An ecological study of trends in cancer incidence and dietary changes in Hong Kong

Cancer incidence rates from the Hong Kong Cancer Registry show significant increases in lung and colon cancers and decreases in nasopharyngeal cancer in both sexes from 1973 to 1992. Moreover, cervical cancer and male esophageal cancer have declined significantly, and changes in the trends of cancer of the following sites were of borderline significance: decreasing male laryngeal and female esophageal cancers and increasing prostate and female breast cancers. These changes have occurred along with dietary shifts in the population, from a diet predominantly of rice and small portions of meat, vegetables, and fish to one with larger portions of all foods but rice and eggs. The latter data were gathered from six government household surveys from 1963-64 to 1994-95. By combining the two data sets, correlation coefficients were calculated for per capita consumption patterns of eight foods (rice, pork, beef, poultry, saltwater fish, freshwater fish, fresh vegetables, and eggs) and cancer incidence data of the same year or 10 years later. Higher meat intakes were significantly and positively correlated with cancers of the colon, rectum, prostate, and female breast. The correlations also suggested that current diets were more influential than diets a decade before for cancers of the lung, esophagus, rectum, and prostate. Cancers of the nasopharynx and colon were significantly correlated with current and past diets. These results support the hypothesis that intakes of meat and its associated fat are risk factors for colon, rectal, prostate, and female breast cancers.published_or_final_versio

A radio census of nuclear activity in nearby galaxies

In order to determine the incidence of black hole accretion-driven nuclear activity in nearby galaxies, as manifested by their radio emission, we have carried out a high-resolution Multi-Element Radio-Linked Interferometer Network (MERLIN) survey of LINERs and composite LINER/HII galaxies from a complete magnitude-limited sample of bright nearby galaxies (Palomar sample) with unknown arcsecond-scale radio properties. There are fifteen radio detections, of which three are new subarcsecond-scale radio core detections, all being candidate AGN. The detected galaxies supplement the already known low-luminosity AGN - low-luminosity Seyferts, LINERs and composite LINER/HII galaxies - in the Palomar sample. Combining all radio-detected Seyferts, LINERs and composite LINER/HII galaxies (LTS sources), we obtain an overall radio detection rate of 54% (22% of all bright nearby galaxies) and we estimate that at least similar to 50% (similar to 20% of all bright nearby galaxies) are true AGN. The radio powers of the LTS galaxies allow the construction of a local radio luminosity function. By comparing the luminosity function with those of selected moderate-redshift AGN, selected from the 2dF/NVSS survey, we find that LTS sources naturally extend the RLF of powerful AGN down to powers of about 10 times that of Sgr A*.</p

Examining Distinctive Working Memory Profiles in Chinese Children With Predominantly Inattentive Subtype of Attention-Deficit/Hyperactivity Disorder and/or Reading Difficulties

Although evidence has shown that both RD and ADHD-I children suffer from working memory problems, inconsistencies in impaired modalities have been reported. This study aimed to (1) compare the three WM domains (i.e., verbal WM, visual-spatial WM, and behavioral WM) among pure ADHD-I, pure RD, comorbid ADHD-I+RD, and typical control groups and (2) examine the impact of comorbidity on the three WM domains. A Chinese sample of participants from Hong Kong included 29 children in the ADHD-I group, 78 children in the RD group, 31 children in the comorbid group (ADHD-I+RD), and 64 children in the TD control group. All participants completed the assessments individually. The findings showed that the children with ADHD-I and/or RD exhibited diverse cognitive profiles. In particular, RD was associated with verbal and visual-spatial working memory deficits, while ADHD-I was associated with behavioral working memory deficits. Interestingly, the comorbid condition demonstrated additive deficits of the two disorders but with greater deficits in behavioral working memory. These findings support the cognitive subtype hypothesis and provide a clearer picture of the distinctive working memory profiles of different groups, allowing for the development of intervention programs in the future

Chemical composition of Hyptis suaveolens and Ocimum gratissimum hybrids from Nigeria

Four medicinal plants belonging to the family Lamiaceae were chemically screened for their chemical constituents including alkaloids, tannins, saponins, flavonoids and phenols. The medicinal plants investigated were Hyptis suaveloens and three putative hybrids of Ocimum gratissimum (Hybrid A, B and C). All the plants contains high percentage yield of crude alkaloids and flavonoids ranging from 10.44 to 14.32% and 9.28 to 12.54%, respectively. Only H. suaveloens is devoid of saponins. Tanninsand phenols were present in all plants. The nutritional values of the phytochemicals were also assessed with a view of establishing and understanding their nutritional uses. The plants contained crude protein(9.19 to 17.94%), crude fibre (4.88 to 9.04%), ash (5.68 to 6.88%), carbohydrate (66.24 to 75.87%), crude lipid (3.48 to 4.90%) and food energy (357.68 to 373.26 mg/cal). The significance of the plants in traditional medicine and the importance of the chemical constituents in the pharmaceutical industries were discusse

