Deploying CORBA Components on a Computational Grid: General Principles and Early Experiments Using the Globus Toolkit

The deployment of high bandwidth wide-area networks has led computational grids to offer a very powerful computing resource. In particular, this inherently distributed resource is well-suited for multiphysics applications. To face the complexity of such applications, the software component technology appears to be a very adequate programming model. However, to take advantage of the computational power of grids, component-based applications should be automatically deployed in computational grids. Based on the CORBA component specifications for the deployment of components, which seem to currently be the most complete, this paper proposes a detailed process for component deployment in computational grids. It also reports on early experiments on deploying CORBA components in a computational grid using the Globus Toolkit 2.4

Magnetic SAW RFID Sensor Based on Love Wave for Detection of Magnetic Field and Temperature

Magnetic field measurement including a temperature compensation is essential for a magnetic field sensor. This study investigates a magnetic surface acoustic wave (MSAW) sensor in a reflective delay line configuration with two acoustic propagation paths with and without magnetic field sensitive layer. The delay in path with sensitive layer leads to magnetic field detection and the one without enable temperature measurement and thus compensation for the first path. The developed sensor is based on a ZnO/LiNbO$_3$ Ycut (X-direction) layered structure as Love wave platform. Love wave as a shear wave being more favorable for magnetic detection. Co-Fe-B is considered as sensitive layer to detect magnetic field changes and is deposited on the top of ZnO, but only on one of the two paths. We combined an original configuration of connected IDTs with a high electromechanical coupling coefficient (K$^2$) mode to improve the signal amplitude. The achieved sensor exhibits a high temperature and magnetic field sensitivity of -63 ppm/$^\circ$C and -781 ppm/mT, respectively. The temperature compensation method for magnetic field measurement is demonstrated using a differential measurement by subtracting the delay times obtained for the two paths with and without the sensitive layer. Finally, The sensor exhibited good repeatability at various temperatures. Moreover, the device developed allows in addition to the multisensor functionality, the radio frequency identification (RFID) which is necessary for the deployment of sensor networks

Intrinsic versus shape anisotropy in micro-structured magnetostrictive thin films for magnetic surface acoustic wave sensors

International audienceThis work aims at studying the interaction between surface acoustic waves (SAW) and micro-structured magnetostrictive layers under a magnetic field with a perspective to develop magnetic field sensors. The impact of the competition between the strong intrinsic magnetic anisotropy of the magnetic material and the shape anisotropy of the interdigitated transducer (IDT) fingers introduced by the micro-structuration is investigated. Therefore, the macroscopic and microscopic magnetic properties of the IDT and their influence on the magneto-acoustic response are studied. A SAW resonator with the IDTs made of the magnetostrictive thin film was elaborated and the magnetic surface acoustic wave (MSAW) response under a magnetic field was performed and discussed. Depending on the energy balance, the anisotropy gets modified and a correlation with the MSAW sensitivity to an externally applied magnetic field is made

Bilateral optic neuropathy related to severe anemia in a patient with alcoholic cirrhosis: A case report and review of the literature

Anemia appears frequently in patients with alcoholic liver disease (ALD) but has never been linked to bilateral nonarteritic anterior ischemic optic neuropathy (NAION). A 65-year-old woman with a medical history of alcoholic cirrhosis was admitted for bilateral NAION. On admission, she was found to have a low arterial pressure and severe normocytic anemia (48 g/L). The anemia was related to chronic bleeding due to antral gastritis along with other factors associated with ALD. The applied treatment consisted of urgent transfusion followed by high doses of proton-pump inhibitors, iron and vitamin supplementation, and support in lifestyle measures. Her hemoglobin levels remained stable after 2 years but the patient still suffered from visual loss. This case highlights the link between anemia and bilateral NAION in ALD patients. The optic nerve head is prone to infarction in this context due to the vascularization characteristics of ALD. Hemoglobin levels should be monitored in ALD patients to avoid the severe complication of NAION

Impact of Emergent Cervical Carotid Stenting in Tandem Occlusion Strokes Treated by Thrombectomy: A Review of the TITAN Collaboration

