Atypical localization of Eph-RTKs in childhood cancer rhabdomyosarcoma

Rhabdomyosarcoma (RMS), the most common soft tissue tumor in children, is an aggressive cancer with a 5-year survival rate of 24% if it has metastasized. Current treatment options are limited to surgery, chemotherapy and radiation, so there is a significant unmet need for targeted therapies. Eph receptor tyrosine kinases have been implicated in the development and progression of many other tumor types. Recent results from our group identified several Eph receptors expressed by primary muscle stem cells (satellite cells), which led us to screen for protein expression of Ephs in canine RMS primary tumors as well as mouse and human RMS cell lines. Intriguingly, we noted strong expression but abnormal localization of one Eph receptor: in multiple tumors from all three species, we detected EphA1 in the nucleus of interphase cells. Mislocalization of RTKs to the nucleus in other tumor types has been shown to promote cancer progression, with the classic case being ErbBs. There are only two published studies about Ephs localizing to the nucleus and to date no other nuclear RTKs have been identified in RMS. These data represent the first case of a nuclear RTK in RMS, and the first time that EphA1 has been detected in the nucleus of any cell type.Includes bibliographical reference

Facteurs associés à la poursuite de l'allaitement maternel jusqu'à six mois de vie de l'enfant : rôle des interactions mère-enfant, de la dépression postnatale et du tempérament de l'enfant

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal

Les archives dans l'art de Robert Rauschenberg

Ce mémoire adopte une perspective archivistique afin d'examiner l'art de Robert Rauschenberg, un artiste américain ayant fait ses débuts sur la scène artistique new-yorkaise des années soixante. Il est pertinent de voir les stratégies d’appropriation des artistes des années soixante, dont faisait partie Rauschenberg, comme ayant « mis la table » pour le mouvement des artistes allant puiser dans les archives pour leur pratique artistique, mouvement qui s'est développé depuis la fin des années quatre-vingt et le début des années quatre-vingt-dix. L'ensemble des rapports de l'artiste avec les archives est d'abord étudié. Ensuite, une lecture archivistique d'un corpus d'oeuvres est réalisée afin de mieux comprendre les particularités de l'utilisation des archives par Rauschenberg. Les conditions d'utilisation des archives sont relevées ainsi que la conception des archives comme mémoire, pour se terminer avec les rapports entre les archives et la photographie.This thesis takes an archival perspective in order to examine the work of Robert Rauschenberg, an American artist who gained notoriety in the New-York art scene of the sixties. It is relevant to see appropriation art strategies by artists like Rauschenberg as a way of having « set up the table » for the archival art movement that would follow, starting in the late eighties and early nineties. The artist's connexions with the archives are first studied. Then, an archival reading of a corpus of his artworks is conducted in order to learn about his particular use of the archives. The conditions of use are raised, along with the conception of archives as memory and, at last, the relationship between archives and photography

Étude du développement des lymphocytes T mémoires

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal

Complete Penile Necrosis in a Patient With Heparin-induced Thrombocytopenia: A Case Report

AbstractPenile necrosis is a rare condition that has been mostly described in association with diabetes mellitus and end-stage renal disease. We report an unusual case of acute penile necrosis because of heparin-induced thrombocytopenia. A 75-year-old man presented with acute renal failure and experienced cardiac complications during the hospitalization. The patient was treated twice with intravenous heparin. He developed symptoms of penile necrosis 4 days after the reintroduction of heparin. At that moment, the platelet count dropped by 61%, and the analysis of heparin-pf4 antibodies was positive for heparin-induced thrombocytopenia. The patient underwent a total penectomy and a perineal urethrostomy

Aide à la communication informatisée dans les TED

National audienceAprès avoir rappelé les symptômes de l'autisme comme pathologie neuro-développementale qui appartient aux Troubles Envahissants du Développement (TED), nous étudions les principes et les caractéristiques des supports visuels (classeurs traditionnels et tablettes électroniques) destinés aux enfants autistes afin qu'ils puissent communiquer avec leur entourage (famille et personnes chargées du suivi thérapeutique, éducatif ou pédagogique). Nous présentons les fonctionnalités d'un prototype innovant fonctionnant sur tablette électronique que nous avons développé (paramétrage des utilisateurs, du lexique, de la syntaxe des messages, mémorisation d'un journal des interactions, ...). Nous exposons les modalités de l'expérience que nous allons mener auprès de jeunes enfants autistes de moins de 6 ans dans le cadre de leur accueil au CATTP ISATIS (CH St-Jean-de Dieu) et dans leur cadre familial

Fault Zone Evolution and Development of a Structural and Hydrological Barrier: The Quartz Breccia in the Kiggavik Area (Nunavut, Canada) and Its Control on Uranium Mineralization

In the Kiggavik area (Nunavut, Canada), major fault zones along, or close to, where uranium deposits are found are often associated with occurrence of thick quartz breccia (QB) bodies. These bodies formed in an early stage (~1750 Ma) of the long-lasting tectonic history of the Archean basement, and of the Proterozoic Thelon basin. The main characteristics of the QB are addressed in this study; through field work, macro and microscopic observations, cathodoluminescence microscopy, trace elements, and oxygen isotopic signatures of the quartz forming the QB. Faults formed earlier during syn- to post-orogenic rifting (1850-1750 Ma) were subsequently reactivated, and underwent cycles of cataclasis, pervasive silicification, hydraulic brecciation, and quartz recrystallization. This was synchronous with the circulation of meteoric fluids mixing with Si-rich magmatic-derived fluids at depth, and were coeval with the emplacement of the Kivalliq igneous suite at 1750 Ma. These processes led to the emplacement of up to 30 m thick QB, which behaved as a mechanically strong, transverse hydraulic barrier that localized later fracturing, and compartmentalized/channelized vertical flow of uranium-bearing fluids after the deposition of the Thelon Basin (post 1750 Ma). The development and locations of QB control the location of uranium mineralization in the Kiggavik area

Functional changes in the cortical semantic network in amnestic mild cognitive impairment

Semantic memory impairment has been documented in older individuals with amnestic Mild cognitive impairment (aMCI), who are at risk of developing Alzheimer’s disease (AD), yet little is known about the neural basis of this breakdown. The main objective of this study was to investigate the brain mechanisms associated with semantic performance in patients with aMCI. Method: A group of aMCI patients and a group of healthy older controls carried out a semantic categorization task while their brain activity was recorded using magnetoencephalography (MEG). During the task, participants were shown famous faces and had to determine whether each famous person matched a given occupation. The main hypotheses were that: (i) semantic processing should be compromised for aMCI patients, and (ii) these deficits should be associated with cortical dysfunctions within specific areas of the semantic network. Results: Behavioural results showed that aMCI participants were significantly slower and less accurate than control participants at the semantic task, corroborating previous reports. Additionally, relative to controls, a significant pattern of hyperactivation was found in the aMCI group within specific regions of the semantic network, including the right anterior temporal lobe and inferior prefrontal cortex. Conclusions: Abnormal functional activation within key areas of the semantic network suggests that it is compromised early in the disease process. Moreover, this pattern of increased activation in aMCI was positively associated with grey matter integrity in specific areas, but was not associated with any specific pattern of atrophy, suggesting that functional hyperactivation may precede atrophy of the semantic network in aMCI