343 research outputs found
Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
Education in IT Security: A Case Study in Banking Industry
The banking industry has been changing incessantlyand facing new combination of risks. Data protection andcorporate security is now one of the major issues in bankingindustry. As the rapid changing on technologies from time totime, the industry should be aware on new technologies in orderto protect information assets and prevent fraud activities. Thispaper begins with literature study of information security issuesand followed by focused-group interviews with five participantswithin the industry and survey analysis of “The global state ofInformation Security survey 2013” which published byPriceWaterhouseCoopers (PWC). Trends and questions werediscussed as well as possible solution. The study suggests that ITsecurity education should be made to different level of staffs suchas executives, professional and general staffs. Besides, thebanking industry should increase company-wide securityawareness and the importance of corporate security which keepthe information and physical assets secure and in a proper way
Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
OBJECTIVE—The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy homeostasis by sensing nutritional and hormonal signals. However, the role of hypothalamic AMPK in glucose production regulation remains to be elucidated. We hypothesize that bidirectional changes in hypothalamic AMPK activity alter glucose production. RESEARCH DESIGN AND METHODS—To introduce bidirec-tional changes in hypothalamic AMPK activity in vivo, we first knocked down hypothalamic AMPK activity in male Sprague-Dawley rats by either injecting an adenovirus expressing the dominant-negative form of AMPK (Ad-DN AMPK2 [D157A]) or infusing AMPK inhibitor compound C directly into the medio-basal hypothalamus. Next, we independently activated hypotha-lamic AMPK by delivering either an adenovirus expressing the constitutive active form of AMPK (Ad-CA AMPK1312 [T172D]
Hypothalamic Protein Kinase C Regulates Glucose Production
OBJECTIVE—A selective rise in hypothalamic lipid metabolism and the subsequent activation of SUR1/Kir6.2 ATP-sensitive K+ (KATP) channels inhibit hepatic glucose production. The mechanisms that link the ability of hypothalamic lipid metabolism to the activation of KATP channels remain unknown
Automated mediator synthesis: combining behavioural and ontological reasoning
Software systems are increasingly composed of independently developed heterogeneous components. To ensure interoperability, mediators are needed that coordinate actions and translate exchanged messages between the components. We present a technique for automated synthesis of mediators, by means of a quotient operator, that is based on behavioural models of the components and an ontological model of the data domain. By not requiring a specification of the composed system, the method supports both off-line and run-time synthesis. The obtained mediator is the most general component that ensures freedom of both communication mismatches and deadlock in the composition. Validation of the approach is given by implementation of a prototype tool, while applicability is illustrated on heterogeneous holiday booking components
An intermediate-depth source of hydrothermal 3He and dissolved iron in the North Pacific
We observed large water column anomalies in helium isotopes and trace metal concentrations above the Loihi Seamount. The 3He/4He of the added helium was 27.3 times the atmospheric ratio, clearly marking its origin to a primitive mantle plume. The dissolved iron to 3He ratio (dFe:3He) exported to surrounding waters was 9.3 ± 0.3 × 106. We observed the Loihi 3He and dFe “signal” at a depth of 1100 m at several stations within ∼100 – 1000 km of Loihi, which exhibited a distal dFe:3He ratio of ∼4 × 106, about half the proximal ratio. These ratios were remarkably similar to those observed over and near the Southern East Pacific Rise (SEPR) despite greatly contrasting geochemical and volcanictectonic origins. In contrast, the proximal and distal dMn:3He ratios were both ∼ 1 × 106, less than half of that observed at the SEPR. Dissolved methane was minimally enriched in waters above Loihi Seamount and was distally absent. Using an idealized regional-scale model we replicated the historically observed regional 3He distribution, requiring a hydrothermal 3He source from Loihi of 10.4 ± 4.2 mola−1, ∼2% of the global abyssal hydrothermal 3He flux. From this we compute a corresponding dFe flux of ∼40 Mmola−1. Global circulation model simulations suggest that the Loihi-influenced waters eventually upwell along the west coast of North America, also extending into the shallow northwest Pacific, making it a possibly important determinant of marine primary production in the subpolar North Pacific
Sustainable bio-economy that delivers the environment-food-energy-water nexus objectives::the current status in Malaysia
Biomass is a promising resource in Malaysia for energy, fuels, and high value-added products. However, regards to biomass value chains, the numerous restrictions and challenges related to the economic and environmental features must be considered. The major concerns regarding the enlargement of biomass plantation is that it requires large amounts of land and environmental resources such as water and soil that arises the danger of creating severe damages to the ecosystem (e.g. deforestation, water pollution, soil depletion etc.). Regarded concerns can be diminished when all aspects associated with palm biomass conversion and utilization linked with environment, food, energy and water (EFEW) nexus to meet the standard requirement and to consider the potential impact on the nexus as a whole. Therefore, it is crucial to understand the detail interactions between all the components in the nexus once intended to look for the best solution to exploit the great potential of biomass. This paper offers an overview regarding the present potential biomass availability for energy production, technology readiness, feasibility study on the techno-economic analyses of the biomass utilization and the impact of this nexus on value chains. The agro-biomass resources potential and land suitability for different crops has been overviewed using satellite imageries and the outcomes of the nexus interactions should be incorporated in developmental policies on biomass. The paper finally discussed an insight of digitization of the agriculture industry as future strategy to modernize agriculture in Malaysia. Hence, this paper provides holistic overview of biomass competitiveness for sustainable bio-economy in Malaysia
Automatic service categorisation through machine learning in emergent middleware
The modern environment of mobile, pervasive, evolving services presents a great challenge to traditional solutions for enabling interoperability. Automated solutions appear to be the only way to achieve interoperability with the needed level of flexibility and scalability. While necessary, the techniques used to determine compatibility, as a precursor to interaction, come at a substantial computational cost, especially when checks are performed between systems in unrelated domains. To overcome this, we apply machine learning to extract high-level functionality information through text categorisation of a system's interface description. This categorisation allows us to restrict the scope of compatibility checks, giving an overall performance gain when conducting matchmaking between systems. We have evaluated our approach on a corpus of web service descriptions, where even with moderate categorisation accuracy, a substantial performance benefit can be found. This in turn improves the applicability of our overall approach for achieving interoperability in the Connect project
Effects of dual task on turning ability in stroke survivors and older adults
Background: Turning is an integral component of independent mobility in which stroke survivors frequently fall. Objective: This study sought to measure the effects of competing cognitive demands on the stepping patterns of stroke survivors, compared to healthy age-match adults, during turning as a putative mechanism for falls. Methods: Walking and turning (90º) was assessed under single (walking and turning alone) and dual task (subtracting serial 3s while walking and turning) conditions using an electronic, pressure-sensitive walkway. Dependent measures were time to turn, variability in time to turn, step length, step width and single support time during three steps of the turn. Turning ability in single and dual task conditions was compared between stroke survivors (n= 17, mean ± SD: 59 ± 113 months post-stroke, 64 ± 10 years of age) and age-matched healthy counterparts (n = 15). Results: Both groups took longer, were more variable, tended to widen the second step and, crucially, increased single support time on the inside leg of the turn while turning and distracted. Conclusions. Increased single support time during turning may represent biomechanical mechanism, within stepping patterns of turning under distraction, for increased risk of falls for both stroke survivors and older adults
- …