Patients’, Caregivers’, and Providers’ Perceived Strategies for Diabetes Care

Objectives: To explore strategies to improve type 2 diabetes mellitus (T2DM) self-management among low-income and minority groups. Methods: Focus groups centered on T2DM self-care behaviors were conducted using convenient sample of patients with T2DM (N = 17), caregivers (N = 5) and healthcare providers (N = 15). Results: Patients and caregivers perceived strategies included improving patient-provider communication, providers’ accessibility and compassion, and flexible clinic hours. Strategies identified by providers were realistic patient’s expectations, family support, and community resources. Conclusions: To our knowledge, this study is the first to elicit strategies to improve T2DM self-management through a joint meeting of patients, caregivers, and healthcare providers. Study findings could help inform future efforts to assist patients better manage their T2DM

Ausência de efeito antinociceptivo decorrente da administração intravenosa de crotalfina em comparação com morfina, U50-488H ou fenilbutazona em equinos submetidos à estimulação térmica da pele íntegra

Crotalfina é um novo peptídeo analgésico que atua em receptores opioides kappa e delta promovendo potente analgesia em ratos submetidos a modelos de dor inflamatória, neuropática ou oncológica. Talvez a crotalfina possa ser utilizada para tratar a dor em outras espécies. Assim, o objetivo deste estudo foi avaliar a resposta nociceptiva na região escapular e isquiática de cavalos tratados com crotalfina, morfina, U50-488H ou fenilbutazona e submetidos à estimulação térmica na pele íntegra. Dezoito cavalos da raça Puro Sangue Árabe foram alocados em cinco grupos experimentais: GC (5mL NaCl 0,9%), GCRO (3,8mg.kg-1 crotalfina), GK (160 µg.kg-1 U50-488H), GM (0,1mg.kg-1 morfina) e GF (4,4mg.kg-1 fenilbutazona). Os animais foram submetidos ao modelo de dor inflamatória por meio de estimulação térmica (140°C) e durante 24h avaliou-se a latência para o reflexo do frêmito cutâneo na região escapular (LRFCesc) e isquiática (LRFCisq). O U50-488H apresentou efeito antinociceptivo na região isquiática por duas horas, porém, nos demais momentos do grupo GK, bem como nos grupos GC, GCRO, GM e GF, não foi observado efeito antinociceptivo, visto que a LRFCesc e a LRFCisq na pele íntegra de cavalos não aumentaram em 24 horas de avaliação. Portanto, a crotalfina, a morfina, o U50-488H e a fenilbutazona não produziram efeito antinociceptivo relevante em equinos submetidos à estimulação térmica em pele íntegra.Crotalphine is a novel analgesic peptide that acts on kappa and delta opioid receptors providing powerful analgesia in rats submitted to inflammatory, neuropathic or oncologic pain model. Maybe crotalphine can be used to treat pain in other species. So, the aim of this study was to evaluate nociceptive response at scapular and isquiatic region of horses treated with crotalphine, morphine, U50-488H or phenylbutazone and submitted to thermal stimulation in complete skin. Eighteen Arabian horses were allocated in five experimental groups: GC (5mL NaCl 0.9%), GCRO (3.8ng.kg-1 crotalphine), GK (160 µg.kg-1 U50-488H), GM (0.1mg.kg-1 morphine) and GP (4.4mg.kg-1 phenylbutazone). Animals were submitted to inflammatory pain model by thermal stimulation (140°C) and during 24h latency to skin twitch at scapular and isquiatic region were evaluated. The U50-488H produced antinociceptive effect at isquiatic region along two hours, but, in other moments of GK and in the other groups there was not antinociceptive effect, because LRFCesc and LRFCisq in complete skin of horses did not increase during 24h evaluation. Thus, crotalphine, morphine, U50-488H and phenylbutazone did not cause relevant antinociceptive effect in horses submitted to thermal stimulation in complete skin.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal do Paraná (UFPR) Curso de Medicina VeterináriaUniversidade Federal do Recôncavo Baiano (UFRB) Curso de Medicina VeterináriaConsórcio da Indústria Farmacêutica (COINFAR)Instituto Butantan Laboratório de PatofisiologiaUniversidade Estadual Paulista (UNESP) Departamento de Clínica e Cirurgia VeterináriaUniversidade Estadual Paulista (UNESP) Departamento de Clínica e Cirurgia Veterinári

Study of the embryotoxic effects of an extract of rosemary (Rosmarinus officinalis L)

Extracts of rosemary, Rosmarinus officinalis L., have been used in folk medicine as a diuretic, an emenagogue, an antispasmodic and its aqueous extract does not present toxicity to man, presenting, however, abortive effects. In order to evaluate if this plant induces abortion and/or interferes with the normal development of the concepts, doses of 26 mg of a 30% (w/v) R. officinalis aqueous extract (13 mg solids/ml) made with leaves, flowers and stem were administered daily by gavage during two different periods of Wistar rat pregnancy. One group of animals (N = 12) received the extract from days 1 to 6 of pregnancy (preimplantation period) and another group (N = 14) received the same extract from days 6 to 15 of pregnancy (organogenic period). Control groups (N = 12) received saline in the same volume and during the same periods as their respective experimental groups. The animals were sacrificed at term. The treatment of the darns during either the preimplantation or the organogenic period did not cause significant changes in the postimplantation loss or in the number of anomalies or malformations of the term fetuses, which also showed a similar degree of development when compared with the respective controls. The percent of preimplantation loss in the group treated before embryo implantation increased, although the difference was not significant compared to the control. This result suggests that rosemary extract may present an anti-implantation effect without interfering with the normal development of the concept after implantation.UNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT FARMACOL,LAB TERATOL EXPTL,BR-18618000 BOTUCATU,SP,BRAZILUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT FARMACOL,LAB TERATOL EXPTL,BR-18618000 BOTUCATU,SP,BRAZI

Study of the embryotoxic effects of an extract of rosemary (Rosmarinus officinalis L)

Extracts of rosemary, Rosmarinus officinalis L., have been used in folk medicine as a diuretic, an emenagogue, an antispasmodic and its aqueous extract does not present toxicity to man, presenting, however, abortive effects. In order to evaluate if this plant induces abortion and/or interferes with the normal development of the concepts, doses of 26 mg of a 30% (w/v) R. officinalis aqueous extract (13 mg solids/ml) made with leaves, flowers and stem were administered daily by gavage during two different periods of Wistar rat pregnancy. One group of animals (N = 12) received the extract from days 1 to 6 of pregnancy (preimplantation period) and another group (N = 14) received the same extract from days 6 to 15 of pregnancy (organogenic period). Control groups (N = 12) received saline in the same volume and during the same periods as their respective experimental groups. The animals were sacrificed at term. The treatment of the darns during either the preimplantation or the organogenic period did not cause significant changes in the postimplantation loss or in the number of anomalies or malformations of the term fetuses, which also showed a similar degree of development when compared with the respective controls. The percent of preimplantation loss in the group treated before embryo implantation increased, although the difference was not significant compared to the control. This result suggests that rosemary extract may present an anti-implantation effect without interfering with the normal development of the concept after implantation

Effects of intermittent and continuous positive pressure ventilation on renal hemodynamics

Concurso Docencia-Livre, Dept. Anestesiol., Fac. Med., Campus de Botucatu - UNESP, Sao Paul