PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL DAN KOMPENSASI TERHADAP KEPUASAN KERJA KARYAWAN PT. KERETA API INDONESIA (PERSERO) BANDUNG

ABSTRAK Iin Clarisa Lahita (1506014), Pengaruh Kepemimpinan Transformasional dan Kompensasi terhadap Kepuasan Kerja Karyawan PT. Kereta Api Indonesia (Persero) Bandung, dibawah bimbingan Askolani, SE., MM dan Annisa Ciptagustia, SE., M.Si. Fokus utama penelitian adalah kepuasan kerja karyawan PT. Kereta Api Indonesia (Persero) Bandung. Dari banyaknya faktor yang mempengaruhi kepuasan kerja karyawan, yang menarik peneliti adalah kepemimpinan transformasional dan kompensasi. PT. Kereta Api Indonesia (Persero) merupakan perusahaan di bidang jasa transportasi yang membutuhkan sumber daya manusia yang berkualitas, sehingga perusahaan terus berusaha untuk meningkatkan kepuasan kerja karyawannya. Tujuan penelitian ini adalah untuk mengetahui gambaran mengenai kepemimpinan transformasional, kompensasi dan kepuasan kerja karyawan PT. Kereta Api Indonesia (Persero), pengaruh kepemimpinan transformasional terhadap kepuasan kerja karyawan, pengaruh kompensasi terhadap kepuasan kerja karyawan, dan pengaruh kepemimpinan transformasional dan kompensasi terhadap kepuasan kerja karyawan. Penelitian ini menggunakan metode deskriptif dan verifikatif dengan populasi dan sampel sejumlah 110 karyawan. Dengan menggunakan teknik pengumpulan data kuesioner dan studi kepustakaan. Teknik analisis yang digunakan adalah koefisien korelasi pearson product moment dan analisis regresi linier berganda. Pengujian hipotesis menggunakan uji T dan uji F. Hasil penelitian menunjukan gambaran kepemimpinan transformasional, kompensasi dan kepuasan kerja karyawan PT. Kereta Api Indonesia (Persero) berada pada kategori tinggi. Perhitungan korelasi menunjukan bahwa kepemimpinan transformasional dengan kepuasan kerja karyawan memiliki hubungan yang positif dan signifikan dengan klasifikasi tinggi, sedangkan kompensasi dengan kepuasan kerja karyawan memiliki hubungan yang positif dan signifikan dengan klasifikasi tinggi. Dari hasil uji korelasi kepuasan kerja karyawan dipengaruhi oleh kepemimpinan transformasional dan kompensasi sebesar 47,3% Kata Kunci : Kepemimpinan Transformasional, Kompensasi, Kepuasan Kerja Karyawan   ABSTRACT Iin Clarisa Lahita (1506014), The Impact of Transformational Leadership and Compensation towards Employee Job Satisfaction of PT. Kereta Api Indonesia (Persero) Bandung, under the guidance of Askolani, SE., MM dan Annisa Ciptagustia, SE., M.Si. The main focus of research is the employee job satisfaction of PT. Kereta Api Indonesia (Persero) Bandung. Of the many factors that affect employee job satisfaction, what attracts researcher is transformational leadership and compensation. PT. Kereta Api Indonesia (Persero) is a company in the field of transportation services that requires quality human resources, so the company continues to strive to improve job satisfaction of its employees. The purpose of this study are to find the description of transformational leadership, compensation and employee job satisfaction of PT. Kereta Api Indonesia (Persero), the impact of transformational leadership on employee job satisfaction, the impact of compensation on employee job satisfaction, and the impact of transformational leadership and compensation on employee job satisfaction. This study uses descriptive and verification method with population and sample of 110 employees. By using questionnaire data collection technique and literature study. Analysis technique used are correlation coefficient pearson product moment and multiple linear regression analysis. Hypothesis testing using T test and F test. The results showed the implementation of transformational leadership, compensation and employee job satisfaction of PT. Kereta Api Indonesia (Persero) are in the high category. Correlation calculation shows that transformational leadership and employee job satisfaction has a positive and significant relationship with high classification, while compensation and employee job satisfaction has a positive and significant relationship with high classification. From the results of the correlation test employee satisfaction is influenced by transformational leadership and compensation by 47.3%. Keywords : Transformational Leadership, Compensation, Employee Job Satisfactio

