Effect of Imperceptible Vibratory Noise Applied to Wrist Skin On Fingertip Touch Evoked Potentials – An EEG Study

Random vibration applied to skin can change the sense of touch. Specifically, low amplitude white-noise vibration can improve fingertip touch perception. In fact, fingertip touch sensation can improve even when imperceptible random vibration is applied to other remote upper extremity areas such as wrist, dorsum of the hand, or forearm. As such, vibration can be used to manipulate sensory feedback and improve dexterity, particularly during neurological rehabilitation. Nonetheless, the neurological bases for remote vibration enhanced sensory feedback are yet poorly understood. This study examined how imperceptible random vibration applied to the wrist changes cortical activity for fingertip sensation. We measured somatosensory evoked potentials to assess peak-to-peak response to light touch of the index fingertip with applied wrist vibration versus without. We observed increased peak-to-peak somatosensory evoked potentials with wrist vibration, especially with increased amplitude of the later component for the somatosensory, motor, and premotor cortex with wrist vibration. These findings corroborate an enhanced cortical-level sensory response motivated by vibration. It is possible that the cortical modulation observed here is the result of the establishment of transient networks for improved perception

Conditional preparation of states containing a definite number of photons

A technique for conditionally creating single- or multimode photon-number states is analyzed using Bayesian theory. We consider the heralded N-photon states created from the photons produced by an unseeded optical parametric amplifier when the heralding detector is the time-multiplexed photon-number-resolving detector recently demonstrated by Fitch, et al. [Phys. Rev. A 68, 043814 (2003).] and simultaneously by Achilles, et al. [Opt. Lett. 28, 2387 (2003).]. We find that even with significant loss in the heralding detector, fields with sub-Poissonian photon-number distributions can be created. We also show that heralded multimode fields created using this technique are more robust against detector loss than are single-mode fields.Comment: 6 pages, 6 figures, reference added, typos corrected, content update

Quality of diabetes care worldwide and feasibility of implementation of the Alphabet Strategy : GAIA project (Global Alphabet Strategy Implementation Audit)

Backfround: The Alphabet Strategy (AS) is a diabetes care checklist ensuring "important, simple things are done right all the time." Current audits of diabetes care in developed countries reveal wide variations in quality with performance of care processes frequently sub-optimal. This study had three components: an audit to assess diabetes care quality worldwide, a questionnaire study seeking opinions on the merits of the AS, a pilot study to assess the practicality of implementation of the AS in a low socioeconomic setting. Methods: Audit data was collected from 52 centres across 32 countries. Data from 4537 patients were converted to Quality and Outcome Framework (QOF) scores to enable inter-centre comparison. These were compared to each country's Gross Domestic Product (GDP), and Total Health Expenditure percentage per capita (THE%). The opinions of diabetes patients and healthcare professionals from the diabetes care team at each of these centres were sought through a structured questionnaire. A retrospective audit on 100 randomly selected case notes was conducted prior to AS implementation in a diabetes outpatient clinic in India, followed by a prospective audit after four months to assess its impact on care quality. Results: QOF scores showed wide variation across the centres (mean 49.0, range 10.2-90.1). Although there was a positive relationship between GDP and THE% to QOF scores, there were exceptions. 91% of healthcare professionals felt the AS approach was practical. Patients found the checklist to be a useful education tool. Significant improvements in several aspects of care as well as 36% improvement in QOF score were seen following implementation. Conclusions: International centres observed large variations in care quality, with standards frequently sub-optimal. 71% of health care professionals would consider adopting the AS in their daily practice. Implementation in a low resource country resulted in significant improvements in some aspects of diabetes care. The AS checklist for diabetes care is a freely available in the public domain encompassing patient education, care plans, and educational resources for healthcare professionals including summary guidelines. The AS may provide a unique approach in delivering high quality diabetes care in countries with limited resources

Validating secure and reliable IP/MPLS communications for current differential protection

Current differential protection has stringent real-time communications requirements and it is critical that protection traffic is transmitted securely, i.e., by using appropriate data authentication and encryption methods. This paper demonstrates that real-time encryption of protection traffic in IP/MPLS-based communications networks is possible with negligible impact on performance and system operation. It is also shown how the impact of jitter and asymmetrical delay in real communications networks can be eliminated. These results will provide confidence to power utilities that modern IP/MPLS infrastructure can securely and reliably cater for even the most demanding applications

Cellular Hydraulics Suggests a Poroelastic Cytoplasm Rheology

The cytoplasm represents the largest part of the cell by volume and hence its rheology sets the rate at which cellular shape change can occur. Recent experimental evidence suggests that cytoplasmic rheology can be described using a poroelastic formulation in which the cytoplasm is considered a biphasic material constituted of a porous elastic solid meshwork (cytoskeleton, organelles, macromolecules) bathed in an interstitial fluid (cytosol). In this picture, the rate of cellular deformation is limited by the rate at which intracellular water can redistribute within the cytoplasm. Though this is a conceptually attractive model, direct supporting evidence has been lacking. Here we present such evidence and directly validate this concept to explain cellular rheology at physiologically relevant time-scales using microindentation tests in conjunction with mechanical, chemical and genetic treatments. Our results show that water redistribution through the solid phase of cytoplasm (cytoskeleton and crowders) plays a fundamental role in setting cellular rheology.Engineering and Applied Science

