Synthetic clock transitions via continuous dynamical decoupling

Decoherence of quantum systems due to uncontrolled fluctuations of the environment presents fundamental obstacles in quantum science. `Clock' transitions which are insensitive to such fluctuations are used to improve coherence, however, they are not present in all systems or for arbitrary system parameters. Here, we create a trio of synthetic clock transitions using continuous dynamical decoupling in a spin-1 Bose-Einstein condensate in which we observe a reduction of sensitivity to magnetic field noise of up to four orders of magnitude; this work complements the parallel work by Anderson et al. (submitted, 2017). In addition, using a concatenated scheme, we demonstrate suppression of sensitivity to fluctuations in our control fields. These field-insensitive states represent an ideal foundation for the next generation of cold atom experiments focused on fragile many-body phases relevant to quantum magnetism, artificial gauge fields, and topological matter.Comment: 8 pages, 4 figures, Supplemental material

Repeated Measurements with Minimally Destructive Partial-Transfer Absorption Imaging

We demonstrate partial-transfer absorption imaging as a technique for repeatedly imaging an ultracold atomic ensemble with minimal perturbation. We prepare an atomic cloud in a state that is dark to the imaging light. We then use a microwave pulse to coherently transfer a small fraction of the ensemble to a bright state, which we image using in situ absorption imaging. The amplitude or duration of the microwave pulse controls the fractional transfer from the dark to the bright state. For small transfer fractions, we can image the atomic cloud up to 50 times before it is depleted. As a sample application, we repeatedly image an atomic cloud oscillating in a dipole trap to measure the trap frequency

Repeated Measurements with Minimally Destructive Partial-Transfer Absorption Imaging

We demonstrate partial-transfer absorption imaging as a technique for repeatedly imaging an ultracold atomic ensemble with minimal perturbation. We prepare an atomic cloud in a state that is dark to the imaging light. We then use a microwave pulse to coherently transfer a small fraction of the ensemble to a bright state, which we image using in situ absorption imaging. The amplitude or duration of the microwave pulse controls the fractional transfer from the dark to the bright state. For small transfer fractions, we can image the atomic cloud up to 50 times before it is depleted. As a sample application, we repeatedly image an atomic cloud oscillating in a dipole trap to measure the trap frequency.Comment: 12 pages, 7 figure

Atoms in a radiofrequency-dressed optical lattice

We load cold atoms into an optical lattice dramatically reshaped by radiofrequency (rf) coupling of state-dependent lattice potentials. This rf dressing changes the unit cell of the lattice at a subwavelength scale, such that its curvature and topology departs strongly from that of a simple sinusoidal lattice potential. Radiofrequency dressing has previously been performed at length scales from mm to tens of microns, but not at the single-optical-wavelength scale. At this length scale significant coupling between adiabatic potentials leads to nonadiabatic transitions, which we measure as a function of lattice depth and dressing frequency and amplitude. We also investigate the dressing by measuring changes in the momentum distribution of the dressed states.Comment: 5 pages, 4 figure

The Endogenous Th17 Response in NO<inf>2</inf>-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. © 2013 Martin et al

Observation of ultracold atomic bubbles in orbital microgravity

Substantial leaps in the understanding of quantum systems have been driven by exploring geometry, topology, dimensionality and interactions in ultracold atomic ensembles1–6. A system where atoms evolve while confined on an ellipsoidal surface represents a heretofore unexplored geometry and topology. Realizing an ultracold bubble—potentially Bose–Einstein condensed—relates to areas of interest including quantized-vortex flow constrained to a closed surface topology, collective modes and self-interference via bubble expansion7–17. Large ultracold bubbles, created by inflating smaller condensates, directly tie into Hubble-analogue expansion physics18–20. Here we report observations from the NASA Cold Atom Lab21 facility onboard the International Space Station of bubbles of ultracold atoms created using a radiofrequency-dressing protocol. We observe bubble configurations of varying size and initial temperature, and explore bubble thermodynamics, demonstrating substantial cooling associated with inflation. We achieve partial coverings of bubble traps greater than one millimetre in size with ultracold films of inferred few-micrometre thickness, and we observe the dynamics of shell structures projected into free-evolving harmonic confinement. The observations are among the first measurements made with ultracold atoms in space, using perpetual freefall to explore quantum systems that are prohibitively difficult to create on Earth. This work heralds future studies (in orbital microgravity) of the Bose–Einstein condensed bubble, the character of its excitations and the role of topology in its evolution

