661 research outputs found
A Physical Limit to the Magnetic Fields of T Tauri Stars
Recent estimates of magnetic field strengths in T Tauri stars yield values
--. In this paper, I present an upper limit to the
photospheric values of by computing the equipartition values for different
surface gravities and effective temperatures. The values of derived from
the observations exceed this limit, and I examine the possible causes for this
discrepancy
Milne-Eddington inversion of the Fe I line pair at 630~nm
The iron lines at 630.15 and 630.25 nm are often used to determine the
physical conditions of the solar photosphere. A common approach is to invert
them simultaneously under the Milne-Eddington approximation. The same
thermodynamic parameters are employed for the two lines, except for their
opacities, which are assumed to have a constant ratio. We aim at investigating
the validity of this assumption, since the two lines are not exactly the same.
We use magnetohydrodynamic simulations of the quiet Sun to examine the behavior
of the ME thermodynamic parameters and their influence on the retrieval of
vector magnetic fields and flow velocities. Our analysis shows that the two
lines can be coupled and inverted simultaneously using the same thermodynamic
parameters and a constant opacity ratio. The inversion of two lines is
significantly more accurate than single-line inversions because of the larger
number of observables.Comment: Accepted for publication in Astronomy and Astrophysics (Research
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Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
The activation of human platelets by α-thrombin is mediated at least in part by cleavage of protease-activated G-protein-coupled receptors, PAR-1 and PAR-4. Platelet glycoprotein Ibα also has a high affinity binding site for α-thrombin, and this interaction contributes to platelet activation through a still unknown mechanism. In the present study the hypothesis that GpIbα may contribute to platelet activation by modulating the hydrolysis of PAR-1 on the platelet membrane was investigated. Gel-filtered platelets from normal individuals were stimulated by α-thrombin, and the kinetics of PAR-1 hydrolysis by enzyme was followed with flow cytometry using an anti-PAR-1 monoclonal antibody (SPAN 12) that recognizes only intact PAR-1 molecules. This strategy allowed measurement of the apparentk cat/K m value for thrombin hydrolysis of PAR-1 on intact platelets, which was equal to 1.5 ± 0.1 × 107 m −1sec−1. The hydrolysis rate of PAR-1 by thrombin was measured under conditions in which thrombin binding to GpIb was inhibited by different strategies, with the following results. 1) Elimination of GpIbα on platelet membranes by mocarhagin treatment reduced the k cat/K m value by about 6-fold. 2) A monoclonal anti-GpIb antibody reduced the apparent k cat/K m value by about 5-fold. 3) An oligonucleotide DNA aptamer, HD22, which binds to the thrombin heparin-binding site (HBS) and inhibits thrombin interaction with GpIbα, reduced the apparentk cat/K m value by about 5-fold. 4) Displacement of α-thrombin from the binding site on GpIb using PPACK-thrombin reduced the apparentk cat/K m value by about 5-fold, and 5) mutation at the HBS of thrombin (R98A) caused a 5-fold reduction of the apparentk cat/K m value of PAR-1 hydrolysis. Altogether these results show that thrombin interaction with GpIb enhances the specificity of thrombin cleavage of PAR-1 on intact platelets, suggesting that GpIb may function as a “cofactor” for PAR-1 activation by thrombin
The Immune Response to Tumors as a Tool toward Immunotherapy
Until recently cancer medical therapy was limited to chemotherapy that could not differentiate cancer cells from normal cells. More recently with the remarkable mushroom of immunology, newer tools became available, resulting in the novel possibility to attack cancer with the specificity of the immune system. Herein we will review some of the recent achievement of immunotherapy in such aggressive cancers as melanoma, prostatic cancer, colorectal carcinoma, and hematologic malignancies.
Immunotherapy of tumors has developed several techniques: immune cell transfer, vaccines, immunobiological molecules such as monoclonal antibodies that improve the immune responses to tumors. This can be achieved by blocking pathways limiting the immune response, such as CTLA-4 or Tregs. Immunotherapy may also use cytokines especially proinflammatory cytokines to enhance the activity of cytotoxic T cells (CTLs) derived from tumor infiltrating lymphocytes (TILs). The role of newly discovered cytokines remains to be investigated. Alternatively, an other mechanism consists in enhancing the expression of TAAs on tumor cells. Finally, monoclonal antibodies may be used to target oncogenes
Time-Dependent Behavior of Linear Polarization in Unresolved Photospheres, With Applications for The Hanle Effect
Aims: This paper extends previous studies in modeling time varying linear
polarization due to axisymmetric magnetic fields in rotating stars. We use the
Hanle effect to predict variations in net line polarization, and use geometric
arguments to generalize these results to linear polarization due to other
mechanisms. Methods: Building on the work of Lopez Ariste et al., we use simple
analytic models of rotating stars that are symmetric except for an axisymmetric
magnetic field to predict the polarization lightcurve due to the Hanle effect.
We highlight the effects for the variable line polarization as a function of
viewing inclination and field axis obliquity. Finally, we use geometric
arguments to generalize our results to linear polarization from the weak
transverse Zeeman effect. Results: We derive analytic expressions to
demonstrate that the variable polarization lightcurve for an oblique magnetic
rotator is symmetric. This holds for any axisymmetric field distribution and
arbitrary viewing inclination to the rotation axis. Conclusions: For the
situation under consideration, the amplitude of the polarization variation is
set by the Hanle effect, but the shape of the variation in polarization with
phase depends largely on geometrical projection effects. Our work generalizes
the applicability of results described in Lopez Ariste et al., inasmuch as the
assumptions of a spherical star and an axisymmetric field are true, and
provides a strategy for separating the effects of perspective from the Hanle
effect itself for interpreting polarimetric lightcurves.Comment: 6 pages; 4 figures. Includes an extra figure found only in this
preprint versio
Analytical maximum likelihood estimation of stellar magnetic fields
The polarised spectrum of stellar radiation encodes valuable information on
the conditions of stellar atmospheres and the magnetic fields that permeate
them. In this paper, we give explicit expressions to estimate the magnetic
field vector and its associated error from the observed Stokes parameters. We
study the solar case where specific intensities are observed and then the
stellar case, where we receive the polarised flux. In this second case, we
concentrate on the explicit expression for the case of a slow rotator with a
dipolar magnetic field geometry. Moreover, we also give explicit formulae to
retrieve the magnetic field vector from the LSD profiles without assuming mean
values for the LSD artificial spectral line. The formulae have been obtained
assuming that the spectral lines can be described in the weak field regime and
using a maximum likelihood approach. The errors are recovered by means of the
hermitian matrix. The bias of the estimators are analysed in depth.Comment: accepted for publication in MNRA
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