Introduction: Endovascular therapy has been shown to be an effective and safe treatment for tandem occlusion. The endovascular therapeutic strategies for tandem occlusions strokes have not been adequately evaluated and the best approach is still controversial. The TITAN (Thrombectomy in TANdem occlusions) registry was a result of a collaborative effort to identify the best therapeutic approach for acute ischemic stroke due to tandem lesion. In this review, we aim to summarize the main findings of the TITAN study and discuss the challenges of treatment for tandem occlusion in the era of endovascular thrombectomy.Methods: A review of the data from the multicenter international observational and non-randomized TITAN registry was performed. The TITAN registry included acute ischemic stroke patients with tandem lesions (proximal intracranial occlusion and cervical carotid artery occlusion or stenosis>90%) who were treated with thrombectomy with or without carotid artery stenting.Results: Prior intravenous thrombolysis and emergent cervical carotid stenting were associated with higher reperfusion (mTICI 2b-3 and mTICI 3) rates at the end of the intervention. Poor outcome did not occur more frequently after stenting than after conservative treatment of the cervical carotid lesion. Emergent carotid stenting with antithrombotic agents and intracranial thrombectomy yielded higher reperfusion rate and good outcome (90 day mRS 0–2) compared to other strategies (carotid artery stenting and thrombectomy without antithrombotic, angioplasty and thrombectomy, or thrombectomy alone). Pretreatment intravenous thrombolysis was not associated with increased risk of hemorrhagic complications. Likewise, periprocedural unfractionated heparin did not modify the efficacy and safety results. Etiology of carotid artery lesion (atherosclerosis vs. dissection) did not emerge as predictor of outcome or recanalization.Conclusion: Emergent stenting of the cervical carotid lesion with antithrombotic agents in conjunction to thrombectomy appears to be the best treatment strategy for acute ischemic strokes with tandem lesions. These findings will be further investigated in the ongoing randomized controlled TITAN trial

Characterization of the Benchmark Binary Nltt 33370

We report the confirmation of the binary nature of the nearby, very low-mass system NLTT 33370 with adaptive optics imaging and present resolved near-infrared photometry and integrated light optical and near-infrared spectroscopy to characterize the system. VLT-NaCo and LBTI-LMIRCam images show significant orbital motion between 2013 February and 2013 April. Optical spectra reveal weak, gravity sensitive alkali lines and strong lithium 6708 ˚A absorption that indicate the system is younger than field age. VLT-SINFONI near-IR spectra also show weak, gravity sensitive features and spectral morphology that is consistent with other young, very low-mass dwarfs. We combine the constraints from all age diagnostics to estimate a system age of ∼30-200 Myr. The 1.2-4.7 µm spectral energy distribution of the components point toward Teff = 3200 ± 500 K and Teff = 3100 ± 500 K for NLTT 33370 A and B, respectively. The observed spectra, derived temperatures, and estimated age combine to constrain the component spectral types to the range M6-M8. Evolutionary models predict masses of 113 ±8 MJup and 106±7 MJup from the estimated luminosities of the components. KPNO-Phoenix spectra allow us to estimate the systemic radial velocity of the binary. The Galactic kinematics of NLTT 33370AB are broadly consistent with other young stars in the Solar neighborhood. However, definitive membership in a young, kinematic group cannot be assigned at this time and further follow-up observations are necessary to fully constrain the system’s kinematics. The proximity, age, and late-spectral type of this binary make it very novel and an ideal target for rapid, complete orbit determination. The system is one of only a few model calibration benchmarks at young ages and very low-masses.Astronom

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were detected at very low levels in affected tissues but were undetectable in the blood, indicating that these conditions are postzygotic mosaic disorders. In vitro expression of mutant GNA11(R183C) and GNA11(Q209L) in human cell lines demonstrated activation of the downstream p38 MAPK signaling pathway and the p38, JNK, and ERK pathways, respectively. Transgenic mosaic zebrafish models expressing mutant GNA11(R183C) under promoter mitfa developed extensive dermal melanocytosis recapitulating the human phenotype. Phakomatosis pigmentovascularis and extensive dermal melanocytosis are therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albright and Sturge-Weber syndromes. These findings will allow accurate clinical and molecular diagnosis of this subset of common birthmarks, thereby identifying infants at risk for serious complications, and provide novel therapeutic opportunities

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Contribution à l'automatisation du déploiement d'applications sur des grilles de calcul

Le déploiement d'applications de calcul scientifique sur des grilles informatiques est un problème difficile, du fait de la complexité des applications et de l'hétérogénéité des grilles. Dans le but de masquer ces difficultés, cette thèse propose une architecture qui automatise le processus de déploiement d'applications comprenant plusieurs programmes qui communiquent entre eux sur des grilles de calcul. Nous proposons également un modèle de description de la topologie réseau complexe des grilles, ainsi que des modèles de description spécifique d'applications parallèles et d'applications mixtes (à la fois parallèles et distribuées). Nous introduisons la notion de description générique d'applications, qui permet à un unique planificateur de déploiement de sélectionner les ressources d'exécution et de placer les constituants des applications. Ces contributions sont validées par la mise en oeuvre d'un outil de déploiement automatique.RENNES1-BU Sciences Philo (352382102) / SudocRENNES-INRIA Rennes Irisa (352382340) / SudocSudocFranceF

Les thromboses veineuses cérébrales (étiologies, facteurs de risque, stratégie diagnostique, pronostic et évolution vers les fistules artério-veineuses durales)

NANCY1-SCD Medecine (545472101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF