48 research outputs found
Evaluation of SHANSEP strenth-deformation properties of undisturbed Boston blue clay from automated triaxial testing
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1991.Includes bibliographical references (v. 1, leaves 250-252).by Axel Christian Luc Angliviel de La Beaumelle.M.S
3D mesh processing using GAMer 2 to enable reaction-diffusion simulations in realistic cellular geometries
Recent advances in electron microscopy have enabled the imaging of single
cells in 3D at nanometer length scale resolutions. An uncharted frontier for in
silico biology is the ability to simulate cellular processes using these
observed geometries. Enabling such simulations requires watertight meshing of
electron micrograph images into 3D volume meshes, which can then form the basis
of computer simulations of such processes using numerical techniques such as
the Finite Element Method. In this paper, we describe the use of our recently
rewritten mesh processing software, GAMer 2, to bridge the gap between poorly
conditioned meshes generated from segmented micrographs and boundary marked
tetrahedral meshes which are compatible with simulation. We demonstrate the
application of a workflow using GAMer 2 to a series of electron micrographs of
neuronal dendrite morphology explored at three different length scales and show
that the resulting meshes are suitable for finite element simulations. This
work is an important step towards making physical simulations of biological
processes in realistic geometries routine. Innovations in algorithms to
reconstruct and simulate cellular length scale phenomena based on emerging
structural data will enable realistic physical models and advance discovery at
the interface of geometry and cellular processes. We posit that a new frontier
at the intersection of computational technologies and single cell biology is
now open.Comment: 39 pages, 14 figures. High resolution figures and supplemental movies
available upon reques
Management of Road Infrastructure Safety
Road Infrastructure Safety Management (RISM) refers to a set of procedures that support a road authority in decision making related to the improvement of safety on a road network. Some of these procedures can be applied to existing infrastructure, thus enabling a reactive approach; and other procedures are used in early stages of a project's life-cycle allowing a proactive approach. The objective of this paper is to provide an overview of the most well-known procedures and present a series of recommendations for successful road infrastructure safety management. The work described in the paper was completed by the IRTAD sub-working group on Road Infrastructure Safety Management and presented in detail in the respective Report. The methodology followed on this purpose included the description of the most consolidated RISM procedures, the analysis of the use of RISM procedures worldwide and the identification of possible weaknesses and barriers to their implementation, the provision of good practice examples and the contribution to the scientific assessment of procedures. Specifically, the following RISM procedures were considered: Road Safety Impact Assessment (RIA), Efficiency Assessment Tools (EAT), Road Safety Audit (RSA), Network Operation (NO), Road Infrastructure Safety Performance Indicators (SPI), Network Safety Ranking (NSR), Road Assessment Programs (RAP), Road Safety Inspection (RSI), High Risk Sites (HRS) and In-depth Investigation. Each procedure was described along with tools and data needed for its implementation as well as relevant common practices worldwide. A synthesis summarizing the key information for each procedure was also drafted. Based on a survey on 23 IRTAD member countries from worldwide, the lack of resources or tools is the most commonly stated reason for not applying a RISM procedure. This has been frequently found mainly in European countries. Another common reason is the absence of recommendations/guidelines, especially for SPI, RAP, RSI and RSA. This highlights the importance of the presence of some legislation regulating the application of the procedures. Lack of data was found important mainly for SPI, HRS and EAT. Good practices of road infrastructure safety management have been explored in order to find solutions to the issues highlighted by the survey and provide examples about how these issues have been overcome in some countries. Specifically, issues related to data, legal framework, funding, knowledge, tools and dealing with more RISM procedures were addressed. Finally, nine key messages and six recommendations for better Road Infrastructure Safety Management were developed based on the conclusions made
From functional diversity to human well-being: A conceptual framework for agroecosystem sustainability
[EN] CONTEXT: Agricultural intensification contributes to global food security and well-being by supplying the food demand of a growing human population. However, ongoing land-use change and intensification seriously affect the abundance, diversity and distribution of species, besides many other impacts, thereby threatening the functioning of ecosystems worldwide. Despite the accumulating evidence that the current agricultural model is unsustainable, we are far from understanding the consequences of functional diversity loss for functioning and ecosystem service supply and the potential long-term threats to food security and human well-being.
