Interacting universes and the cosmological constant

We study some collective phenomena that may happen in a multiverse scenario. First, it is posed an interaction scheme between universes whose evolution is dominated by a cosmological constant. As a result of the interaction, the value of the cosmological constant of one of the universes becomes very close to zero at the expense of an increasing value of the cosmological constant of the partner universe. Second, we found normal modes for a 'chain' of interacting universes. The energy spectrum of the multiverse, being this taken as a collective system, splits into a large number of levels, some of which correspond to a value of the cosmological constant very close to zero. We finally point out that the multiverse may be much more than the mere sum of its parts.Comment: 7 page

Microbe-mediated alterations in floral nectar: consequences for insect parasitoids

Floral nectar is frequently colonized by microbes among which bacteria and yeasts are the most abundant. These microbes have the ability to alter nectar characteristics with consequences for the whole community of flower-visiting insects. Recent research carried out on natural enemies of insect herbivores has shown that microbe-mediated changes in nectar traits can influence the foraging behavior and life history traits of parasitoids. The production of microbial volatile organic compounds can affect the attraction of parasitoids to nectar, while changes in sugar and amino acid composition can impact their longevity. Future research should focus on understanding the effects of nectar microbial colonization on parasitoid reproduction, with a specific emphasis on the interactions among different microbial taxa known to co-occur in floral nectar. Overall, this review highlights the importance of considering the role of nectar-inhabiting microbes in shaping the interactions between parasitoids and their food resources

Genetic characterization of Pepino mosaic virus isolates from Belgian greenhouse tomatoes reveals genetic recombination

Over a period of a few years, Pepino mosaic virus (PepMV) has become one of the most important viral diseases in tomato production worldwide. Infection by PepMV can cause a broad range of symptoms on tomato plants, often leading to significant financial losses. At present, five PepMV genotypes (EU, LP, CH2, US1 and US2) have been described, three of which (EU, LP and US2) have been reported in Europe. Thus far, no correlation has been found between different PepMV genotypes and the symptoms expressed in infected plants. In this paper, the genetic diversity of the PepMV population in Belgian greenhouses is studied and related to symptom development in tomato crops. A novel assay based on restriction fragment length polymorphism (RFLP) was developed to discriminate between the different PepMV genotypes. Both RFLP and sequence analysis revealed the occurrence of two genotypes, the EU genotype and the CH2 genotype, within tomato production in Belgium. Whereas no differences were observed in symptom expression between plants infected by one of the two genotypes, co-infection with both genotypes resulted in more severe PepMV symptoms. Furthermore, our study revealed that PepMV recombinants frequently occur in mixed infections under natural conditions. This may possibly result in the generation of viral variants with increased aggressivenes

Does virulence assessment of Vibrio anguillarum using sea bass (Dicentrarchus labrax) larvae correspond with genotypic and phenotypic characterization?

Background: Vibriosis is one of the most ubiquitous fish diseases caused by bacteria belonging to the genus Vibrio such as Vibrio (Listonella) anguillarum. Despite a lot of research efforts, the virulence factors and mechanism of V. anguillarum are still insufficiently known, in part because of the lack of standardized virulence assays. Methodology/Principal Findings: We investigated and compared the virulence of 15 V. anguillarum strains obtained from different hosts or non-host niches using a standardized gnotobiotic bioassay with European sea bass (Dicentrarchus labrax L.) larvae as model hosts. In addition, to assess potential relationships between virulence and genotypic and phenotypic characteristics, the strains were characterized by random amplified polymorphic DNA (RAPD) and repetitive extragenic palindromic PCR (rep-PCR) analyses, as well as by phenotypic analyses using Biolog's Phenotype MicroArray (TM) technology and some virulence factor assays. Conclusions/Significance: Virulence testing revealed ten virulent and five avirulent strains. While some relation could be established between serotype, genotype and phenotype, no relation was found between virulence and genotypic or phenotypic characteristics, illustrating the complexity of V. anguillarum virulence. Moreover, the standardized gnotobiotic system used in this study has proven its strength as a model to assess and compare the virulence of different V. anguillarum strains in vivo. In this way, the bioassay contributes to the study of mechanisms underlying virulence in V. anguillarum

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination may contribute to malignant transformation. Here, we identified the de-ubiquitinase OTUB1 as a negative regulator of RAS mono- and di-ubiquitination. OTUB1 inhibits RAS ubiquitination independently of its catalytic activity resulting in sequestration of RAS on the plasma membrane. OTUB1 promotes RAS activation and tumorigenesis in wild-type RAS cells. An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 phosphorylation, high Ki67 score, and poorer patient survival. Our results strongly indicate that dysregulation of RAS ubiquitination represents an alternative mechanism of RAS activation during lung cancer development

Parafermionic algebras, their modules and cohomologies

We explore the Fock spaces of the parafermionic algebra introduced by H.S. Green. Each parafermionic Fock space allows for a free minimal resolution by graded modules of the graded 2-step nilpotent subalgebra of the parafermionic creation operators. Such a free resolution is constructed with the help of a classical Kostant's theorem computing Lie algebra cohomologies of the nilpotent subalgebra with values in the parafermionic Fock space. The Euler-Poincar\'e characteristics of the parafermionic Fock space free resolution yields some interesting identities between Schur polynomials. Finally we briefly comment on parabosonic and general parastatistics Fock spaces.Comment: 10 pages, talk presented at the International Workshop "Lie theory and its applications in Physics" (17-23 June 2013, Varna, Bulgaria