhance the electronic noise of manganites
The transport and noise properties of Pr_{0.7}Ca_{0.3}MnO_{3} epitaxial thin
films in the temperature range from room temperature to 160 K are reported. It
is shown that both the broadband 1/f noise properties and the dependence of
resistance on electric field are consistent with the idea of a collective
electrical transport, as in the classical model of sliding charge density
waves. On the other hand, the observations cannot be reconciled with standard
models of charge ordering and charge melting. Methodologically, it is proposed
to consider noise-spectra analysis as a unique tool for the identification of
the transport mechanism in such highly correlated systems. On the basis of the
results, the electrical transport is envisaged as one of the most effective
ways to understand the nature of the insulating, charge-modulated ground states
in manganites.Comment: 6 two-column pages, 5 figure
On the ability of perfluorohexane sulfonate (PFHxS) bioaccumulation by two Pseudomonas sp. strains isolated from PFASâcontaminated environmental matrices
PFASs (perfluoroalkyl and polyfluoroalkyl substances) are highly fluorinated, aliphatic, synthetic compounds with high thermal and chemical stability as well as unique amphiphilic properties which make them ingredients in a range of industrial processes. PFASs have attracted consideration due to their persistence, toxicity and bioaccumulation tendency in the environment. Recently, attention has begun to be addressed to shorterâchain PFASs, such as perfluorohexane sulfonate [PFHxS], apparently less toxic to and more easily eliminated from lab animals. However, shortâchain PFASs represent endâproducts from the transformation of fluorotelomers whose biotic breakdown reactions have not been identified to date. This means that such emergent pollutants will tend to accumulate and persist in ecosystems. Since we are just learning about the interaction between shortâchain PFASs and microorganisms, this study reports on the response to PFHxS of two Pseudomonas sp. strains isolated from environmental matrices contaminated by PFASs. The PFHxS bioaccumulation potential of these strains was unveiled by exploiting different physiological conditions as either axenic or mixed cultures under alkanothrofic settings. Moreover, electron microscopy revealed nonorthodox features of the bacterial cells, as a consequence of the stress caused by both organic solvents and PFHxS in the culturing substrate
On the Ability of Perfluorohexane Sulfonate (PFHxS) Bioaccumulation by Two Pseudomonas sp. Strains Isolated from PFAS-Contaminated Environmental Matrices
PFASs (perfluoroalkyl and polyfluoroalkyl substances) are highly fluorinated, aliphatic, synthetic compounds with high thermal and chemical stability as well as unique amphiphilic properties which make them ingredients in a range of industrial processes. PFASs have attracted consideration due to their persistence, toxicity and bioaccumulation tendency in the environment. Recently, attention has begun to be addressed to shorter-chain PFASs, such as perfluorohexane sulfonate [PFHxS], apparently less toxic to and more easily eliminated from lab animals. However, short-chain PFASs represent end-products from the transformation of fluorotelomers whose biotic breakdown reactions have not been identified to date. This means that such emergent pollutants will tend to accumulate and persist in ecosystems. Since we are just learning about the interaction between short-chain PFASs and microorganisms, this study reports on the response to PFHxS of two Pseudomonas sp. strains isolated from environmental matrices contaminated by PFASs. The PFHxS bioaccumulation potential of these strains was unveiled by exploiting different physiological conditions as either axenic or mixed cultures under alkanothrofic settings. Moreover, electron microscopy revealed nonorthodox features of the bacterial cells, as a consequence of the stress caused by both organic solvents and PFHxS in the culturing substrate
Expanding the expressive power of Monadic Second-Order logic on restricted graph classes
We combine integer linear programming and recent advances in Monadic
Second-Order model checking to obtain two new algorithmic meta-theorems for
graphs of bounded vertex-cover. The first shows that cardMSO1, an extension of
the well-known Monadic Second-Order logic by the addition of cardinality
constraints, can be solved in FPT time parameterized by vertex cover. The
second meta-theorem shows that the MSO partitioning problems introduced by Rao
can also be solved in FPT time with the same parameter. The significance of our
contribution stems from the fact that these formalisms can describe problems
which are W[1]-hard and even NP-hard on graphs of bounded tree-width.
Additionally, our algorithms have only an elementary dependence on the
parameter and formula. We also show that both results are easily extended from
vertex cover to neighborhood diversity.Comment: Accepted for IWOCA 201
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