Supermassive black holes do not correlate with dark matter halos of galaxies

Supermassive black holes have been detected in all galaxies that contain bulge components when the galaxies observed were close enough so that the searches were feasible. Together with the observation that bigger black holes live in bigger bulges, this has led to the belief that black hole growth and bulge formation regulate each other. That is, black holes and bulges "coevolve". Therefore, reports of a similar correlation between black holes and the dark matter halos in which visible galaxies are embedded have profound implications. Dark matter is likely to be nonbaryonic, so these reports suggest that unknown, exotic physics controls black hole growth. Here we show - based in part on recent measurements of bulgeless galaxies - that there is almost no correlation between dark matter and parameters that measure black holes unless the galaxy also contains a bulge. We conclude that black holes do not correlate directly with dark matter. They do not correlate with galaxy disks, either. Therefore black holes coevolve only with bulges. This simplifies the puzzle of their coevolution by focusing attention on purely baryonic processes in the galaxy mergers that make bulges.Comment: 12 pages, 9 Postscript figures, 1 table; published in Nature (20 January 2011

Common correlates of suicidal ideation and physical assault among male and female university students in Hong Kong

This study examined prevalence and correlates of suicidal ideation and dating partner violence in a cohort of 651 university students in social sciences classes at three universities in Hong Kong. A standard questionnaire was completed within one class period to examine the rates of occurrence of physical assault perpetration and suicidal ideation. Separate rates are presented for male and female perpetrators and for severe and overall levels of violence. The differences between subjects having suicidal ideation are compared using t tests. Logistic regression is used to predict the presence or absence of physical assault in the preceding year of reporting and suicidal ideation based on the variables such as Personal Relationship Profile, age, relationship length, and socioeconomic status. Results showed that 55% of suicidal persons had a history of violence, whereas 39% of violent people had a history of suicidal ideation. Logistic regression showed that physical assault shared a total of seven associated factors with suicidal ideation. Suicidal ideation seems to have no direct relation to physical and sexual assault, but they do share some common associated factors that are essential for the development of suicide prevention. © 2007 Springer Publishing Company.postprin

Cost-effectiveness of influenza vaccination for elderly people living in the community.

Key Messages 1. Influenza vaccination of elderly people living in the community was cost-effective from a societal perspective but did not cut publicly funded medical costs or total medical costs. 2. For the oldest group (≥75 years) living in the community, influenza vaccination can cut publicly funded medical costs if the total vaccination cost per head is HK$39.6 or less. 3. Influenza vaccination is costeffective if the value of increasing an elderly person’s lifespan for a year at most is measured as HK$68 047 or more.published_or_final_versio

Structural and Functional Brain Remodeling during Pregnancy with Diffusion Tensor MRI and Resting-State Functional MRI

Although pregnancy-induced hormonal changes have been shown to alter the brain at the neuronal level, the exact effects of pregnancy on brain at the tissue level remain unclear. In this study, diffusion tensor imaging (DTI) and resting-state functional MRI (rsfMRI) were employed to investigate and document the effects of pregnancy on the structure and function of the brain tissues. Fifteen Sprague-Dawley female rats were longitudinally studied at three days before mating (baseline) and seventeen days after mating (G17). G17 is equivalent to the early stage of the third trimester in humans. Seven age-matched nulliparous female rats served as non-pregnant controls and were scanned at the same time-points. For DTI, diffusivity was found to generally increase in the whole brain during pregnancy, indicating structural changes at microscopic levels that facilitated water molecular movement. Regionally, mean diffusivity increased more pronouncedly in the dorsal hippocampus while fractional anisotropy in the dorsal dentate gyrus increased significantly during pregnancy. For rsfMRI, bilateral functional connectivity in the hippocampus increased significantly during pregnancy. Moreover, fractional anisotropy increase in the dentate gyrus appeared to correlate with the bilateral functional connectivity increase in the hippocampus. These findings revealed tissue structural modifications in the whole brain during pregnancy, and that the hippocampus was structurally and functionally remodeled in a more marked manner.published_or_final_versio