Human stem cell neuronal differentiation on silk-carbon nanotube composite

Human embryonic stem cells [hESCs] are able to differentiate into specific lineages corresponding to regulated spatial and temporal signals. This unique attribute holds great promise for regenerative medicine and cell-based therapy for many human diseases such as spinal cord injury [SCI] and multiple sclerosis [MS]. Carbon nanotubes [CNTs] have been successfully used to promote neuronal differentiation, and silk has been widely applied in tissue engineering. This study aims to build silk-CNT composite scaffolds for improved neuron differentiation efficiency from hESCs

Revisiting Kalundu Mound, Zambia: implications for the timing of social and subsistence transitions in Iron Age Southern Africa

Novel trajectories of food production, urbanism, and inter-regional trade fueled the emergence of numerous complex Iron Age polities in central and southern Africa. Renewed research and re-dating efforts in Botswana, Zimbabwe, and along the Swahili Coast are transforming models for how inter-regional interaction spheres contributed to these patterns. While societies in present-day Zambia played an important role in the trade of copper, ivory, gold, and other resources between central and southern Africa, little is known about lifeways during the rise of social complexity in this region. This paper reports the results of re-excavation at Kalundu Mound on the Batoka Plateau of southern Zambia, one of the iconic mound sites of the Iron Age “Kalomo Culture.” New radiocarbon dates were combined with the original dates in a series of Bayesian models, indicating that previous chronologies for the site are not reliable and that the mound site likely developed rapidly from AD 1190 to 1410. Archaeobotanical, zooarchaeological, and paleo-proteomic analyses of excavated materials suggests a broad subsistence base combining wild and domesticated species, including the first reported evidence for finger millet (Eleusine coracana) in the region. Considering these findings, it is necessary to re-evaluate the temporal context of the Kalomo site-group, and to also systematically reinvestigate the systems of exchange and subsistence that supported Later Iron Age complexity.Introduction Situating Kalundu Mound Within the Regional Archaeology Kalundu Mound and the Kalomo Culture - Environmental Setting and Regional History - The 1957 Excavations - The 1960–1962 Excavations - The 2017 Excavations Results - Stratigraphy - Chronology - Chronological Modeling Results - Chronology Summary Subsistence - Faunal Remains - Macrobotanical Remains - Material culture Discussion - Site Formation - Iron Age Agriculture at Kalundu - Chronology for Kalundu Mound and the Kalomo Group Conclusio

Revisiting Kalundu Mound, Zambia: Implications for the Timing of Social and Subsistence Transitions in Iron Age Southern Africa

Novel trajectories of food production, urbanism, and inter-regional trade fueled the emergence of numerous complex Iron Age polities in central and southern Africa. Renewed research and re-dating efforts in Botswana, Zimbabwe, and along the Swahili Coast are transforming models for how inter-regional interaction spheres contributed to these patterns. While societies in present-day Zambia played an important role in the trade of copper, ivory, gold, and other resources between central and southern Africa, little is known about lifeways during the rise of social complexity in this region. This paper reports the results of re-excavation at Kalundu Mound on the Batoka Plateau of southern Zambia, one of the iconic mound sites of the Iron Age “Kalomo Culture.” New radiocarbon dates were combined with the original dates in a series of Bayesian models, indicating that previous chronologies for the site are not reliable and that the mound site likely developed rapidly from AD 1190 to 1410. Archaeobotanical, zooarchaeological, and paleo-proteomic analyses of excavated materials suggests a broad subsistence base combining wild and domesticated species, including the first reported evidence for finger millet (Eleusine coracana) in the region. Considering these findings, it is necessary to re-evaluate the temporal context of the Kalomo site-group, and to also systematically reinvestigate the systems of exchange and subsistence that supported Later Iron Age complexity

Highly multimode memory in a crystal

We experimentally demonstrate the storage of 1060 temporal modes onto a thulium-doped crystal using an atomic frequency comb (AFC). The comb covers 0.93 GHz defining the storage bandwidth. As compared to previous AFC preparation methods (pulse sequences i.e. amplitude modulation), we only use frequency modulation to produce the desired optical pumping spectrum. To ensure an accurate spectrally selective optical pumping, the frequency modulated laser is self-locked on the atomic comb. Our approach is general and should be applicable to a wide range of rare-earth doped material in the context of multimode quantum memory

Chylous ascites following robotic lymph node dissection on a patient with metastatic cervical carcinoma

Chylous ascites is an uncommon postoperative complication of gynecological surgery. We report a case of chylous ascites following a robotic lymph node dissection for a cervical carcinoma. A 38-year-old woman with IB2 cervical adenocarcinoma with a palpable 3 cm left external iliac lymph node was taken to the operating room for robotic-assisted laparoscopic pelvic and para-aortic lymph node dissection. Patient was discharged on postoperative day 2 after an apparent uncomplicated procedure. The patient was readmitted the hospital on postoperative day 9 with abdominal distention and a CT-scan revealed free fluid in the abdomen and pelvis. A paracentesis demonstrated milky-fluid with an elevated concentration of triglycerides, confirming the diagnosis of chylous ascites. She recovered well with conservative measures. The risk of postoperative chylous ascites following lymph node dissection is still present despite the utilization of new technologies such as the da Vinci robot

Hybrid electron spin resonance and whispering gallery mode resonance spectroscopy of Fe3+ in sapphire

The development of a new era of quantum devices requires an understanding of how paramagnetic dopants or impurity spins behave in crystal hosts. Here, we describe a spectroscopic technique which uses traditional electron spin resonance (ESR) combined with the measurement of a large population of electromagnetic whispering gallery modes. This allows the characterization of the physical parameters of paramagnetic impurity ions in the crystal at low temperatures. We present measurements of two ultrahigh-purity sapphires cooled to 20 mK in temperature, and determine the concentration of Fe3 ions and their frequency sensitivity to a dc magnetic field. Our method is different from ESR in that it is possible to track the resonant frequency of the ion from zero applied magnetic field to any arbitrary value, allowing excellent measurement precision. This high precision reveals anisotropic behavior of the Zeeman splitting. In both crystals, each Zeeman component demonstrates a different g factor

Interactions between metabolic, reward and cognitive processes in appetite control:Implications for novel weight management therapies

Traditional models of appetite control have emphasised the role of parallel homeostatic and hedonic systems, but more recently the distinction between independent homeostatic and hedonic systems has been abandoned in favour of a framework that emphasises the cross talk between the neurochemical substrates of the two systems. In addition, evidence has emerged more recently, that higher level cognitive functions such as learning, memory and attention play an important role in everyday appetite control and that homeostatic signals also play a role in cognition. Here, we review this evidence and present a comprehensive model of the control of appetite that integrates cognitive, homeostatic and reward mechanisms. We discuss the implications of this model for understanding the factors that may contribute to disordered patterns of eating and suggest opportunities for developing more effective treatment approaches for eating disorders and weight management