Experimental quantum key distribution over highly noisy channels

Error filtration is a method for encoding the quantum state of a single particle into a higher dimensional Hilbert space in such a way that it becomes less sensitive to phase noise. We experimentally demonstrate this method by distributing a secret key over an optical fiber whose noise level otherwise precludes secure quantum key distribution. By filtering out the phase noise, a bit error rate of 15.3% +/- 0.1%, which is beyond the security limit, can be reduced to 10.6% +/- 0.1%, thereby guaranteeing the cryptographic security.Comment: 4 pages, 2 figure

Provably Secure Experimental Quantum Bit-String Generation

Coin tossing is a cryptographic task in which two parties who do not trust each other aim to generate a common random bit. Using classical communication this is impossible, but non trivial coin tossing is possible using quantum communication. Here we consider the case when the parties do not want to toss a single coin, but many. This is called bit string generation. We report the experimental generation of strings of coins which are provably more random than achievable using classical communication. The experiment is based on the ``plug and play'' scheme developed for quantum cryptography, and therefore well suited for long distance quantum communication.Comment: 4 pages, 3 figures. Submitted to Phys. Rev. Lett. A complete security analysis for the experiment is given in quant-ph/040812

Layer-Resolved Ultrafast XUV Measurement of Hole Transport in a Ni-TiO2-Si Photoanode

Metal-oxide-semiconductor junctions are central to most electronic and optoelectronic devices. Here, the element-specificity of broadband extreme ultraviolet (XUV) ultrafast pulses is used to measure the charge transport and recombination kinetics in each layer of a Ni-TiO2-Si junction. After photoexcitation of silicon, holes are inferred to transport from Si to Ni ballistically in ~100 fs, resulting in spectral shifts in the Ni M2,3 XUV edge that are characteristic of holes and the absence of holes initially in TiO2. Meanwhile, the electrons are observed to remain on Si. After picoseconds, the transient hole population on Ni is observed to back-diffuse through the TiO2, shifting the Ti spectrum to higher oxidation state, followed by electron-hole recombination at the Si-TiO2 interface and in the Si bulk. Electrical properties, such as the hole diffusion constant in TiO2 and the initial hole mobility in Si, are fit from these transient spectra and match well with values reported previously

Thermal phase diagrams of columnar liquid crystals

In order to understand the possible sequence of transitions from the disordered columnar phase to the helical phase in hexa(hexylthio)triphenylene (HHTT), we study a three-dimensional planar model with octupolar interactions inscribed on a triangular lattice of columns. We obtain thermal phase diagrams using a mean-field approximation and Monte Carlo simulations. These two approaches give similar results, namely, in the quasi one-dimensional regime, as the temperature is lowered, the columns order with a linear polarization, whereas helical phases develop at lower temperatures. The helicity patterns of the helical phases are determined by the exact nature of the frustration in the system, itself related to the octupolar nature of the molecules.Comment: 12 pages, 9 figures, ReVTe

Astrophysical Neutrino Event Rates and Sensitivity for Neutrino Telescopes

Spectacular processes in astrophysical sites produce high-energy cosmic rays which are further accelerated by Fermi-shocks into a power-law spectrum. These, in passing through radiation fields and matter, produce neutrinos. Neutrino telescopes are designed with large detection volumes to observe such astrophysical sources. A large volume is necessary because the fluxes and cross-sections are small. We estimate various telescopes' sensitivities and expected event rates from astrophysical sources of high-energy neutrinos. We find that an ideal detector of km^2 incident area can be sensitive to a flux of neutrinos integrated over energy from 10^5 and 10^{7} GeV as low as 1.3 * 10^(-8) * E^(-2) (GeV/cm^2 s sr) which is three times smaller than the Waxman-Bachall conservative upper limit on potential neutrino flux. A real detector will have degraded performance. Detection from known point sources is possible but unlikely unless there is prior knowledge of the source location and neutrino arrival time.Comment: Section added +modification

From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions

©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.doi:10.1371/journal.pcbi.1000341DNA–protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA–protein interactions is a challenging problem. Here, we present a novel computational approach for predicting DNA-binding protein residues and DNA–protein interaction modes without knowing its specific DNA target sequence. Given the structure of a DNA-binding protein, the method first generates an ensemble of complex structures obtained by rigid-body docking with a nonspecific canonical B-DNA. Representative models are subsequently selected through clustering and ranking by their DNA–protein interfacial energy. Analysis of these encounter complex models suggests that the recognition sites for specific DNA binding are usually favorable interaction sites for the nonspecific DNA probe and that nonspecific DNA–protein interaction modes exhibit some similarity to specific DNA–protein binding modes. Although the method requires as input the knowledge that the protein binds DNA, in benchmark tests, it achieves better performance in identifying DNA-binding sites than three previously established methods, which are based on sophisticated machine-learning techniques. We further apply our method to protein structures predicted through modeling and demonstrate that our method performs satisfactorily on protein models whose root-mean-square Ca deviation from native is up to 5 Å from their native structures. This study provides valuable structural insights into how a specific DNA-binding protein interacts with a nonspecific DNA sequence. The similarity between the specific DNA–protein interaction mode and nonspecific interaction modes may reflect an important sampling step in search of its specific DNA targets by a DNA-binding protein

The JAX Synteny Browser for mouse-human comparative genomics.