OBJECTIVE: In this review, we propose a conceptual framework to understand the relationships between functional diversity and human well-being that also considers agroecosystem health. To this end, we identify the most commonly assumed relationships linking functional diversity to regulating and provisioning agroecosystem services and their importance for human well-being, emphasising the most serious knowledge gaps in the in-dividual pathways of the conceptual framework.
METHODS: A consortium formed by an international panel of experts from different disciplines including functional diversity, ecosystem services and human health compiled 275 articles. Members of the consortium proposed literature to exemplify each specific aspect of the conceptual framework in the text, in accordance with his/her field of expertise. The guideline for all experts was to focus mostly in current literature (38% of the references are from the last 5 years and 66% from the last decade), with special interest in reviews and synthesis articles (42% of the references), as well as meta-analyses and global studies (10% of the references).
RESULTS AND CONCLUSIONS: The factors that influence agroecosystem health are extremely complex, involving both services and disservices related to land-use management and environmental conditions. The global human population needs sustainable and resilient agroecosystems and a concerted effort is needed to fundamentally redesign agricultural practices to feed the growing human population without further jeopardising the quality of life for future generations. We highlight the potential effects of land-use change and ecological intensification on the functional diversity of plant and animal communities, and the resulting consequences for ecosystem services and ultimately human health.
SIGNIFICANCE: The resulting conceptual model is developed for researchers as well as policy makers high- lighting the need for a holistic approach to understand diversity impacts on human well-being. Finally, we document a major knowledge gap due to the lack of any studies focusing on the full pathway from diversity to human well-being.S
Die Antwort Des aus der Bastille befreyeten Anglivie de la Beaumelle an den Herrn von Voltaire auf dessen Svpplement Der Zeiten Ludewigs des XIV. / aus dem Französischen übersetzet mit einem Anhange zwoer sinnreichen Grab-Schriften, deren eine auf den Herrn von Voltaire und die andere auf die Marquise du Chastelet gemacht worden.
DIE ANTWORT DES AUS DER BASTILLE BEFREYETEN ANGLIVIE DE LA BEAUMELLE AN DEN HERRN VON VOLTAIRE AUF DESSEN SVPPLEMENT DER ZEITEN LUDEWIGS DES XIV. / AUS DEM FRANZÖSISCHEN ÜBERSETZET MIT EINEM ANHANGE ZWOER SINNREICHEN GRAB-SCHRIFTEN, DEREN EINE AUF DEN HERRN VON VOLTAIRE UND DIE ANDERE AUF DIE MARQUISE DU CHASTELET GEMACHT WORDEN.
Die Antwort Des aus der Bastille befreyeten Anglivie de la Beaumelle an den Herrn von Voltaire auf dessen Svpplement Der Zeiten Ludewigs des XIV. / aus dem Französischen übersetzet mit einem Anhange zwoer sinnreichen Grab-Schriften, deren eine auf den Herrn von Voltaire und die andere auf die Marquise du Chastelet gemacht worden. (1)
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La torture dans les Res Gestae d'Ammien Marcellin
Angliviel de la Beaumelle Laurent. La torture dans les Res Gestae d'Ammien Marcellin. In: Institutions, société et vie politique dans l'Empire romain au IVe siècle ap. J.-C. Actes de la table ronde autour de l'œuvre d'André Chastagnol (Paris, 20-21 janvier 1989) Rome : École Française de Rome, 1992. pp. 91-113. (Publications de l'École française de Rome, 159
Memoire De M. De Voltaire, Apostillé Par M. De La Beaumelle
Vorlageform des Erscheinungsvermerks: A Francfort, MDCCLIII