Management of undescended testes: a comparative study in England and Africa

Objective The aim of our study was to determine the timing of referrals and the outcome of undescended testes (UDT) over a 4-year period in a tertiary centre in England, and to compare this with a similar centre in Nigeria. Background data Cryptorchidism is a recognized cause of infertility and a key risk factor for testicular malignancy. Current recommendations are that orchidopexy be performed between 12 and 18 months of age; however, there is no consensus on this.Materials and methods Data were obtained for orchidopexies performed between 2003 and 2007 from a tertiary referral centre in England. A standardized proforma was used to collect data into an Excel database, which was analysed and compared with data from a similar centre in Nigeria.Results Eighty-eight patients from a tertiary referral centre in England underwent surgery for UDT. Fifty-six (63.6%) patients were referred and 38 (43.2%) patients were operated on within 2 years of age. Doctors and health visitors accounted for 69 (78.5%) referrals to the tertiary centre. Data from Nigeria demonstrated that of the 61 cases, 13 (21%) patients presented and 11 (18%) patients were operated on by 24 months. Referral beyond 60 months of age in the English series was due to ascending testis, whereas in the Nigerian study, the delayed presentation was due to delayed referral from lack of knowledge of the condition.Conclusion In England and Nigeria, there is a lack of definitive guidelines relating to the appropriate age of referral of patients with UDT. A structured care pathway is needed to enable early detection and definitive management

A cross-layer architecture to improve mobile host rate performance and to solve unfairness problem in WLANs

The evolution of the Internet has been mainly promoted in recent years by the emergence and pro- liferation of wireless access networks towards a global ambient and pervasive network accessed from mobile devices. These new access networks have introduced new MAC layers independently of the legacy "wire- oriented" protocols that are still at the heart of the pro- tocol stacks of the end systems. This principle of isola- tion and independence between layers advocated by the OSI model has its drawbacks of maladjustment between new access methods and higher-level protocols built on the assumption of a wired Internet. In this paper, we introduce and deliver solutions for several pathologi- cal communication behaviors resulting from the malad- justment between WLAN MAC and higher layer stan- dard protocols such as TCP/IP and UDP/IP. Specially, based on an efficient analytical model for WLANs band- width estimation, we address in this paper the two fol- lowing issues: 1) Performance degradation due to the lack of flow control between the MAC and upper layer resulting in potential MAC buffer overflow; 2) Unfair bandwidth share issues between various type of flows. We show how these syndromes can be efficiently solved from neutral "cross layer" interactions which entail no changes in the considered protocols and standards

A UK wide cohort study describing management and outcomes for infants with surgical Necrotising Enterocolitis

The Royal College of Surgeons have proposed using outcomes from necrotising enterocolitis (NEC) surgery for revalidation of neonatal surgeons. The aim of this study was therefore to calculate the number of infants in the UK/Ireland with surgical NEC and describe outcomes that could be used for national benchmarking and counselling of parents. A prospective nationwide cohort study of every infant requiring surgical intervention for NEC in the UK was conducted between 01/03/13 and 28/02/14. Primary outcome was mortality at 28-days. Secondary outcomes included discharge, post-operative complication, and TPN requirement. 236 infants were included, 43(18%) of whom died, and eight(3%) of whom were discharged prior to 28-days post decision to intervene surgically. Sixty infants who underwent laparotomy (27%) experienced a complication, and 67(35%) of those who were alive at 28 days were parenteral nutrition free. Following multi-variable modelling, presence of a non-cardiac congenital anomaly (aOR 5.17, 95% CI 1.9-14.1), abdominal wall erythema or discolouration at presentation (aOR 2.51, 95% CI 1.23-5.1), diagnosis of single intestinal perforation at laparotomy (aOR 3.1 95% CI 1.05-9.3), and necessity to perform a clip and drop procedure (aOR 30, 95% CI 3.9-237) were associated with increased 28-day mortality. These results can be used for national benchmarking and counselling of parents

Does training with amplitude modulated tones affect tone-vocoded speech perception?

Temporal-envelope cues are essential for successful speech perception. We asked here whether training on stimuli containing temporal-envelope cues without speech content can improve the perception of spectrally-degraded (vocoded) speech in which the temporal-envelope (but not the temporal fine structure) is mainly preserved. Two groups of listeners were trained on different amplitude-modulation (AM) based tasks, either AM detection or AM-rate discrimination (21 blocks of 60 trials during two days, 1260 trials; frequency range: 4Hz, 8Hz, and 16Hz), while an additional control group did not undertake any training. Consonant identification in vocoded vowel-consonant-vowel stimuli was tested before and after training on the AM tasks (or at an equivalent time interval for the control group). Following training, only the trained groups showed a significant improvement in the perception of vocoded speech, but the improvement did not significantly differ from that observed for controls. Thus, we do not find convincing evidence that this amount of training with temporal-envelope cues without speech content provide significant benefit for vocoded speech intelligibility. Alternative training regimens using vocoded speech along the linguistic hierarchy should be explored