Ariel - Volume 5 Number 4

Editors Mark Dembert J.D. Kanofskv Entertainment Editors Robert Breckenridge Joe Conti Overseas Editor Mike Sinason Photographer Scott Kastner Epistemologist Gary Kaskey Staff Ken Jaffe Bob Sklaroff Janet Weish David Jacoby Phil Nimoityn Circulation Editor Jay Amsterdam Humorist Jim Mccan

Ariel - Volume 4 Number 4

Editors David A. Jacoby Eugenia Miller Tom Williams Associate Editors Paul Bialas Terry Burt Michael Leo Gail Tenikat Editor Emeritus and Business Manager Richard J. Bonnano Movie Editor Robert Breckenridge Staff Richard Blutstein Mary F. Buechler Meg Brunt Steve Glinks Len Grasman Alice M. Johnson J.D. Kanofsky Tom Lehman Dave Mayer Bernie Odd

Ariel - Volume 4 Number 5

Editors David A. Jacoby Eugenia Miller Tom Williams Associate Editors Paul Bialas Terry Burt Michael Leo Gail Tenikat Editor Emeritus and Business Manager Richard J. Bonnano Movie Editor Robert Breckenridge Staff Richard. Blutstein Mary F. Buechler Alice M. Johnson J.D. Kanofskv Rocky Webe

Acceleration of Autoimmunity by Organochlorine Pesticides in (NZB × NZW)F(1) Mice

Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects women more frequently than men. In the (NZB × NZW)F(1) mouse, a murine SLE model, the presence or absence of estrogen markedly influences the rate of progression of disease. Three organochlorine pesticides with estrogenic effects were administered chronically to ovariectomized female (NZB × NZW)F(1) mice, and we measured the time to development of renal disease, the principal clinical manifestation of lupus in this model. Treatment with chlordecone, methoxychlor, or o,p′-dichlorodiphenyl-trichloroethane (o,p′-DDT) significantly decreased the time to onset of renal impairment, as did treatment with 17β-estradiol used as a positive control. In an expanded study of chlordecone, we found a dose-related early appearance of elevated anti–double-strand DNA autoantibody titers that corresponded with subsequent development of glomerulonephritis. Immunohistofluorescence confirmed early deposition of immune complexes in kidneys of mice treated with chlordecone. These observations are consistent with an effect of these organochlorine pesticides to accelerate the natural course of SLE in the (NZB × NZW)F(1) mouse. Although we originally hypothesized that the effect on progression of autoimmunity was due to estrogenic properties of the pesticides, autoimmune effects and estrogenicity, assessed through measurement of uterine hypertrophy, were not well correlated. This may indicate that uterine hypertrophy is a poor indicator of comparative estrogenic effects of organochlorine pesticides on the immune system, or that the pesticides are influencing autoimmunity through a mode of action unrelated to their estrogenicity

Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease

Objective To describe the myelodysplastic syndromes (MDS) and cytogenetic abnormalities that occur in patients who have been treated with alkylating drugs for their rheumatic disease. Methods Patients with rheumatic disease who developed MDS after current or previous treatment with alkylating drugs were selected for evaluation by chart review and cytogenetic studies. Results Eight patients with rheumatic disease (mean age 56.9 years) developed MDS over the study period. Seven had received oral cyclophosphamide and 1 chlorambucil as their main immunosuppressive drug. The mean total cumulative dose of cyclophosphamide or chlorambucil was 118 gm and 6.5 gm, respectively, over a period of 2-10 years. The cytogenetic abnormalities included adeletion of all or part of chromosome 7 in 5 patients, while 4 had a deletion of part of the long arm of chromosome 5. Six of the patients have since died. Conclusion Large cumulative doses of cyclophosphamide and chlorambucil were associated with the development of MDS, the occurrence of abnormalities of chromosome 5 and/or chromosome 7 deletions, and a poor prognosis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37816/1/21_ftp.pd

