Filosofía de la acción histórica

La reunión que hemos mantenido hoy ha sido impresionante por la significación que ella tiene. En primerísimo lugar, sin duda, en razón de la presencia del Padre Scannone entre nosotros, por lo que él representa de por sí, y también, me parece -y creo que ustedes serán del mismo parecer-, porque es el portavoz, primero, de los hermanos jesuítas con los que realiza el trabajo filosófico del que nos ha hablado, pero también del pueblo cuya experiencia el Padre Scannone intenta comprender: el pueblo de América Latina, que ha estado presente constantemente en su discurso

Early acute microvascular kidney transplant rejection in the absence of anti-HLA antibodies is associated with preformed IgG antibodies against diverse glomerular endothelial cell antigens

International audienceBACKGROUND: Although anti-HLA antibodies (Abs) cause most antibody-mediated rejections of renal allografts, non-anti-HLA Abs have also been postulated to contribute. A better understanding of such Abs in rejection is needed.METHODS: We conducted a nationwide study to identify kidney transplant recipients without anti-HLA donor-specific Abs who experienced acute graft dysfunction within 3 months after transplantation and showed evidence of microvascular injury, called acute microvascular rejection (AMVR). We developed a crossmatch assay to assess serum reactivity to human microvascular endothelial cells, and used a combination of transcriptomic and proteomic approaches to identify non-HLA Abs.RESULTS: We identified a highly selected cohort of 38 patients with early acute AMVR. Biopsy specimens revealed intense microvascular inflammation and the presence of vasculitis (in 60.5%), interstitial hemorrhages (31.6%), or thrombotic microangiopathy (15.8%). Serum samples collected at the time of transplant showed that previously proposed anti-endothelial cell Abs-angiotensin type 1 receptor (AT1R), endothelin-1 type A and natural polyreactive Abs-did not increase significantly among patients with AMVR compared with a control group of stable kidney transplant recipients. However, 26% of the tested AMVR samples were positive for AT1R Abs when a threshold of 10 IU/ml was used. The crossmatch assay identified a common IgG response that was specifically directed against constitutively expressed antigens of microvascular glomerular cells in patients with AMVR. Transcriptomic and proteomic analyses identified new targets of non-HLA Abs, with little redundancy among individuals.CONCLUSIONS: Our findings indicate that preformed IgG Abs targeting non-HLA antigens expressed on glomerular endothelial cells are associated with early AMVR, and that cell-based assays are needed to improve risk assessments before transplant

In memoriam le professeur Joseph Dopp

Ladrière Jean. In memoriam le professeur Joseph Dopp. In: Revue Philosophique de Louvain. Quatrième série, tome 76, n°30, 1978. pp. 273-282

Mitchell Salem Fisher, Robert Boyle, devout naturalist. A study in science and religion in the seventeenth century

Ladrière Jean. Mitchell Salem Fisher, Robert Boyle, devout naturalist. A study in science and religion in the seventeenth century. In: Revue Philosophique de Louvain. Troisième série, tome 45, n°8, 1947. pp. 399-402

La philosophie des mathématiques et le problème du formalisme

Ladrière Jean. La philosophie des mathématiques et le problème du formalisme. In: Revue Philosophique de Louvain. Troisième série, tome 57, n°56, 1959. pp. 600-622

Le 16e Congrès Mondial de Philosophie

Ladrière Jean. Le 16e Congrès Mondial de Philosophie. In: Revue Philosophique de Louvain. Quatrième série, tome 77, n°34, 1979. pp. 241-246

[Ultimate knowledge and the encounter with the ultimate. Religion and sciences]

The idea of a reciprocal exteriority between religion and science must be called into question from a more careful examination of the status of science. The understanding which is expressed in the body of the propositions recognised as "scientifically established" constitutes only a moment in a process, which has a provenance, in the form of a pre-understanding, and which aims at a state of thought which would be as a totalising vision. Scientific thinking is not totally separated from speculative thinking and this one intersects the cognitive component of religious experience. It is thus possible to recognise a positive affinity between scientific thinking, considered in its internal dynamism, and religious experience

Langage scientifique et langage spéculatif

Ladrière Jean. Langage scientifique et langage spéculatif . In: Revue Philosophique de Louvain. Quatrième série, tome 69, n°1, 1971. pp. 92-132