Study on absolute eosinophil count correlation with severity of bronchial asthma

Background: Bronchial asthma is defined as chronic inflammatory disease of the airways that is characterized by increased responsiveness of the tracheobronchial tree to a multiplicity of stimuli. Eosinophil infiltration is a characteristic feature of asthmatic airways. It presents as an obstructive type of ventilator defect usually diagnosed from a reduced FEV1% (Forced Expiratory Volume) or from a reduced peak expiratory flow (PEF) associated with reduced airway caliber during expiration. Allergen inhalation results in a marked increase in activated eosinophils in the airways. Correlation between the degree of bronchial hyperresponsiveness (a cardinal feature of asthma) and peripheral blood eosinophilia has been observed in patients with dual response following allergen challenge.Methods: The study comprises a total number of 50 bronchial asthma patients of both sexes (male and female) between the age groups of 13-65 years. Based on severity, asthma patients were classified into mild, moderate and severe asthmatics, assessed by FEV1% computerized Spirometry Helios model number 701, recorders and medicare system. Peripheral blood sample was collected from each patient for absolute eosinophil count, the count was done on the same day.Results: The mean±SD absolute eosinophil count of 50 patients is 330±88.64 which is slightly above normal (300 cells/mm3). Author found that the mean±SD absolute eosinophil count of 405±83.16 in severe asthma patients is quite high, corresponding with a steep decline in the FEV1% 45.3±12.6.Conclusions: Absolute eosinophil count and FEV1% are important indicators of bronchial asthma severity and can even be used to predict disease progression

A COMPREHENSIVE REVIEW ON IN VITRO ANTHELMINTIC ACTIVITIES OF SOME AYURVEDIC PLANTS

Ayurveda, the Science of life, commonly uses medicinal plants for treating various diseases. Numerous medicinal plants are being used traditionally for treating parasitic infections in India. In Ayurveda, worm infestation in the gastro intestinal tract is known as Krimi roga. Many Ayurvdeic medicinal plants are used traditionally for treating Krimi roga. Use of synthetic drugs anthelmintic for treating parasitic infestations causes serious toxic side effects in human. Use of Ayurvedic plants has no such side effects and, economical. The paper highlights anthelmintic activities of some of the most important Ayurvedic medicinal plants carried out in vitro in various pharmacological models. A brief review of In vitro anthelmintic activities of thirteen Ayurvedic medicinal plants published by various researchers is illustrated in this paper. The medicinal plants discussed here are Vidanga: Embelia ribes Burm. F, Kalmegh: Andrographis paniculata (Burm.f.) Nees, Gunja: Abrus precatorius L., Kiratatikta: Swertia chirata L., Khadira: Acacia catechu (L.f.) Willd., Ativisha: Aconitum heterophyllum Wall. ex Royle, Saptaparna: Alstonia scholaris (L.) R. Br., Aragvadha: Cassia fistula L., Nimba (Azadirahcta indica A. Juss.), Brahmi: Bacopa monnieri (L.) Penn., Mandukaparni: Centella asiatica (L.) Urban, Vacha: Acorus calamus L. and Chirbhita: Carica papaya L

GENERALIZED ESTIMATING EQUATION IN PHARMACOLOGICAL STUDY

Generalized Estimating Equation (GEE) deals with such data that do not have normal distribution in case of repeated experiment and has better properties as compared to rANOVA. With the objective to describe the use of GEE in pharmacological study this endeavour started. GEE described hereby using rat data. Four correlation structured were taken in GEE. It was found Independent/Exchangeable structure best suited with data. The model fit on data was assessed graphically as well. The trend line of repeated data for all cases (rats) were fallen in 95 % bound of predicted model. The model gave the average weight of rat 226.51 gram with start of experiment and it increases 8.67gram per week after feeding high fat diet

Potentilla fulgens Wall

ABSTRACT The paper highlights some of the most important Ayurvedic medicinal plants of North Eastern India having anticancer potential. A brief review of distribution and pharmacological study (both in vivo and in vitro) of ten Ayurvedic medicinal plants of the region published by various researchers is illustrated in this paper. The medicinal plants discussed here are Enhydra Fluctuans Lour (Sanskrit: Hilamochika), Ageratum conizoides Linn

Fundamental flow problems considering non-Newtonian hyperbolic tangent fluid with Navier slip: Homotopy analysis method

The presented research article deals with the classical fundamental flows (Poiseuille and Couette) of an incompressible hyperbolic tangent fluid while considering the Navier slip at the walls. The governing equations are solved using the homotopy analysis method. The velocity expressions are obtained for each problem and the effect of the flow parameters are discussed while being supplemented by graphical displays. Increasing the slip parameter reduces the fluid velocity for both problems, respectively. An increase in the Weissenberg number shows that skin friction at the lower wall reduces. This shows that a dominant elastic force is crucial in reducing the skin friction

PHARMACOLOGICAL AND THERAPEUTIC PROFILE OF ANANTAMULA (HEMIDESMUS INDICUS (L.) R. BR.): A COMPREHENSIVE REVIEW

The vast field of Ayurvedic science is gaining more importance and popularity throughout the world because of its amazing therapeutic value. Since the beginning of human civilization, medicinal plants have been used by mankind for its therapeutic value. The World Health Organization estimated that 80% of people worldwide rely on herbal medicines for some aspect of their primary healthcare. Hemidesmus indicus is a widely used shrub in Indian folk medicine and considered as magical spiritual dream herb in Ayurvedic medication. It is used as a vital herb for healing many ailments and to treat diversified diseases. Following a large number of claims on the wide range of traditional medicinal properties of the plants, considerable effort have been made to verify its efficacy as a curative agent through pharmacological investigations. Different pharmacological experiments in vitro and in vivo models convincingly demonstrated the ability of Anantamula to exhibit analgesic, anti-inflammatory, antipyretic, antiarthritic, antioxidant, hepatoprotective, nephroprotective, antiepileptic, anticonvulsant, antileprotic, antiacne, antipsychotic, nootropic, antinociceptive, antidiarrhoeal, antigenotoxic, antiangiogenic, wound healing, antiulcer, larvicidal, antivenom, antithrombotic, antihyperlipaedaemic, antimicrobial and anticarcinogenic activities due to its remarka­ble biological activity and bioactive constituents. This plant is a good source of different bioactive chemical compound like Hemidesmin-1 and Hemidesmin-2, α-amyrin, β-amyrin, lupeol acetate, β-sitosterol, hemidesmol and hemidesterol which were responsible for many of the pharmacological activities. This review aims at providing an up-to-date overview of comprehensive account of the phytochemical investigation, therapeutic potential and pharmacological studies of Hemidesmus indicus