Using delayed damping to minimize transmitted vibrations

, it was shown that in a single degree of freedom system a fast nonlinear parametric damping enhances vibration isolation with respect to the case where the nonlinear damping is time-independent. The present work proposes additional enhancement of vibration isolation using delayed nonlinear damping. Attention is focused on assessing the contribution of a delayed nonlinear damping over a fast parametric damping in terms of minimizing transmissibility. The results show that a nonlinear damping with delay greatly improves vibration isolation

Galloping of Wind-excited Tower under External Excitation and Parametric Damping

Abstract This paper investigates the in luence of combined fast external excitation and parametric damping on the amplitude and the onset of galloping of a tower submitted to steady and unsteady wind low. A lumped single degree of freedom model is considered and the cases where the turbulent wind activates either external excitation, parametric one or both are studied. The methods of direct partition of motion and the multiple scales are used to drive the slow low near primary resonance. The in luence of the combined excitation on the galloping is examined. The results shown that not only the amplitude of galloping is in luenced, but also the onset of galloping

J Hypertens

OBJECTIVE: Heart failure with preserved left-ventricular ejection fraction (HF-PEF) is an entity leading to pulmonary congestion because of impaired diastolic filling. This syndrome usually strikes those who have experienced a long history of hypertension or metabolic risk factors. Pathophysiological mechanisms are not fully understood, and standard therapy is not established. Relevant preclinical models are still lacking. The aim of this work was to evaluate aging spontaneously hypertensive rats (SHRs) as a model of HF-PEF. METHODS: Serial echocardiographic and blood pressure (BP) measurements were performed in 28, 36, 43, 47 and 51-week-old SHRs and their normotensive controls (Wistar-Kyoto rats). In 52-53-week-old animals, final investigations included ECG, invasive left-ventricular (LV) and aortic catheterization, brain natriuretic peptide (BNP) plasma concentrations, ventricular reverse transcription-qPCR evaluations (beta-myosin heavy chain, atrial natriuretic peptide, BNP, sarco/endoplasmic reticulum calcium ATPase 2a and collagens 1a, 3a and 2a) and cardiac histology. RESULTS: SHRs develop a progressive alteration of the early diastole, some of the echocardiographic parameters being not sensitive to BP reduction by the calcium blocker, nicardipine. The systolic function evaluated by echocardiography and invasive catheterization was preserved. When the observation period was over, an increase in collagen synthesis and deposits were identified in subendocardial layers. This attested a probable myocardial ischemia that was confirmed by ECG changes of the ST segment. BNP increased in the blood and at the mRNA level in the myocardium. CONCLUSION: When aging, SHRs progressively develop HF-PEF showed by impaired LV relaxation and hypertrophy, BNP increase but preserved contractility and fibrosis. This model seems pertinent for further pharmacological preclinical studies in the field

Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats

International audienceLeft-ventricular hypertrophy and interstitial fibrosis are the main pathophysiological factors of heart failure with preserved ejection fraction. Blockade of the serotonin 5-HT2B receptor (5-HT2BR) has been shown to reduce cardiac hypertrophy, oxidative stress, and extracellular cell matrix activation. In this study, we evaluated the effects of the 5-HT2BR blockade, on hemodynamic and cardiac remodeling, in spontaneously hypertensive rats (SHRs) that display a diastolic dysfunction with preserved ejection fraction