Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration

The REMARK “elaboration and explanation” guideline, by Doug Altman and colleagues, provides a detailed reference for authors on important issues to consider when designing, conducting, and analyzing tumor marker prognostic studies

Reinforced bioactive bone chip scaffold for bone regeneration: experimental study

Purpose: Scaffolds play a critical role in tissue engineering, which aims to regenerate missing tissues or organs. For developing an effective bone regeneration strategy, we studied the efficacy of bone regeneration using the innovative bone scaffold \u201cReinforced Bioactive Bone Chip\u201d (IBI S/A-Mezzovico, Ticino-CH), which has been specifically developed for applications in regenerative medicine and therapy bone tissue engineering, on the calvarial defect of rats. Methods and materials: A full-thickness defect (5mm 78mm) was created on each parietal region of Wistar rats (Harlan, Italy) by piezosurgery, a surgical technique that creates an effective osteotomy with no trauma to soft tissue and without causing bone necrosis. Bone scaffold was implanted in the right cranial defect whereas the left defect was used as control. Macroscopical evaluation of the surgical site and histological studies were performed to investigate the level of bone formation. Results: The results confirmed that the treated defects with \u201cReinforced Bioactive Bone Chip\u201d scaffold showed significant bone formation and maturation in comparison with the control group. Conclusion: These results are promising and \u201cReinforced Bioactive Bone Chip\u201d could be considered for future clinical use in human, mainly in the field of regeneration and/or replacement of bone tissue compartment of maxillofacial surgery

Síndrome do desfiladeiro torácico - ressecção de costela cervical por videotoracoscopia Thoracic outlet syndrome - cervical rib resection through videothoracoscopic surgery

A base do tratamento cirúrgico da Síndrome do Desfiladeiro Torácico (SDT) é a ressecção da primeira costela, podendo associar-se à escalenectomia ou ainda à ressecção de costela cervical. Esta última é feita tradicionalmente por meio de um acesso supraclavicular ou mesmo axilar, o qual é tecnicamente mais trabalhoso. Pode ser realizada também por meio de acesso paraescapular. Embora tecnicamente atrativa e associada à menor invasividade e maior segurança, com ótimo resultado estético, a ressecção da primeira costela torácica, por intermédio de cirurgia videoassistida transaxilar ou pela técnica videotoracoscópica, é pouco relatada na literatura, e nenhuma referência foi encontrada sobre ressecção de costela cervical mediante essa técnica. Neste artigo, apresentamos essa inovação cirúrgica realizada com sucesso para ressecção de costela cervical em duas pacientes.<br>The basis of Thoracic Outlet Syndrome (TOS) surgical treatment is the first rib resection and may be associated with scalenectomy or cervical rib resection. The latter is traditionally done through a supraclavicular or axillary access, which is the most technically challenging. It can also be achieved through parascapular access. Although technically attractive and associated with less invasiveness and increased security, with excellent aesthetic results, the first thoracic rib resection via video-assisted transaxillary surgery or videothoracoscopic technique is seldom reported in the literature, and no reference was found on cervical rib resection through this technique. In this article, we introduced this innovation successfully performed for surgical cervical rib resection in two patients