Risk Factors for Childhood Problem Behavior: Studies in Twins and Triplets

Boomsma, D.I. [Promotor]Middeldorp, C.M. [Copromotor]Vink, J.M. [Copromotor

Fluctuation formula for nonreversible dynamics in the thermostated Lorentz gas

We investigate numerically the validity of the Gallavotti-Cohen fluctuation formula in the two and three dimensional periodic Lorentz gas subjected to constant electric and magnetic fields and thermostated by the Gaussian isokinetic thermostat. The magnetic field breaks the time reversal symmetry, and by choosing its orientation with respect to the lattice one can have either a generalized reversing symmetry or no reversibility at all. Our results indicate that the scaling property described by the fluctuation formula may be approximately valid for large fluctuations even in the absence of reversibility.Comment: 6 pages, 6 figure

A high resolution imaging detector for TeV gamma-ray astronomy

Details are presented of an atmospheric Cherenkov telescope for use in very high energy gamma-ray astronomy which consists of a cluster of 109 close-packed photomultiplier tubes at the focus of a 10 meter optical reflector. The images of the Cherenkov flashes generated both by gamma-ray and charged cosmic-ray events are digitized and recorded. Subsequent off-line analysis of the images improves the significance of the signal to noise ratio by a factor of 10 compared with non-imaging techniques

Microsatellite instability and defects in mismatch repair proteins: a new aetiology for Sertoli cell‐only syndrome

Microsatellite instability is characteristic of certain types of cancer, and is present in rodents lacking specific DNA mismatch repair proteins. These azoospermic mice exhibit spermatogenic defects similar to some human testicular failure patients. Therefore, we hypothesized that microsatellite instability due to deficiencies in mismatch repair genes might be an unrecognized aetiology of human testicular failure. Because these azoospermic patients are candidates for testicular sperm extraction and ICSI, transmission of mismatch repair defects to the offspring is possible. Seven microsatellite loci were analysed for instability in specimens from 41 testicular failure patients and 20 controls. Blood and testicular DNA were extracted from patient and control specimens, and amplified by PCR targeting seven microsatellite loci. DNA fragment length was analysed with an ABI Prism 310 Genotyping Machine and GeneScan software. Immunohistochemistry was performed on paraffinized testis biopsy sections and cultured testicular fibroblasts from each patient to determine if expression of the mismatch repair proteins hMSH2 and hMLH1 was normal in both somatic and germline cells. Results demonstrate that microsatellite instability and DNA mismatch repair protein defects are present in some azoospermic men, predominantly in Sertoli cell‐only patients (P < 0.01 and P < 0.05 respectively). This provides evidence of a previously unrecognized aetiology of testicular failure that may be associated with cancer predispositio

A summary of the methodology for the seismic stratigraphic interpretation for the 'GlaciStore' bid to IODP

This report summarises the methodology followed for the seismic interpretation of sedimentary strata that are the overburden sequence and the Palaeogene strata that are prospective CO2 storage formations, in the UK Central North Sea. The interpretation of selected 2D and 3D seismic reflection, well and borehole data in the UK North and Central North Sea is targeted to inform the preparation of the ‘GlaciStore’ proposal for scientific drilling submitted to the International Ocean Discovery Programme (IODP). Drilling sites proposed to IODP lie within the UK and Norwegian sectors of the North Sea. The methodology is described for the interpretation of seismic data for proposed sites within UK waters. The seismic interpretation was undertaken in collaboration with Norwegian members of the GlaciStore consortium. The seismic interpretation was divided into two teams according to depth, into ‘shallower and ‘deeper’ seismic interpretation activities, appropriate to the fields of expertise and experience of the interpreters. The ‘shallower seismic’ interpreters considered strata of latest Neogene and Quaternary age which were deposited during major glacial and interglacial cycles. The ‘deeper seismic’ interpreters considered slightly older strata of Mid Eocene to Quaternary in age. Seven potential UK drill sites were selected to address the scientific objectives in the proposal. 2D and 3D seismic, well, borehole and bathymetry data were used to map buried and open tunnel valleys and to identify any evidence for the presence of shallow gas in the ‘shallower seismic’ interpretation at each drill site. Only sites without any indication of shallow gas features were considered as these pose a serious hazard for drilling. 2D and 3D seismic and well datasets and existing interpretations were collated for the ‘deeper seismic’ interpretation. The hydrocarbon exploration well log data, which were found to be of variable quality, were used to identify and map a number of stratigraphical surfaces of Cenozoic age, and included Quaternary strata, around the grid of seismic lines. Maps from some of the key stratigraphical surfaces are presented, selected to inform the drilling proposal. A plot of acoustic velocity data was prepared to inform future conversion of the seismic interpretation to true vertical depth. Future work, based on the seismic interpretation undertaken to underpin the drilling proposal, is identified. Features observed within the ‘shallower’ and ‘deeper’ seismic interpretations that warrant further investigation are: a chaotic zone within the Quaternary sequence; prograding units within the Eocene Horda Formation; basin centre sandstone bodies as prospective CO2 storage strata within the Horda Formation; systematic mapping of cross-cutting, buried tunnel valleys in the Quaternary sequence from 3D seismic data