Visualizing regions of conserved synteny between two genomes is supported by numerous software applications. However, none of the current applications allow researchers to select genome features to display or highlight in blocks of synteny based on the annotated biological properties of the features (e.g., type, function, and/or phenotype association). To address this usability gap, we developed an interactive web-based conserved synteny browser, The Jackson Laboratory (JAX) Synteny Browser. The browser allows researchers to highlight or selectively display genome features in the reference and/or the comparison genome according to the biological attributes of the features. Although the current implementation for the browser is limited to the reference genomes for the laboratory mouse and human, the software platform is intentionally genome agnostic. The JAX Synteny Browser software can be deployed for any two genomes where genome coordinates for syntenic blocks are defined and for which biological attributes of the features in one or both genomes are available in widely used standard bioinformatics file formats. The JAX Synteny Browser is available at: http://syntenybrowser.jax.org/. The code base is available from GitHub: https://github.com/TheJacksonLaboratory/syntenybrowser and is distributed under the Creative Commons Attribution license (CC BY)

GRB 081203A: Swift UVOT captures the earliest ultraviolet spectrum of a gamma-ray burst

We present the earliest ultraviolet (UV) spectrum of a gamma-ray burst (GRB) as observed with the Swift Ultra-Violet/Optical Telescope (UVOT). The GRB 081203A spectrum was observed for 50 s with the UV-grism starting 251 s after the Swift-Burst-Alert-Telescope (BAT) trigger. During this time, the GRB was ≈13.4 mag (u filter) and was still rising to its peak optical brightness. In the UV-grism spectrum, we find a damped Lyα line, Lyβ and the Lyman continuum break at a redshift z= 2.05 ± 0.01. A model fit to the Lyman absorption implies a gas column density of log NH i= 22.0 ± 0.1 cm−2, which is typical of GRB host galaxies with damped Lyα absorbers. This observation of GRB 081203A demonstrates that for brighter GRBs (v≈ 14 mag) with moderate redshift (0.5 < z < 3.5) the UVOT is able to provide redshifts, and probe for damped Lyα absorbers within 4–6 min from the time of the Swift-BAT trigger

Is chronic kidney disease associated with diabetic retinopathy in Asian adults?

Background: Diabetic nephropathy (DN) is commonly associated with diabetic retinopathy (DR). Few studies have demonstrated that chronic kidney disease (CKD) is associated with DR. However, it is not clear if CKD in the absence of albuminuria is associated with DR. Methods: We included 301 participants with diabetes (Chinese, Malay and Indian ethnicity aged ≥24 years who participated in the Singapore Prospective Study Program (2003-2007). Retinal photographs taken from both eyes were graded for DR using the modified Airlie House Classification. We examined the association of CKD defined by low estimated glomerular filtration rate (eGFR) (&lt;60mL/min per 1.73m2, n=54), and albuminuria (urinary albumin-to-creatinine ratio ≥30, n = 116) with any-DR (n=99) in logistic regression models. We replicated this analysis in another independent population-based sample of Malay adults (n=265) with similar methodology in Singapore. Results: 41% of those with low-eGFR had normoalbuminuria. In separate models, while albuminuria was significantly associated with any-DR, low-eGFR was not significantly associated with any-DR. In a model combining both markers, compared to the referent group (normal-eGFR+normoalbuminuria), the odds ratio (OR) (95% confidence interval [CI]) of any-DR were: 2.33 (1.27-4.27) for normal-eGFR+albuminuria, 1.38 (0.49-3.91) for low-eGFR + normoalbuminuria, and 2.64 (1.05-6.63) for low-eGFR+albuminuria. Similar findings for any-DR were observed in the replication cohort of Malay persons (3.56 [1.49-8.54] for normal-eGFR+albuminuria, 1.69 (0.52-5.55) for low-eGFR+normoalbuminuria, 4.34 [1.68-11.24] for low-eGFR+albuminuria.Conclusion: We demonstrated that CKD is associated with DR only in the presence of albuminuria suggesting that CKD is more likely related to diabetes in the presence of albuminuria.</p