On the crossing relation in the presence of defects

The OPE of local operators in the presence of defect lines is considered both in the rational CFT and the $c>25$ Virasoro (Liouville) theory. The duality transformation of the 4-point function with inserted defect operators is explicitly computed. The two channels of the correlator reproduce the expectation values of the Wilson and 't Hooft operators, recently discussed in Liouville theory in relation to the AGT conjecture.Comment: TEX file with harvmac; v3: JHEP versio

The Virtue of Defects in 4D Gauge Theories and 2D CFTs

We advance a correspondence between the topological defect operators in Liouville and Toda conformal field theories - which we construct - and loop operators and domain wall operators in four dimensional N=2 supersymmetric gauge theories on S^4. Our computation of the correlation functions in Liouville/Toda theory in the presence of topological defect operators, which are supported on curves on the Riemann surface, yields the exact answer for the partition function of four dimensional gauge theories in the presence of various walls and loop operators; results which we can quantitatively substantiate with an independent gauge theory analysis. As an interesting outcome of this work for two dimensional conformal field theories, we prove that topological defect operators and the Verlinde loop operators are different descriptions of the same operators.Comment: 59 pages, latex; v2 corrections to some formula

't Hooft Operators in Gauge Theory from Toda CFT

We construct loop operators in two dimensional Toda CFT and calculate with them the exact expectation value of certain supersymmetric 't Hooft and dyonic loop operators in four dimensional \Ncal=2 gauge theories with SU(N) gauge group. Explicit formulae for 't Hooft and dyonic operators in \Ncal=2^* and \Ncal=2 conformal SQCD with SU(N) gauge group are presented. We also briefly speculate on the Toda CFT realization of arbitrary loop operators in these gauge theories in terms of topological web operators in Toda CFT.Comment: 49 pages, LaTeX. Typos fixed, references adde

Is a ‘new feminist visibility’ emerging in the UK PR industry? Senior women’s discourse and performativity within the neoliberal PR firm

Despite persistent gender inequalities, the Public Relations (PR) industry in the UK has historically reflected unease with feminism (Yaxley, 2013; L'Etang, 2015). However, indications of a ‘new feminist visibility’ raise significant questions. Do these feminist moves reflect a blossoming of feminist practice in the PR industry? Or rather, in an occupation that is strongly intertwined with neoliberalism and promotional culture (Miller and Dinan, 2000; Cronin, 2018), is the PR industry emblematic of a highly individualised ‘neoliberal feminism’ (Rottenberg, 2014) and a postfeminist sensibility in which ‘multiple and contradictory ideas’ co-exist? (Gill, 2016: 622). Adopting Edley’s (2000) discourse analysis framework, data drawn from interviews with seven senior female practitioners, supported by observational data, was critically explored in relation to literature in gender sociology, cultural studies and feminist literature in PR. While the online presence of women’s networks in PR provide evidence of a feminist visibility to address inequalities, the ‘subject positions’ and ‘interpretative repertoires’ in the data were characteristic of neoliberal feminist individualism that calls upon women to provide for their own needs and aspirations through ‘self help’ measures. Further, while sex discrimination in the PR industry featured prominently within the discursive repertoires of some participants, inequalities in everyday agency practice were either left unchallenged in response to client expectations or tackled through individual actions. Contradictory repertoires, including the repudiation of sexism, were indicative of entrepreneurial discourse (Lewis, 2006) and a postfeminist sensibility (Gill et al, 2017). Senior PR women providing client services appear to have limited scope beyond individualised, performative strategies to challenge the structures that perpetuate inequalities in PR and bring about transformative change (Golombisky, 2015). Although findings are limited to a small-scale study, this paper contributes a unique perspective of the intersections between neoliberalism, third wave feminism, postfeminism and performativity within the UK PR industry. Keywords: Neoliberalism, postfeminism, performativity, discourse, women, public relations agencie

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

A Mouse Model for Osseous Heteroplasia

GNAS/Gnas encodes Gsa that is mainly biallelically expressed but shows imprinted expression in some tissues. In Albright Hereditary Osteodystrophy (AHO) heterozygous loss of function mutations of GNAS can result in ectopic ossification that tends to be superficial and attributable to haploinsufficiency of biallelically expressed Gsa. Oed-Sml is a point missense mutation in exon 6 of the orthologous mouse locus Gnas. We report here both the late onset ossification and occurrence of benign cutaneous fibroepithelial polyps in Oed-Sml. These phenotypes are seen on both maternal and paternal inheritance of the mutant allele and are therefore due to an effect on biallelically expressed Gsa. The ossification is confined to subcutaneous tissues and so resembles the ossification observed with AHO. Our mouse model is the first with both subcutaneous ossification and fibroepithelial polyps related to Gsa deficiency. It is also the first mouse model described with a clinically relevant phenotype associated with a point mutation in Gsa and may be useful in investigations of the mechanisms of heterotopic bone formation. Together with earlier results, our findings indicate that Gsa signalling pathways play a vital role in repressing ectopic bone formation