Doppler-Free Spectroscopy of Weak Transitions: An Analytical Model Applied to Formaldehyde

Experimental observation of Doppler-free signals for weak transitions can be greatly facilitated by an estimate for their expected amplitudes. We derive an analytical model which allows the Doppler-free amplitude to be estimated for small Doppler-free signals. Application of this model to formaldehyde allows the amplitude of experimentally observed Doppler-free signals to be reproduced to within the experimental error.Comment: 7 pages, 7 figures, 1 table, v2: many small improvements + corrected line assignmen

Detection of noncyling cows by heatmount decectors and ultrasound before treatment with progesterone

Our objective was to determine accuracy of identifying anovulatory lactating dairy cows before the application of a timed AI protocol [with or without progesterone supplementation via a controlled internal drug release (CIDR) insert and 2 different timings of AI] by using heatmount detectors and a single ovarian ultrasound examination. At 6 Midwest locations, 1,072 cows were enrolled in a Presynch protocol (2 injections of prostaglandin F2α(PGF2α) 14 days apart) with the second injection administered 14 days before initiating the Ovsynch protocol (injection of gonadotropin releasing hormone (GnRH) 7 days before and 48 hours after PGF2αinjection, with timed AI at 0 or 24 hours after the second GnRH injection). Heatmount detectors were applied to cows at the time of the first Presynch injection, assessed 14 days later at the second Presynch injection and again at initiation of the Ovsynch protocol, and ovaries were examined for presence of a visible corpus luteum (CL) by ultrasound before initiation of treatment. Treatments were assigned to cows based on presence or absence of a visible CL: 1) anovulatory (no CL + CIDR insert for 7 d); 2) anovulatory (no CL + no CIDR); and 3) cycling (CL present). Further, every other cow in the 3 treatments was assigned to be inseminated concurrent with the second GnRH injection of Ovsynch (0 hour) or 24 hours later. Pregnancy was diagnosed at 33 and 61 days after the second GnRH injection. Heatmount detectors and a single ultrasound examination both underestimated proportions of cows classified as anovulatory or having no prior luteal activity compared with those classifications determined by concentrations of progesterone in blood serum. Overall accuracy of heatmount detectors and ultrasound was 71 and 84%, respectively. Application of progesterone to cows without a CL at the time of the first injection of GnRH reduced incidence of ovulation but improved pregnancy rates at day 33 or 61 compared with nontreated cows without a CL at the onset of the Ovsynch protocol. Pregnancy rates and pregnancy survival did not differ for cows having a CL before treatment compared with those not having a CL but treated with progesterone. Pregnancy rates were 1.5-fold greater for cows ovulating in response to the first GnRH injection. Timing of AI at 0 or 24 hours after the second GnRH injection did not alter pregnancy rates, but cows having prior luteal activity before treatment had improved pregnancy rates compared with anovulatory cows. We conclude that identifying anovulatory cows by ultrasound was more accurate than by heatmount detectors. Subsequent treatment of potential anovulatory cows with progesterone failed to improve fertility but had benefit for cows with prior estrous cycles at the onset of the timed AI (TAI) protocol, regardless of luteal status before the final luteolytic injection of PGF2α.; Dairy Day, 2007, Kansas State University, Manhattan, KS, 2007; Dairy Research, 2007 is known as Dairy Day, 200

Breaking conjugate pairing in thermostatted billiards by magnetic field

We demonstrate that in the thermostatted three-dimensional Lorentz gas the symmetry of the Lyapunov spectrum can be broken by adding to the system an external magnetic field not perpendicular to the electric field. For perpendicular field vectors, there is a Hamiltonian reformulation of the dynamics and the conjugate pairing rule still holds. This indicates that symmetric Lyapunov spectra has nothing to do with time reversal symmetry or reversibility; instead, it seems to be related to the existence of a Hamiltonian connection.Comment: 4 pages, 3 figure

Existence of superposition solutions for pulse propagation in nonlinear resonant media

Existence of self-similar, superposed pulse-train solutions of the nonlinear, coupled Maxwell-Schr\"odinger equations, with the frequencies controlled by the oscillator strengths of the transitions, is established. Some of these excitations are specific to the resonant media, with energy levels in the configurations of $\Lambda$ and $N$ and arise because of the interference effects of cnoidal waves, as evidenced from some recently discovered identities involving the Jacobian elliptic functions. Interestingly, these excitations also admit a dual interpretation as single pulse-trains, with widely different amplitudes, which can lead to substantially different field intensities and population densities in different atomic levels.Comment: 11 Pages, 6 Figures, presentation changed and 3 figures adde

Spatiotemporally localized solitons in resonantly absorbing Bragg reflectors

We predict the existence of spatiotemporal solitons (``light bullets'') in two-dimensional self-induced transparency media embedded in a Bragg grating. The "bullets" are found in an approximate analytical form, their stability being confirmed by direct simulations. These findings suggest new possibilities for signal transmission control and self-trapping of light.Comment: RevTex, 3 pages, 2 figures, to be published in PR