Age-related changes in Serum Growth Hormone, Insulin-like Growth Factor-1 and Somatostatin in System Lupus Erythematosus

BACKGROUND: Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also involve growth hormone, insulin-like growth factor-1 and somatostatin function. This study was designed to compare basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels in female systemic lupus erythematosus patients to a group of normal female subjects. METHODS: Basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels were measured by standard radioimmunoassay. RESULTS: Serum growth hormone levels failed to correlate with age (r(2 )= 3.03) in the entire group of normal subjects (i.e. 20 – 80 years). In contrast, serum insulin-like growth factor-1 levels were inversely correlated with age (adjusted r(2 )= 0.092). Of note, serum growth hormone was positively correlated with age (adjusted r(2 )= 0.269) in the 20 – 46 year range which overlapped with the age range of patients in the systemic lupus erythematosus group. In that regard, serum growth hormone levels were not significantly higher compared to either the entire group of normal subjects (20 – 80 yrs) or to normal subjects age-matched to the systemic lupus erythematosus patients. Serum insulin-like growth factor-1 levels were significantly elevated (p < 0.001) in systemic lupus erythematosus patients, but only when compared to the entire group of normal subjects. Serum somatostatin levels differed from normal subjects only in older (i.e. >55 yrs) systemic lupus erythematosus patients. CONCLUSIONS: These results indicated that systemic lupus erythematosus was not characterized by a modulation of the growth hormone/insulin-like growth factor-1 paracrine axis when serum samples from systemic lupus erythematosus patients were compared to age- matched normal female subjects. These results in systemic lupus erythematosus differ from those previously reported in other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, fibromyalgia, diffuse idiopathic skeletal hyperostosis and hypermobility syndrome where significantly higher serum growth hormone levels were found. Somatostatin levels in elderly systemic lupus erythematosus patients may provide a clinical marker of disease activity in these patients

Maternal neurofascin-specific autoantibodies bind to structures of the fetal nervous system during pregnancy, but have no long term effect on development in the rat

Neurofascin was recently reported as a target for axopathic autoantibodies in patients with multiple sclerosis (MS), a response that will exacerbate axonal pathology and disease severity in an animal model of multiple sclerosis. As transplacental transfer of maternal autoantibodies can permanently damage the developing nervous system we investigated whether intrauterine exposure to this neurofascin-specific response had any detrimental effect on white matter tract development. To address this question we intravenously injected pregnant rats with either a pathogenic anti-neurofascin monoclonal antibody or an appropriate isotype control on days 15 and 18 of pregnancy, respectively, to mimic the physiological concentration of maternal antibodies in the circulation of the fetus towards the end of pregnancy. Pups were monitored daily with respect to litter size, birth weight, growth and motor development. Histological studies were performed on E20 embryos and pups sacrificed on days 2, 10, 21, 32 and 45 days post partum. Results: Immunohistochemistry for light and confocal microscopy confirmed passively transferred anti-neurofascin antibody had crossed the placenta to bind to distinct structures in the developing cortex and cerebellum. However, this did not result in any significant differences in litter size, birth weight, or general physical development between litters from control mothers or those treated with the neurofascin-specific antibody. Histological analysis also failed to identify any neuronal or white matter tract abnormalities induced by the neurofascin-specific antibody. Conclusions: We show that transplacental transfer of circulating anti-neurofascin antibodies can occur and targets specific structures in the CNS of the developing fetus. However, this did not result in any pre- or post-natal abnormalities in the offspring of the treated mothers. These results assure that even if anti-neurofascin responses are detected in pregnant women with multiple sclerosis these are unlikely to have a negative effect on their children

Myopericarditis in a Korean Young Male With Systemic Lupus Erythematosus

Myocardial involvement with clinical symptoms is a rare manifestation of systemic lupus erythematosus (SLE), despite the relatively high prevalence of myocarditis at autopsies of SLE patients. In this review, we report the case of a 19-year-old male SLE patient who initially presented with myopericarditis and was successfully treated with high dose of glucocorticoids