Field-sensitive addressing and control of field-insensitive neutral-atom qubits

The establishment of a scalable scheme for quantum computing with addressable and long-lived qubits would be a scientific watershed, harnessing the laws of quantum physics to solve classically intractable problems. The design of many proposed quantum computational platforms is driven by competing needs: isolating the quantum system from the environment to prevent decoherence, and easily and accurately controlling the system with external fields. For example, neutral-atom optical-lattice architectures provide environmental isolation through the use of states that are robust against fluctuating external fields, yet external fields are essential for qubit addressing. Here we demonstrate the selection of individual qubits with external fields, despite the fact that the qubits are in field-insensitive superpositions. We use a spatially inhomogeneous external field to map selected qubits to a different field-insensitive superposition ("optical MRI"), minimally perturbing unselected qubits, despite the fact that the addressing field is not spatially localized. We show robust single-qubit rotations on neutral-atom qubits located at selected lattice sites. This precise coherent control is an important step forward for lattice-based neutral-atom quantum computation, and is quite generally applicable to state transfer and qubit isolation in other architectures using field-insensitive qubits.Comment: press embarg

The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice

The inflammatory cytokine TNF-alpha is a central mediator in many immune-mediated diseases, such as Crohn's disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD). Epidemiologic studies have shown that cigarette smoking (CS) is a prominent common risk factor in these TNF-dependent diseases. We exposed TNF Delta ARE mice; in which a systemic TNF-alpha overexpression leads to the development of inflammation; to 2 or 4 weeks of air or CS. We investigated the effect of deregulated TNF expression on CS-induced pulmonary inflammation and the effect of CS exposure on the initiation and progression of gut and joint inflammation. Upon 2 weeks of CS exposure, inflammation in lungs of TNF Delta ARE mice was significantly aggravated. However, upon 4 weeks of CS-exposure, this aggravation was no longer observed. TNF Delta ARE mice have no increases in CD4+ and CD8+ T cells and a diminished neutrophil response in the lungs after 4 weeks of CS exposure. In the gut and joints of TNF Delta ARE mice, 2 or 4 weeks of CS exposure did not modulate the development of inflammation. In conclusion, CS exposure does not modulate gut and joint inflammation in TNF Delta ARE mice. The lung responses towards CS in TNF Delta ARE mice however depend on the duration of CS exposure

Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX.

We have independently isolated and characterized cDNA and genomic clones for the human coagulation factor IX. Sequence analysis in both cases indicates that threonine is encoded by the triplet ACT as the third residue of the activation peptide. This is in agreement with some earlier reports but in disagreement with others that show the alanine triplet GCT at this position. The discrepancy can thus be accounted for by natural variation of a single nucleotide in the normal population. Amino acid sequence analyses of activated factor IX from plasma samples of four individuals yielded two cases of alanine and two cases of threonine at the third position of the activation peptide. In factor IX from pooled plasma and in factor IX from a heterozygous individual, however, both alanine and threonine were found. Taken together, the findings show that a prevalent nondeleterious dimorphism exists in the activation peptide of human coagulation factor IX

Localization of telomeres and telomere-associated proteins in telomerase-negative Saccharomyces cerevisiae

Cells lacking telomerase cannot maintain their telomeres and undergo a telomere erosion phase leading to senescence and crisis in which most cells become nonviable. On rare occasions survivors emerge from these cultures that maintain their telomeres in alternative ways. The movement of five marked telomeres in Saccharomyces cerevisiae was followed in wild-type cells and through erosion, senescence/crisis and eventual survival in telomerase-negative (est2::HYG) yeast cells. It was found that during erosion, movements of telomeres in est2::HYG cells were indistinguishable from wild-type telomere movements. At senescence/crisis, however, most cells were in G2 arrest and the nucleus and telomeres traversed back and forth across the bud neck, presumably until cell death. Type I survivors, using subtelomeric Y′ amplification for telomere maintenance, continued to show this aberrant telomere movement. However, Type II survivors, maintaining telomeres by a sudden elongation of the telomere repeats, became indistinguishable from wild-type cells, consistent with growth properties of the two types of survivors. When telomere-associated proteins Sir2p, Sir3p and Rap1p were tagged, the same general trend was seen—Type I survivors retained the senescence/crisis state of protein localization, while Type II survivors were restored to wild type