24 research outputs found
Pomiar parametrów torów telewizyjnych metodą linii kontrolnej. Część II. Przegląd Zagadnień Łączności, 1967, nr 10 (73)
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Substitution of Cytosine with Guanylurea Decreases the Stability of i-Motif DNA
Both 5-aza-2′-deoxycytidine (decitabine) and its primary breakdown product, 2′-deoxyriboguanylurea (GuaUre-dR), have been shown to act as mutagens and epimutagens that cause replication stress and alter both DNA methylation and gene expression patterns. As cytosine analogues, both are expected to be preferentially incorporated into regions of GC skew where runs of cytosine residues are sequestered on one strand and guanine residues on the other. Given that such regions have been identified as sites with the potential for effects on gene expression and replication stress linked to formation of alternative DNA secondary structures, it is of interest to determine the influence that these base analogues might have on the stability of structures of this kind. Here we report that incorporation of GuaUre-dR into an i-motif-forming sequence decreases both the thermal and pH stability of an i-motif despite the apparent ability of GuaUre-dR to base pair with cytosine
Prognostic Significance of Wnt-1, β-catenin and E-cadherin Expression in Advanced Colorectal Carcinoma
Wnt/β-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, β-catenin and Wnt-1 proteins in colorectal tumors. Expression of β-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, β-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear β-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized in colon or rectum were independent unfavorable prognostic factors. These findings support the hypothesis that Wnt/β-catenin pathway plays an important role in advanced colorectal carcinoma
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
Theoretical determination of the vibrational raman optical activity signatures of helical polypropylene chains
Solvent effects on Raman Optical Activity spectra calculated using the Polarizable Continuum Model
The integral equation formulation of the polarizable continuum model (IEFPCM) has been extended to the
calculation of solvent effects on vibrational Raman optical activity spectra. Gauge-origin independence of
the differential scattering intensities of right and left circularly polarized light is ensured through the use of
London atomic orbitals. Density functional theory (DFT) calculations have been carried out for bromochlorofluoromethane,
methyloxirane, and epichlorhydrin. The results indicate that solvent effects on the ROA
differential scattering intensities can be substantial, and vary in sign and magnitude for different vibrational
modes. It is demonstrated that both direct and indirect effects are important in determining the total solvent
effects on the ROA differential scattering intensities. Local field effects are shown to be in general small,
whereas electronic nonequilibrium solvation has a profound effect on the calculated solvent effects compared
to an equilibrium solvation model. For molecules with several conformations, the changes in the relative
stability of the different conformers also lead to noticeable changes in the ROA spectra
[Intravenous clomipramine for depressive disorders].
51 patients with depressive episode (40--recurrent depressive disorder, 11--bipolar affective disorder) were treated by the clomipramine intravenous infusions. The number of infusions varied from 5 to 21 (mostly 10-16). The median of maximal dose was 150 mg. There were significant clinical improvement measured by CGI. The therapy was well tolerated