Computational Homogenization of Architectured Materials

Architectured materials involve geometrically engineered distributions of microstructural phases at a scale comparable to the scale of the component, thus calling for new models in order to determine the effective properties of materials. The present chapter aims at providing such models, in the case of mechanical properties. As a matter of fact, one engineering challenge is to predict the effective properties of such materials; computational homogenization using finite element analysis is a powerful tool to do so. Homogenized behavior of architectured materials can thus be used in large structural computations, hence enabling the dissemination of architectured materials in the industry. Furthermore, computational homogenization is the basis for computational topology optimization which will give rise to the next generation of architectured materials. This chapter covers the computational homogenization of periodic architectured materials in elasticity and plasticity, as well as the homogenization and representativity of random architectured materials

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

Aberrant Hedgehog/GLI signaling has been implicated in a diverse spectrum of human cancers, but its role in lung adenocarcinoma (LAC) is still under debate. We show that the downstream effector of the Hedgehog pathway, GLI1, is expressed in 76% of LACs, but in roughly half of these tumors, the canonical pathway activator, Smoothened, is expressed at low levels, possibly owing to epigenetic silencing. In LAC cells including the cancer stem cell compartment, we show that GLI1 is activated noncanonically by MAPK/ERK signaling. Different mechanisms can trigger the MAPK/ERK/GLI1 cascade including KRAS mutation and stimulation of NRP2 by VEGF produced by the cancer cells themselves in an autocrine loop or by stromal cells as paracrine cross talk. Suppression of GLI1, by silencing or drug-mediated, inhibits LAC cells proliferation, attenuates their stemness and increases their susceptibility to apoptosis in vitro and in vivo. These findings provide insight into the growth of LACs and point to GLI1 as a downstream effector for oncogenic pathways. Thus, strategies involving direct inhibition of GLI1 may be useful in the treatment of LACs

The 4π neutron detector CARMEN

International audienceCARMEN is a 4π neutron detector filled with a gadolinium-loaded liquid scintillator built to measure neutron multiplicity distributions. It is used to study fission and (n,xn) reactions. In addition to neutron multiplicity measurements, CARMEN can be used to measure neutron energy spectra with the time-of-flight technique, thanks to the time properties of the prompt signal. The detector, detection technique and efficiency determination are presented in detail. Two examples are also presented: the measurement of 252Cf spontaneous fission neutron multiplicity probability distribution and the measurement of the neutron energy spectrum emitted by an Am-Be radioactive source

Inefficient magnetic-field amplification in supersonic laser-plasma turbulence

We report a laser-plasma experiment that was carried out at the LMJ-PETAL facility and realized the first magnetized, turbulent, supersonic plasma with a large magnetic Reynolds number ($\mathrm{Rm} \approx 45$) in the laboratory. Initial seed magnetic fields were amplified, but only moderately so, and did not become dynamically significant. A notable absence of magnetic energy at scales smaller than the outer scale of the turbulent cascade was also observed. Our results support the notion that moderately supersonic, low-magnetic-Prandtl-number plasma turbulence is inefficient at amplifying magnetic fields

Enhanced ion acceleration using the high-energy petawatt PETAL laser

The high-energy petawatt PETAL laser system was commissioned at CEA’s Laser Mégajoule facility during the 2017–2018 period. This paper reports in detail on the first experimental results obtained at PETAL on energetic particle and photon generation from solid foil targets, with special emphasis on proton acceleration. Despite a moderately relativistic (<1019 W/cm2) laser intensity, proton energies as high as 51 MeV have been measured significantly above those expected from preliminary numerical simulations using idealized interaction conditions. Multidimensional hydrodynamic and kinetic simulations, taking into account the actual laser parameters, show the importance of the energetic electron production in the extended low-density preplasma created by the laser pedestal. This hot-electron generation occurs through two main pathways: (i) stimulated backscattering of the incoming laser light, triggering stochastic electron heating in the resulting counterpropagating laser beams; (ii) laser filamentation, leading to local intensifications of the laser field and plasma channeling, both of which tend to boost the electron acceleration. Moreover, owing to the large (∼100 μm) waist and picosecond duration of the PETAL beam, the hot electrons can sustain a high electrostatic field at the target rear side for an extended period, thus enabling efficient target normal sheath acceleration of the rear-side protons. The particle distributions predicted by our numerical simulations are consistent with the measurements

LBA58_PR Second or 3rd line nivolumab (Nivo) versus nivo plus ipilimumab (Ipi) in malignant pleural mesothelioma (MPM) patients: Updated results of the IFCT-1501 MAPS2 randomized phase 2 trial.

International audienc

Physics of chromatic focusing, post-acceleration and bunching of laser-driven proton beams in helical coil targets

To increase the fluence and maximum energy of laser-driven proton beams in view of potential applications such as isochoric heating of dense material or isotope production, it has been proposed to attach a helical coil normally to the rear side of the irradiated target. By driving the target discharge current pulse through the coil, this scheme allows a fraction of the proton beam to be selected in energy and to be focused and further accelerated. The previously published results are extended to higher laser pulse energies and longer coils. This leads to an increased number of guided protons and the generation of several proton bunches. Large scale particle-in-cell simulations with realistic boundary conditions reproduce well the experimental results. A detailed analysis of the numerical simulations and an analytical model demonstrate that the current propagation along a helical wire differs from the one of a linear or folded wire. In a helical wire, the current pulse is subject to velocity dispersion, which results in progressive modification of its spatial profile, and so in proton bunch trapping and focusing