Universities' mundaneness and regional engagement : Setting the stage

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Universities and regions : New insights and emerging developments

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Unpacking Mundaneness : A novel conceptual framework for universities and regional engagement

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Responses to the Global Financial Crisis - Lessons From the Public Sector in the Nordic Countries

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A bidirectional study of the association between insomnia, high-sensitivity C-reactive protein, and comorbid low back pain and lower limb pain

Objectives - To examine the possible bidirectional association between insomnia and comorbid chronic low back pain (LBP) and lower limb pain and to explore whether high-sensitivity C-reactive protein (hsCRP) amplifies these associations. Methods - We calculated adjusted risk ratios (RR) with 95% confidence intervals (CI) for the development of insomnia and mild-to-severe chronic LBP and lower limb pain at 11 years follow-up in participants aged ≥32 years and with hsCRP ≤10 mg/L at baseline in 2007–2008: 3,714 without chronic LBP or lower limb pain (sample 1) and 7,892 without insomnia (sample 2). Results - Compared to participants without chronic pain, participants with comorbid chronic LBP and lower limb pain had a RR of insomnia of 1.37 (95% CI 1.12–1.66). Compared with participants without insomnia, participants with insomnia did not have an increased risk of comorbid chronic LBP and lower limb pain (RR: 1.06, 95% CI 0.76–1.46); however, participants with insomnia had a RR of chronic LBP of 1.20 (95% CI 1.02–1.42). There was no strong amplifying effect of elevated hsCRP (3.00–10.0 mg/L) on these associations. Conclusions - These findings suggest that elevated hsCRP does not amplify the associations between insomnia and mild-to-severe chronic LBP and lower limb pain. Further research using data on the temporal relation between insomnia, chronic pain, and inflammatory responses are required to fully understand the causal pathways

Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi.

Enriched environments normally increase behavioral repertoires and diminish the expression of abnormal behaviors and stress-related physiological problems in animals. Although it has been shown that experimental animals infected with microorganisms can modify their behaviors and physiology, few studies have evaluated how environmental enrichment affects these parameters. This study aimed to evaluate the effects of environmental enrichment on the behavior and physiology of confined mice infected with Trypanosoma cruzi

Profilaxia antibiótica para prevenção da Endocardite bacteriana: uma revisão de literatura

O endocárdio, tecido que reveste as estruturas internas do coração, quando colonizado por bactérias ou fungos patogênicos, pode levar à endocardite infecciosa (EI), uma condição grave. Há correlações entre procedimentos odontológicos e a EI, levantando debates sobre profilaxia antibiótica. O objetivo do estudo é avaliar a eficácia de antibióticos na profilaxia de pacientes com cardiopatias. Foi realizada uma revisão de literatura que avaliou a eficácia da administração pré-operatória de antibióticos em pacientes com cardiopatias submetidos. Os estudos considerados foram publicados entre 2018 e 2022 em português, inglês e espanhol, com descritores científicos "Antibiotic Prophylaxis", "Surgery, Oral" and "Endocarditis, Bacterial” e “Heart Valve Diseases”, relacionados ao tratamento odontológico com antibióticos. A EI afeta principalmente homens idosos e tem alta incidência no Brasil, se manifestando com sintomas como febre, calafrios e pode levar a consequências graves. Os principais fatores de risco incluem idade avançada, próteses cardíacas, corticoesteroides e cardiopatias, com Staphylococcus como o agente bacteriano mais comum.  Pacientes com alto risco de desenvolver EI após procedimentos cirúrgicos incluem aqueles com comorbidades, histórico de cardiopatias, doenças cardíacas complexas e derivações pulmonares reconstruídas precisam realizar antibioticoprofilaxia. Pacientes com risco mínimo não necessitam. A antibioticoprofilaxia em procedimentos odontológicos é viável e prudente em pacientes com cardiopatias, prevenindo a endocardite bacteriana e oferecendo segurança. Desse modo, este trabalho busca elucidar o papel dos antibióticos no contexto da profilaxia como prevenção a endocardite bacteriana