The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide

Objective. This study is to investigate the role of the CIKs cocultured with K-ras-DCs in killing of pancreatic cancer cell lines, PANC-1 (K-ras+) and SW1990 (K-ras−). Methods. CIKs induced by IFN-γ, IL-2, and anti-CD3 monoantibody, K-ras-DCCIKs obtained by cocultivation of k-ras-DCs and CIKs. Surface markers examined by FACS. IFN-γ IL-12 ,CCL19 and CCL22 detected by ELISA. Proliferation of various CIKs tested via 3H-TdR. Killing activities of k-ras-DCCIKs and CTLs examined with 125IUdR. Results. CD3+CD56+ and CD3+CD8+ were highly expressed by K-ras-DCCIKs. In its supernatant, IFN-γ, IL-12, CCL19 and CCL22 were significantly higher than those in DCCIK and CIK. The killing rate of K-ras-DCCIK was greater than those of CIK and CTL. CTL induced by K-ras-DCs only inhibited the PANC-1 cells. Conclusions. The k-ras-DC can enhance CIK's proliferation and increase the killing effect on pancreatic cancer cell. The CTLs induced by K-ras-DC can only inhibit PANC-1 cells. In this study, K-ras-DCCIKs also show the specific inhibition to PANC-1 cells, their tumor suppression is almost same with the CTLs, their total tumor inhibitory efficiency is higher than that of the CTLs

Generalized radio resource management for overlapping MBS zones

Multicast and broadcast service (MBS) is a point-to-multipoint service where data packets are transmitted simultaneously from a single source to multiple destinations. In MBS, some base stations (BSs) may form an MBS zone and transmit identical MBS contents simultaneously using the same modulation and coding scheme. Hence, the network has to coordinate the transmission of BSs such that BSs belonging to multiple MBS zones may utilize non-conflict resources to transmit different MBS contents. This paper extends the work in [10] for accommodating MBS zones with different service presence probabilities and various bandwidth requirements. A continuous allocation algorithm and a non-continuous allocation algorithm are presented to allocate resource units for overlapping MBS zones. Simulations were conducted to verify the effectiveness of the proposed algorithms

Experimental Trapped-ion Quantum Simulation of the Kibble-Zurek dynamics in momentum space

The Kibble-Zurek mechanism is the paradigm to account for the nonadiabatic dynamics of a system across a continuous phase transition. Its study in the quantum regime is hindered by the requisite of ground state cooling. We report the experimental quantum simulation of critical dynamics in the transverse-field Ising model by a set of Landau-Zener crossings in pseudo-momentum space, that can be probed with high accuracy using a single trapped ion. We test the Kibble-Zurek mechanism in the quantum regime in the momentum space and find the measured scaling of excitations is in accordance with the theoretical prediction.Comment: 10 pages, 3 figures Published in Scientific Reports, http://www.nature.com/articles/srep3338

Four new isoflavanones from Tadehagi triquetrum

Four new isoflavanones with isoprenoid units, named triquetrumones E-H (1–4), were isolated from the whole plants of Tadehagi triquetrum. The structures were elucidated on the basis of spectroscopic analyses, including application of MS, UV, IR, 1D and 2D NMR spectroscopic techniques. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0033-5 and is accessible for authorized users

Cold hybrid electrical-optical ion trap

Advances in research such as quantum information and quantum chemistry require subtle methods for trapping particles (including ions, neutral atoms, molecules, etc.). Here we propose a hybrid ion trapping method by combining a Paul trap with optical tweezers. The trap combines the advances of the deep-potential feature for the Paul trap and the micromotion-free feature for the optical dipole trap. By modulating the optical-dipole trap synchronously with the radio frequency voltage of the Paul trap, the alternating electrical force in the trap center is fully counteracted, and the micromotion temperature of a cold trapped ion can reach the order of nK while the trap depth is beyond 300K. These features will enable cold collisions between an ion and an atom in the $s$-wave regime and stably trap the produced molecular ion in the cold hybrid system. This will provide a unique platform for probing the interactions between the ions and the surrounding neutral particles and enable the investigation of new reaction pathways and reaction products in the cold regime

Quantumness and quantum to classical transition in the generalized Rabi model

The quantum to classical transition (QCT) is one of the central mysteries in quantum physics. This process is generally interpreted as state collapse from measurement or decoherence from interacting with the environment. Here we define the quantumness of a Hamiltonian by the free energy difference between its quantum and classical descriptions, which vanishes during QCT. We apply this criterion to the many-body Rabi model and study its scaling law across the phase transition, finding that not only the temperature and Planck constant, but also all the model parameters are important for this transition. We show that the Jaynes-Cummings and anti Jaynes-Cummings models exhibit greater quantumness than the Rabi model. Moreover, we show that the rotating wave and anti-rotating wave terms in this model have opposite quantumness in QCT. We demonstrate that the quantumness may be enhanced or suppressed at the critical point. Finally, we estimate the quantumness of the Rabi model in current trapped ion experiments. The quantumness provides an important tool to characterize the QCT in a vast number of many-body models.Comment: 6 pages, 5 figure

Magnon-bandgap controllable artificial domain wall waveguide

In this paper, a magnon-bandgap controllable artificial domain wall waveguide is proposed by means of micromagnetic simulation. By the investigation of the propagation behavior and dispersion relationship of spin waves in artificial domain wall waveguides, it is found that the nonreciprocal propagation of spin waves in the artificial domain walls are mainly affected by the local effective exchange field, and the magnon bandgap can be controlled by changing the maximum value of the effective exchange field. In addition, it is observed that the artificial domain wall waveguides are structurally more stable than the natural domain wall waveguides under the same spin wave injection conditions, and the magnon bandgap of the artificial domain wall waveguides can be adjusted by its width and magnetic anisotropy parameters. The bandgap controllable artificial domain wall scheme is beneficial to the miniaturization and integration of magnon devices and can be applied to future magnonic technology as a novel frequency filter

预处理对多孔硅形成过程的影响

【Abstract】In this work, effect of precondition on porous silicon formation was investigated by performing electrochemical polarization measurements. The surface morphologies and optical properties of the samples were also studied by scanning electron microscopy (SEM) and Raman spectrometer. It was demonstrated that precondition enhanced the chemical/electrochemical reactions occurred at Si/solution interface and the growth of porous silicon, which ultimately resulted in a red shift in photoluminescence. However, the thickness of porous silicon decreased with the increase of precondition time. More broad bands were observed with prolonged precondition.【中文摘要】本工作初步探讨了开路电位下对硅片进行预处理时多孔硅的形成过程 .电化学极化实验、扫描电镜和拉曼谱学的研究表明 ,预处理可以加速硅 /溶液界面上的化学或电化学反应 ,从而加快多孔硅的生长过程 ,最终导致光致发光的光谱红移 .多孔硅的厚度随预处理时间的增长而减