13 research outputs found
DIE GEBROCHENE DIMENSIONS ZAHL UND SEINE ANWENDUNG IN DER MIKROGEOMETRIE VON OBERFLÄCHEN IM MASCHINENBAU
The articIe demonstrates the generalized (fraction) dimension number and some
characteristic fractals as objects with fractional dimension. It gives the cIosed expression of the
dimension number according to Hausdorff, and the one of a simplified dimension number, which
is suitable for the global qualification ofthe machined surfaces. The illustrations are the product
of a self developed computer program
Dynamic manipulation of Bose-Einstein condensates with a spatial light modulator
We manipulate a Bose-Einstein condensate using the optical trap created by
the diffraction of a laser beam on a fast ferro-electric liquid crystal spatial
light modulator. The modulator acts as a phase grating which can generate
arbitrary diffraction patterns and be rapidly reconfigured at rates up to 1 kHz
to create smooth, time-varying optical potentials. The flexibility of the
device is demonstrated with our experimental results for splitting a
Bose-Einstein condensate and independently transporting the separate parts of
the atomic cloud.Comment: 4 pages, 4 figure
Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease.
Heat-shock protein 60 (Hsp60) has been shown to provoke inflammation, and anti-Hsp60 may facilitate the development of atherosclerosis. In this study, we have investigated 30 patients with mixed connective tissue disease (MCTD) and assessed anti-Hsp60 and their relationship to cardiovascular diseases (CVD). Out of 30 patients with MCTD, 15 had CVDs. Anti-Hsp60 antibody was determined by enzyme-linked immunosorbent assay. Since endothelial dysfunction and accelerated atherosclerosis are characteristic to MCTD, a wide array of MCTD-, endothelial dysfunction- and CVD-associated parameters was investigated: serum lipid levels, paraoxonase activity (PON1), rich nuclear ribonucleoprotein U1 (anti-U1RNP), anti-endothelial cell antibodies, anti-cardiolipin and anti-beta2-glycoprotein I antibody isotypes (anti-CL and anti-beta2GPI), endothelin-1 (ET-1) levels, also intima-media thickness (IMT), a quantitative indicator of atherosclerosis. In MCTD, anti-Hsp60 antibody levels were significantly higher than in healthy individuals (p < 0.02). MCTD patients with CVD had significantly higher levels of anti-Hsp60 compared to MCTD without CVD (p = 0.001). Patients with MCTD had significantly lower high-density lipoprotein cholesterol (p = 0.02) and PON activity (p < 0.001), and significantly increased systolic (p < 0.0002) and diastolic (p < 0.001) blood pressure compared to healthy individuals. Anti-U1RNP levels (p < 0.002) and IMT were higher in patients compared to controls (p = 0.002). The CVD-positive MCTD patients had increased anti-Hsp60 (p < 0.0013), anti-CL IgG (p = 0.0005), ET-1 serum concentration (p < 0.05) and IMT levels (p < 0.001) compared to MCTD patients without CVD. Anti-Hsp60 showed a strong correlation with anti-oxLDL (r = 0.36, p = 0.01) and serum ET-1 (r = 0.62, p < 0.001) and negative correlation with PON activity (r = -0.47, p = 0.01). Anti-Hsp60 indicates endothelial injury, CVD, and can function as a novel atherosclerotic risk factor, also a valuable diagnostic marker in patients with MCTD