News from Academy Bay

New Faces and New Projects in a New CDRS Department. International Workshop: Feral Goat Eradication Program. Geologists to Invade Galápagos. GIS in Galápagos. The Isabela Project: Off and Running. A Pig-Free Santiago: Is it a Dream or on the Horizon? The Special Law for Galápagos

La lógica en la investigación académica

All research work has a reasoning process. This process begins with the most elementary logic of our human nature. But then this reasoning deepens when we turn to logic as a discipline. Whoever is in charge of imparting this knowledge to us is a logic teacher, who, in addition to knowing logic, must know how to transmit his knowledge, must teach with logic. This happens in a similar way with a teacher of any subject, discipline or skill. Any teacher must teach with logic. Teaching with logic is teaching with coherence in the context of demonstration, contrast, or verification. Teaching with logic is showing that all research has an explanatory sequence; it is to give reasons, foundations about an idea that is being defended. In the world of academic research, a thesis involves a demonstration process, which is born in the same research project. The process of building a thesis project implies a strictly logical background.Todo trabajo de investigación tiene un proceso de razonamiento. Este proceso se inicia con la lógica más elemental de nuestra naturaleza humana. Pero luego este razonamiento se hace más profundo cuando recurrimos a la lógica como disciplina. Quien se encarga de impartirnos estos conocimientos es un profesor de lógica, quien, además de saber lógica, debe saber transmitir sus conocimientos, debe enseñar con lógica. Esto sucede de manera similar con un profesor de cualquier asignatura, disciplina o habilidad. Cualquier profesor debe enseñar con lógica. Enseñar con lógica es enseñar con coherencia en el contexto de la demostración, contrastación o verificación. Enseñar con lógica es mostrar que toda investigación tiene una secuencia explicativa; es dar razones, fundamentos sobre una idea que se está defendiendo. En el mundo de la investigación académica, una tesis implica un proceso de demostración, el cual nace en el mismo proyecto de investigación. El proceso de construcción de un proyecto de tesis implica un trasfondo netamente lógico

Amyloid precursor protein processing in human neurons with an allelic series of the PSEN1 intron 4 deletion mutation and total presenilin-1 knockout

Mutations in presenilin-1 (PSEN1), encoding the catalytic subunit of the amyloid precursor protein-processing enzyme γ-secretase, cause familial Alzheimer’s disease. However, the mechanism of disease is yet to be fully understood and it remains contentious whether mutations exert their effects predominantly through gain or loss of function. To address this question, we generated an isogenic allelic series for the PSEN1 mutation intron 4 deletion; represented by control, heterozygous and homozygous mutant induced pluripotent stem cells in addition to a presenilin-1 knockout line. Induced pluripotent stem cell-derived cortical neurons reveal reduced, yet detectable amyloid-beta levels in the presenilin-1 knockout line, and a mutant gene dosage-dependent defect in amyloid precursor protein processing in PSEN1 intron 4 deletion lines, consistent with reduced processivity of γ-secretase. The different effects of presenilin-1 knockout and the PSEN1 intron 4 deletion mutation on amyloid precursor protein-C99 fragment accumulation, nicastrin maturation and amyloid-beta peptide generation support distinct consequences of familial Alzheimer’s disease-associated mutations and knockout of presenilin-1 on the function of γ-secretase

Decontamination of Diesel particles from air by using the Counterfog (R) system

The existence of particles with diameter under 10m in air is strongly correlated with respiratory diseases. These particles are profusely produced by heating systems, traffic, and Diesel engines creating a serious problem to modern cities. Natural mechanisms removing particles from the atmosphere are too slow to deal with the huge amount of particles daily released by human activity. The objective of this work is to measure the effectiveness of a new technology called Counterfog (R) to eliminate airborne particles. The results show that Counterfog (R) is able to wash out PM10, PM5, and PM2.5 Diesel-generated airborne particles quite efficiently.This work has been funded by the FP7-SEC-2012-1 program of the EU Commission under grant number 312804

Ionized gas kinematics and chemical abundances of low-mass star-forming galaxies at z∼3z\sim 3

We selected 35 low-mass SFGs (7.9<log(M$_*$/M$_{\odot}$)<10.3) from deep spectroscopic surveys based on their CIII]1908 emission. We used follow-up NIR observations to examine their rest-optical emission lines and identify ionized outflow signatures through broad emission wings detected after Gaussian modeling of [OIII]4959,5007 profiles. We characterized the galaxies' gas-phase metallicity and carbon-to-oxygen (C/O) abundance using a Te-based method via the OIII]1666/[OIII]5007 ratio and photoionization models. We find line ratios and rest-frame EWs characteristic of high-ionization conditions powered by massive stars. Our sample displays mean rest-frame EW([OIII]5007)~560\r{A} while 15% of them show EW([OIII]4959,5007)>1000\r{A} and EW(CIII])>5\r{A}, closely resembling those now seen in EoR galaxies with JWST. We find low gas-phase metallicities 12+log(O/H)~7.5-8.5 and C/O abundances from 23%-128% solar, with no apparent increasing trend with metallicity. From our [OIII]4959,5007 profile modeling, we find that 65% of our sample shows an outflow component, which is shifted relative to the ionized gas systemic velocity, with mean $v_{max}$~280 km/s which correlates with the $\Sigma_{SFR}$. We find that the mass-loading factor $\mu$ of our sample is typically lower than in more massive galaxies from literature but higher than in typical local dwarf galaxies. In the stellar mass range covered, we find that $\mu$ increases with $\Sigma_{SFR}$ thus suggesting that for a given stellar mass, denser starbursts in low-mass galaxies produce stronger outflows. Our results complement the picture drawn by similar studies at lower redshift, suggesting that the removal of ionized gas in low-mass SFGs driven by stellar feedback is regulated by their stellar mass and by the strength and concentration of their star formation, i.e. $\Sigma_{\rm SFR}$.Comment: Accepted for publication in A&A. We updated the manuscript following referee's suggestions. We updated the estimations of C/O by not including CIV flux since it is not detected in most of our sample. No major changes in our results compared with previous versio

Virtual reality and augmented reality as strategies for teaching social skills to individuals with intellectual disability: a systematic review

Virtual reality (VR) and augmented reality (AR) programs have proliferated significantly in recent years and they are finding their way into different educational and therapeutic purposes. This systematic review aims at analyzing the virtual reality and augmented reality programs designed to promote the development of social skills in individuals with intellectual disability. Searches were carried out in the Scopus, Science Direct, Springer and Web of Science databases in the period from 2005 to 2020. A total of six articles met the inclusion criteria. A descriptive data analysis was performed. The results show that the clinical profile of the individuals who participated in the interventions is diverse. It can be concluded that there is some scientific evidence that points to the usefulness of VR and AR in the development of intervention programs to improve the social skills of individuals diagnosed with developmental deficits. However, it is necessary to acknowledge methodological limitations such as the lack of control groups, follow-up measures and of generalization of the resultsAgencia Nacional de Investigación e Innovació

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the metabolism of SSRIs, thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide dosing recommendations for fluvoxamine, paroxetine, citalopram, escitalopram, and sertraline based on CYP2D6 and/or CYP2C19 genotype (updates at www.pharmgkb.org)